Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysis
Introduction: Although, some evidence has shown that obestatin, ghrelin, and neurotrophic factors can be involved in the development of cardio-metabolic risk factors, there are some contradictions in this regard. We aimed to investigate the association of serum neurotrophic factors and some gastric...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2022-03-01
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| Series: | Journal of Cardiovascular and Thoracic Research |
| Subjects: | |
| Online Access: | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-14-53.pdf |
| _version_ | 1818269600227262464 |
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| author | Reihaneh Zeinalian Dorsa Arman Moghadam Naseh Pahlavani Neda Roshanravan Mohammad Alizadeh Masoumeh Jabbari Sorayya Kheirouri |
| author_facet | Reihaneh Zeinalian Dorsa Arman Moghadam Naseh Pahlavani Neda Roshanravan Mohammad Alizadeh Masoumeh Jabbari Sorayya Kheirouri |
| author_sort | Reihaneh Zeinalian |
| collection | DOAJ |
| description | Introduction: Although, some evidence has shown that obestatin, ghrelin, and neurotrophic factors can be involved in the development of cardio-metabolic risk factors, there are some contradictions in this regard. We aimed to investigate the association of serum neurotrophic factors and some gastric hormones with cardio-metabolic risk factors among apparently healthy women. Methods: In the present study, 90 apparently healthy women were recruited by a convenient sampling method from the nutrition counseling clinic in Tabriz, Iran. All participants need dietary counseling for weight loss and were recruited before receiving any dietary interventions. Anthropometric, biochemical, physical activity, and blood pressure (BP) measurements, as well as dietary assessment, were done in all participants. Results: Women who were in the highest tertile of serum obestatin levels (OR=0.118, 95% CI:0.035-0.396) had a significantly lower risk for development of hypertriglyceridemia compared to the reference group (P trend<0.001). Participants in the highest tertile of serum ghrelin had a significant lower risk of hypertriglyceridemia, hyperglycemia, low HDL-C, and MetS (Ptrend<0.05). Women who were in the higher tertile of serum NGF levels had a significantly lower risk for development of hypertriglyceridemia after adjustment for potential confounding variables (OR=0.091, 95% CI: 0.023-0.361 and OR=0.193, 95% CI: 0.057-0.649 respectively). Conclusion: In the current study serum levels of obestatin, NGF, and ghrelin were associated with some cardio-metabolic risk factors such as hypertriglyceridemia and MetS. It seems that these factors are associated with metabolic regulation. However, further studies are needed to substantiate this claim. |
| first_indexed | 2024-12-12T20:56:58Z |
| format | Article |
| id | doaj.art-945511656cc94a9c9c2a2e193cf79f0d |
| institution | Directory Open Access Journal |
| issn | 2008-5117 2008-6830 |
| language | English |
| last_indexed | 2024-12-12T20:56:58Z |
| publishDate | 2022-03-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Cardiovascular and Thoracic Research |
| spelling | doaj.art-945511656cc94a9c9c2a2e193cf79f0d2022-12-22T00:12:16ZengTabriz University of Medical SciencesJournal of Cardiovascular and Thoracic Research2008-51172008-68302022-03-01141536010.34172/jcvtr.2022.10jcvtr-30419Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysisReihaneh Zeinalian0Dorsa Arman Moghadam1Naseh Pahlavani2Neda Roshanravan3Mohammad Alizadeh4Masoumeh Jabbari5Sorayya Kheirouri6Department of Nutrition in Community, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Nutrition, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IranCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, IranNutrition Research Center, Tabriz University of Medical Sciences, Tabriz, IranFaculty of Nutrition Sciences and Food Industry, Department of Community Nutrition, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, IranIntroduction: Although, some evidence has shown that obestatin, ghrelin, and neurotrophic factors can be involved in the development of cardio-metabolic risk factors, there are some contradictions in this regard. We aimed to investigate the association of serum neurotrophic factors and some gastric hormones with cardio-metabolic risk factors among apparently healthy women. Methods: In the present study, 90 apparently healthy women were recruited by a convenient sampling method from the nutrition counseling clinic in Tabriz, Iran. All participants need dietary counseling for weight loss and were recruited before receiving any dietary interventions. Anthropometric, biochemical, physical activity, and blood pressure (BP) measurements, as well as dietary assessment, were done in all participants. Results: Women who were in the highest tertile of serum obestatin levels (OR=0.118, 95% CI:0.035-0.396) had a significantly lower risk for development of hypertriglyceridemia compared to the reference group (P trend<0.001). Participants in the highest tertile of serum ghrelin had a significant lower risk of hypertriglyceridemia, hyperglycemia, low HDL-C, and MetS (Ptrend<0.05). Women who were in the higher tertile of serum NGF levels had a significantly lower risk for development of hypertriglyceridemia after adjustment for potential confounding variables (OR=0.091, 95% CI: 0.023-0.361 and OR=0.193, 95% CI: 0.057-0.649 respectively). Conclusion: In the current study serum levels of obestatin, NGF, and ghrelin were associated with some cardio-metabolic risk factors such as hypertriglyceridemia and MetS. It seems that these factors are associated with metabolic regulation. However, further studies are needed to substantiate this claim.https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-14-53.pdfcardio-metabolicngfbdnfghrelinobestatin |
| spellingShingle | Reihaneh Zeinalian Dorsa Arman Moghadam Naseh Pahlavani Neda Roshanravan Mohammad Alizadeh Masoumeh Jabbari Sorayya Kheirouri Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysis Journal of Cardiovascular and Thoracic Research cardio-metabolic ngf bdnf ghrelin obestatin |
| title | Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysis |
| title_full | Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysis |
| title_fullStr | Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysis |
| title_full_unstemmed | Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysis |
| title_short | Investigation of the association between cardio-metabolic risk factors, neurotrophins and gastric hormones among apparently healthy women: A cross-sectional analysis |
| title_sort | investigation of the association between cardio metabolic risk factors neurotrophins and gastric hormones among apparently healthy women a cross sectional analysis |
| topic | cardio-metabolic ngf bdnf ghrelin obestatin |
| url | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-14-53.pdf |
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