Three New Benzophenone Derivatives from <i>Selaginella tamariscina</i>
Six compounds including three new benzophenones, selagibenzophenones D-F (<b>1</b>–<b>3</b>), two known selaginellins (<b>4</b>–<b>5</b>) and one known flavonoid (<b>6</b>), were isolated from <i>Selaginella tamariscina</i>. The...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/12/4582 |
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| author | Jiayin Long Qingqing Mao Yujie Peng Lei Liu Yin Hong Honglin Xiang Ming Ma Hui Zou Junwei Kuang |
| author_facet | Jiayin Long Qingqing Mao Yujie Peng Lei Liu Yin Hong Honglin Xiang Ming Ma Hui Zou Junwei Kuang |
| author_sort | Jiayin Long |
| collection | DOAJ |
| description | Six compounds including three new benzophenones, selagibenzophenones D-F (<b>1</b>–<b>3</b>), two known selaginellins (<b>4</b>–<b>5</b>) and one known flavonoid (<b>6</b>), were isolated from <i>Selaginella tamariscina</i>. The structures of new compounds were established by 1D-, 2D-NMR and HR-ESI-MS spectral analyses. Compound <b>1</b> represents the second example of diarylbenzophenone from natural sources. Compound <b>2</b> possesses an unusual biphenyl-bisbenzophenone structure. Their cytotoxicity against human hepatocellular carcinoma HepG2 and SMCC-7721 cells and inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells were evaluated. Compound <b>2</b> showed moderate inhibitory activity against HepG2 and SMCC-7721 cells, and compounds <b>4</b> and <b>5</b> showed moderate inhibitory activity to HepG2 cells. Compounds <b>2</b> and <b>5</b> also exhibited inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production. |
| first_indexed | 2024-03-11T02:07:30Z |
| format | Article |
| id | doaj.art-945b33d2caa142c5aa1276ef15532be0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T02:07:30Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-945b33d2caa142c5aa1276ef15532be02023-11-18T11:47:36ZengMDPI AGMolecules1420-30492023-06-012812458210.3390/molecules28124582Three New Benzophenone Derivatives from <i>Selaginella tamariscina</i>Jiayin Long0Qingqing Mao1Yujie Peng2Lei Liu3Yin Hong4Honglin Xiang5Ming Ma6Hui Zou7Junwei Kuang8Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410013, ChinaKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410013, ChinaKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410013, ChinaKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410013, ChinaKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410013, ChinaKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410013, ChinaKey Laboratory of Phytochemical R&D of Hunan Province, Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research of Ministry of Education, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, ChinaKey Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410013, ChinaKey Laboratory of Phytochemical R&D of Hunan Province, Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research of Ministry of Education, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, ChinaSix compounds including three new benzophenones, selagibenzophenones D-F (<b>1</b>–<b>3</b>), two known selaginellins (<b>4</b>–<b>5</b>) and one known flavonoid (<b>6</b>), were isolated from <i>Selaginella tamariscina</i>. The structures of new compounds were established by 1D-, 2D-NMR and HR-ESI-MS spectral analyses. Compound <b>1</b> represents the second example of diarylbenzophenone from natural sources. Compound <b>2</b> possesses an unusual biphenyl-bisbenzophenone structure. Their cytotoxicity against human hepatocellular carcinoma HepG2 and SMCC-7721 cells and inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells were evaluated. Compound <b>2</b> showed moderate inhibitory activity against HepG2 and SMCC-7721 cells, and compounds <b>4</b> and <b>5</b> showed moderate inhibitory activity to HepG2 cells. Compounds <b>2</b> and <b>5</b> also exhibited inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production.https://www.mdpi.com/1420-3049/28/12/4582<i>Selaginella</i><i>Selaginella tamariscina</i>benzophenoneselagibenzophenones D-FcytotoxicityNO inhibitory effects |
| spellingShingle | Jiayin Long Qingqing Mao Yujie Peng Lei Liu Yin Hong Honglin Xiang Ming Ma Hui Zou Junwei Kuang Three New Benzophenone Derivatives from <i>Selaginella tamariscina</i> Molecules <i>Selaginella</i> <i>Selaginella tamariscina</i> benzophenone selagibenzophenones D-F cytotoxicity NO inhibitory effects |
| title | Three New Benzophenone Derivatives from <i>Selaginella tamariscina</i> |
| title_full | Three New Benzophenone Derivatives from <i>Selaginella tamariscina</i> |
| title_fullStr | Three New Benzophenone Derivatives from <i>Selaginella tamariscina</i> |
| title_full_unstemmed | Three New Benzophenone Derivatives from <i>Selaginella tamariscina</i> |
| title_short | Three New Benzophenone Derivatives from <i>Selaginella tamariscina</i> |
| title_sort | three new benzophenone derivatives from i selaginella tamariscina i |
| topic | <i>Selaginella</i> <i>Selaginella tamariscina</i> benzophenone selagibenzophenones D-F cytotoxicity NO inhibitory effects |
| url | https://www.mdpi.com/1420-3049/28/12/4582 |
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