Could platelet distribution width predict coronary collateral development in stable coronary artery disease?
OBJECTIVE: We hypothesized that hemogram parameters should be related to the development of coronary collateral vessels. For this purpose, we aimed to compare platelet distribution width (PDW) and PDW to platelet ratio (PPR) in subjects with stable coronary artery disease having adequate or inadequa...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KARE Publishing
2020-03-01
|
| Series: | İstanbul Kuzey Klinikleri |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-47374 |
| _version_ | 1797913858651717632 |
|---|---|
| author | Isa Sincer Asli Kurtar Mansiroglu Emrah Erdal Mehmet Cosgun Gulali Aktas Yilmaz Gunes |
| author_facet | Isa Sincer Asli Kurtar Mansiroglu Emrah Erdal Mehmet Cosgun Gulali Aktas Yilmaz Gunes |
| author_sort | Isa Sincer |
| collection | DOAJ |
| description | OBJECTIVE: We hypothesized that hemogram parameters should be related to the development of coronary collateral vessels. For this purpose, we aimed to compare platelet distribution width (PDW) and PDW to platelet ratio (PPR) in subjects with stable coronary artery disease having adequate or inadequate coronary collateral development.
METHODS: A total of 398 patients with stable angina pectoris undergoing coronary angiography were enrolled and divided on the basis of the development of coronary collateral (CCD) (inadequate CCD (n=267) and adequate CCD (n=131). Routine complete blood count and biochemical parameters were measured before coronary arteriography.
RESULTS: Mean PDW and PPR values of inadequate and adequate CCD groups were 17.5% (10–23) and 12.4% (9.8–22) %, p<0.001, respectively. In multivariate analysis, age (p=0.012, 95% CI for OR: 0.958 (0.933–0.983) and PDW (p<0.001, 95% CI for OR: 1.432 (1.252–1.618) were found to be statistically significantly different inadequate CCD group compared to adequate CCD group. Receiver operating curve (ROC) analyses revealed that a PPR value greater than 0.057 had 76% sensitivity and 51% specificity and a PDW higher than 16.2% had 80% sensitivity and 66% specificity in predicting inadequate CCD.
CONCLUSION: The present study suggests that PDW and PPR may be associated with the degree of collateral development in chronic stable coronary artery disease (CAD). |
| first_indexed | 2024-04-10T12:18:00Z |
| format | Article |
| id | doaj.art-945b58e9f5754d318c44172d9ac29a60 |
| institution | Directory Open Access Journal |
| issn | 2148-4902 |
| language | English |
| last_indexed | 2024-04-10T12:18:00Z |
| publishDate | 2020-03-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | İstanbul Kuzey Klinikleri |
| spelling | doaj.art-945b58e9f5754d318c44172d9ac29a602023-02-15T16:15:36ZengKARE Publishingİstanbul Kuzey Klinikleri2148-49022020-03-017211211710.14744/nci.2019.47374NCI-47374Could platelet distribution width predict coronary collateral development in stable coronary artery disease?Isa Sincer0Asli Kurtar Mansiroglu1Emrah Erdal2Mehmet Cosgun3Gulali Aktas4Yilmaz Gunes5Department of Cardiology, Abant Izzet Baysal University Faculty of Medicine Hospital, Bolu, TurkeyDepartment of Cardiology, Abant Izzet Baysal University Faculty of Medicine Hospital, Bolu, TurkeyDepartment of Cardiology, Abant Izzet Baysal University Faculty of Medicine Hospital, Bolu, TurkeyDepartment of Cardiology, Abant Izzet Baysal University Faculty of Medicine Hospital, Bolu, TurkeyDepartment of Internal Medicine, Abant Izzet Baysal University Faculty of Medicine Hospital, Bolu, TurkeyDepartment of Cardiology, Abant Izzet Baysal University Faculty of Medicine Hospital, Bolu, TurkeyOBJECTIVE: We hypothesized that hemogram parameters should be related to the development of coronary collateral vessels. For this purpose, we aimed to compare platelet distribution width (PDW) and PDW to platelet ratio (PPR) in subjects with stable coronary artery disease having adequate or inadequate coronary collateral development. METHODS: A total of 398 patients with stable angina pectoris undergoing coronary angiography were enrolled and divided on the basis of the development of coronary collateral (CCD) (inadequate CCD (n=267) and adequate CCD (n=131). Routine complete blood count and biochemical parameters were measured before coronary arteriography. RESULTS: Mean PDW and PPR values of inadequate and adequate CCD groups were 17.5% (10–23) and 12.4% (9.8–22) %, p<0.001, respectively. In multivariate analysis, age (p=0.012, 95% CI for OR: 0.958 (0.933–0.983) and PDW (p<0.001, 95% CI for OR: 1.432 (1.252–1.618) were found to be statistically significantly different inadequate CCD group compared to adequate CCD group. Receiver operating curve (ROC) analyses revealed that a PPR value greater than 0.057 had 76% sensitivity and 51% specificity and a PDW higher than 16.2% had 80% sensitivity and 66% specificity in predicting inadequate CCD. CONCLUSION: The present study suggests that PDW and PPR may be associated with the degree of collateral development in chronic stable coronary artery disease (CAD).https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-47374coronary collateral developmentplatelet distribution width; platelet distribution width to platelet ratio; stable coronary artery disease. |
| spellingShingle | Isa Sincer Asli Kurtar Mansiroglu Emrah Erdal Mehmet Cosgun Gulali Aktas Yilmaz Gunes Could platelet distribution width predict coronary collateral development in stable coronary artery disease? İstanbul Kuzey Klinikleri coronary collateral development platelet distribution width; platelet distribution width to platelet ratio; stable coronary artery disease. |
| title | Could platelet distribution width predict coronary collateral development in stable coronary artery disease? |
| title_full | Could platelet distribution width predict coronary collateral development in stable coronary artery disease? |
| title_fullStr | Could platelet distribution width predict coronary collateral development in stable coronary artery disease? |
| title_full_unstemmed | Could platelet distribution width predict coronary collateral development in stable coronary artery disease? |
| title_short | Could platelet distribution width predict coronary collateral development in stable coronary artery disease? |
| title_sort | could platelet distribution width predict coronary collateral development in stable coronary artery disease |
| topic | coronary collateral development platelet distribution width; platelet distribution width to platelet ratio; stable coronary artery disease. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-47374 |
| work_keys_str_mv | AT isasincer couldplateletdistributionwidthpredictcoronarycollateraldevelopmentinstablecoronaryarterydisease AT aslikurtarmansiroglu couldplateletdistributionwidthpredictcoronarycollateraldevelopmentinstablecoronaryarterydisease AT emraherdal couldplateletdistributionwidthpredictcoronarycollateraldevelopmentinstablecoronaryarterydisease AT mehmetcosgun couldplateletdistributionwidthpredictcoronarycollateraldevelopmentinstablecoronaryarterydisease AT gulaliaktas couldplateletdistributionwidthpredictcoronarycollateraldevelopmentinstablecoronaryarterydisease AT yilmazgunes couldplateletdistributionwidthpredictcoronarycollateraldevelopmentinstablecoronaryarterydisease |