Calcium-mediated shaping of naive CD4 T-cell phenotype and function

Calcium-mediated shaping of naive CD4 T-cell phenotype and function

Continuous contact with self-major histocompatibility complex ligands is essential for the survival of naive CD4 T cells. We have previously shown that the resulting tonic TCR signaling also influences their fate upon activation by increasing their ability to differentiate into induced/peripheral re...

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Bibliographic Details
Main Authors: Vincent Guichard, Nelly Bonilla, Aurélie Durand, Alexandra Audemard-Verger, Thomas Guilbert, Bruno Martin, Bruno Lucas, Cédric Auffray
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
Naive CD4 T cells
induced regulatory T cells
differentiation
calcium signaling
self-reactivity
Online Access:https://elifesciences.org/articles/27215

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