Evaluation of Simplified Diet Scores Related to <i>C</i>-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening
The aim of this study was to assess the relationship between adherence to a healthy diet, such as the Mediterranean diet (MedDiet), and <i>C</i>-reactive protein (CRP) in Italian heavy smokers undergoing an LDCT screening program (bioMILD trial), using scores calculated by simple questio...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/20/4312 |
| _version_ | 1797470620465758208 |
|---|---|
| author | Federica Sabia Alessandra Borgo Alessandra Lugo Paola Suatoni Daniele Morelli Silvano Gallus Anna Villarini Ugo Pastorino |
| author_facet | Federica Sabia Alessandra Borgo Alessandra Lugo Paola Suatoni Daniele Morelli Silvano Gallus Anna Villarini Ugo Pastorino |
| author_sort | Federica Sabia |
| collection | DOAJ |
| description | The aim of this study was to assess the relationship between adherence to a healthy diet, such as the Mediterranean diet (MedDiet), and <i>C</i>-reactive protein (CRP) in Italian heavy smokers undergoing an LDCT screening program (bioMILD trial), using scores calculated by simple questionnaires. Simple formats of food frequency questionnaires were administered to a sample of 2438 volunteers, and the adherence to a healthy diet was measured by the validated 14-point MEDAS and by two adaptations proposed by us: 17-item revised-MEDAS and 18-item revised-MEDAS. The OR of CRP ≥ 2 mg/L for 1-point increase in 14-point MEDAS score was 0.95 (95% CI 0.91–0.99), for 17-point score was 0.94 (95% CI 0.91–0.98), and for 18-point score was 0.92 (95% CI 0.88–0.97). These inverse associations remained statistically significant also after further adjustment for body mass index. These results showed the efficacy of simplified scores and their relationship with lower levels of CRP in a population of heavy smokers. This suggests that a targeted nutritional intervention might achieve a substantial reduction in CRP levels. The findings will be prospectively tested in a new randomized study on primary prevention during lung cancer screening. |
| first_indexed | 2024-03-09T19:39:36Z |
| format | Article |
| id | doaj.art-9459735a29ff413fa2f9d3573725fba0 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T19:39:36Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-9459735a29ff413fa2f9d3573725fba02023-11-24T01:44:20ZengMDPI AGNutrients2072-66432022-10-011420431210.3390/nu14204312Evaluation of Simplified Diet Scores Related to <i>C</i>-Reactive Protein in Heavy Smokers Undergoing Lung Cancer ScreeningFederica Sabia0Alessandra Borgo1Alessandra Lugo2Paola Suatoni3Daniele Morelli4Silvano Gallus5Anna Villarini6Ugo Pastorino7Thoracic Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, ItalyThoracic Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, ItalyDepartment of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, ItalyThoracic Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, ItalyLaboratory Medicine Unit, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, ItalyDepartment of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, ItalyDepartment of Research, S.S.D. Valitative Epidemiology, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, ItalyThoracic Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, ItalyThe aim of this study was to assess the relationship between adherence to a healthy diet, such as the Mediterranean diet (MedDiet), and <i>C</i>-reactive protein (CRP) in Italian heavy smokers undergoing an LDCT screening program (bioMILD trial), using scores calculated by simple questionnaires. Simple formats of food frequency questionnaires were administered to a sample of 2438 volunteers, and the adherence to a healthy diet was measured by the validated 14-point MEDAS and by two adaptations proposed by us: 17-item revised-MEDAS and 18-item revised-MEDAS. The OR of CRP ≥ 2 mg/L for 1-point increase in 14-point MEDAS score was 0.95 (95% CI 0.91–0.99), for 17-point score was 0.94 (95% CI 0.91–0.98), and for 18-point score was 0.92 (95% CI 0.88–0.97). These inverse associations remained statistically significant also after further adjustment for body mass index. These results showed the efficacy of simplified scores and their relationship with lower levels of CRP in a population of heavy smokers. This suggests that a targeted nutritional intervention might achieve a substantial reduction in CRP levels. The findings will be prospectively tested in a new randomized study on primary prevention during lung cancer screening.https://www.mdpi.com/2072-6643/14/20/4312diet score<i>C</i>-reactive proteininflammationheavy smokerslung cancer screening |
| spellingShingle | Federica Sabia Alessandra Borgo Alessandra Lugo Paola Suatoni Daniele Morelli Silvano Gallus Anna Villarini Ugo Pastorino Evaluation of Simplified Diet Scores Related to <i>C</i>-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening Nutrients diet score <i>C</i>-reactive protein inflammation heavy smokers lung cancer screening |
| title | Evaluation of Simplified Diet Scores Related to <i>C</i>-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening |
| title_full | Evaluation of Simplified Diet Scores Related to <i>C</i>-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening |
| title_fullStr | Evaluation of Simplified Diet Scores Related to <i>C</i>-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening |
| title_full_unstemmed | Evaluation of Simplified Diet Scores Related to <i>C</i>-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening |
| title_short | Evaluation of Simplified Diet Scores Related to <i>C</i>-Reactive Protein in Heavy Smokers Undergoing Lung Cancer Screening |
| title_sort | evaluation of simplified diet scores related to i c i reactive protein in heavy smokers undergoing lung cancer screening |
| topic | diet score <i>C</i>-reactive protein inflammation heavy smokers lung cancer screening |
| url | https://www.mdpi.com/2072-6643/14/20/4312 |
| work_keys_str_mv | AT federicasabia evaluationofsimplifieddietscoresrelatedtoicireactiveproteininheavysmokersundergoinglungcancerscreening AT alessandraborgo evaluationofsimplifieddietscoresrelatedtoicireactiveproteininheavysmokersundergoinglungcancerscreening AT alessandralugo evaluationofsimplifieddietscoresrelatedtoicireactiveproteininheavysmokersundergoinglungcancerscreening AT paolasuatoni evaluationofsimplifieddietscoresrelatedtoicireactiveproteininheavysmokersundergoinglungcancerscreening AT danielemorelli evaluationofsimplifieddietscoresrelatedtoicireactiveproteininheavysmokersundergoinglungcancerscreening AT silvanogallus evaluationofsimplifieddietscoresrelatedtoicireactiveproteininheavysmokersundergoinglungcancerscreening AT annavillarini evaluationofsimplifieddietscoresrelatedtoicireactiveproteininheavysmokersundergoinglungcancerscreening AT ugopastorino evaluationofsimplifieddietscoresrelatedtoicireactiveproteininheavysmokersundergoinglungcancerscreening |