Bradycardia Caused by interaction of Venlafaxine and Cyclosporine: A case report
Background: Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are prescribed widely for the treatment of depression, anxiety disorders and other psychiatric disorders. Although antidepressants are considered as a safety drug category but unexpec...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2019-09-01
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| Series: | Caspian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://caspjim.com/article-1-1321-en.html |
| _version_ | 1828445404585263104 |
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| author | Marzieh Azizi Forouzan Elyasi fatemeh Niksolat Roodposhti |
| author_facet | Marzieh Azizi Forouzan Elyasi fatemeh Niksolat Roodposhti |
| author_sort | Marzieh Azizi |
| collection | DOAJ |
| description | Background: Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are prescribed widely for the treatment of depression, anxiety disorders and other psychiatric disorders. Although antidepressants are considered as a safety drug category but unexpected cardiovascular events have been reported as the most serious complications. The aim of this study was to introduce a case presentation on bradycardia due to the drug interference of venlafaxine and cyclosporine.
Case presentation: The patient was a 38-year old woman diagnosed with systemic lupus erythematosus 5 years ago, who was admitted to a general educational hospital in northern Iran due to intensified rheumatologic symptoms and complaining about abdominal pain. Cyclosporine tab were administered to the patient, 50 mg twice daily. Two weeks after the administration of cyclosporine, the level of blood cyclosporine was checked. The patient became bradycardic after starting a single dose of venlafaxine (heart rate 52 ppm). Cardiac assessment showed no reason for bradycardia and it subsided after a drop of venlafaxine.
Conclusion: As a result of the potential adverse drug interactions between cyclosporine and antidepressants such as venlafaxine, physicians should be aware of the possibility of bradycardia in the simultaneous prescription of these drugs in cases. |
| first_indexed | 2024-12-10T21:57:37Z |
| format | Article |
| id | doaj.art-945cbaef24384929950b1d629dd153a1 |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-12-10T21:57:37Z |
| publishDate | 2019-09-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-945cbaef24384929950b1d629dd153a12022-12-22T01:32:00ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722019-09-01104463467Bradycardia Caused by interaction of Venlafaxine and Cyclosporine: A case reportMarzieh Azizi0Forouzan Elyasi1fatemeh Niksolat Roodposhti2 Sexual and Reproductive Health Research Center, Nasibeh Nursing and Midwifery Faculty, Mazandaran University of Medical Sciences, Sari, Iran Department of Psychiatry, Psychiatry and Behavioral Sciences Research Center and addiction Institute, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Department of Internal Medicine, Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran Background: Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are prescribed widely for the treatment of depression, anxiety disorders and other psychiatric disorders. Although antidepressants are considered as a safety drug category but unexpected cardiovascular events have been reported as the most serious complications. The aim of this study was to introduce a case presentation on bradycardia due to the drug interference of venlafaxine and cyclosporine. Case presentation: The patient was a 38-year old woman diagnosed with systemic lupus erythematosus 5 years ago, who was admitted to a general educational hospital in northern Iran due to intensified rheumatologic symptoms and complaining about abdominal pain. Cyclosporine tab were administered to the patient, 50 mg twice daily. Two weeks after the administration of cyclosporine, the level of blood cyclosporine was checked. The patient became bradycardic after starting a single dose of venlafaxine (heart rate 52 ppm). Cardiac assessment showed no reason for bradycardia and it subsided after a drop of venlafaxine. Conclusion: As a result of the potential adverse drug interactions between cyclosporine and antidepressants such as venlafaxine, physicians should be aware of the possibility of bradycardia in the simultaneous prescription of these drugs in cases.http://caspjim.com/article-1-1321-en.htmlbradycardiavenlafaxinecyclosporineserotonin-norepinephrine reuptake inhibitorsselective serotonin reuptake inhibitors. |
| spellingShingle | Marzieh Azizi Forouzan Elyasi fatemeh Niksolat Roodposhti Bradycardia Caused by interaction of Venlafaxine and Cyclosporine: A case report Caspian Journal of Internal Medicine bradycardia venlafaxine cyclosporine serotonin-norepinephrine reuptake inhibitors selective serotonin reuptake inhibitors. |
| title | Bradycardia Caused by interaction of Venlafaxine and Cyclosporine: A case report |
| title_full | Bradycardia Caused by interaction of Venlafaxine and Cyclosporine: A case report |
| title_fullStr | Bradycardia Caused by interaction of Venlafaxine and Cyclosporine: A case report |
| title_full_unstemmed | Bradycardia Caused by interaction of Venlafaxine and Cyclosporine: A case report |
| title_short | Bradycardia Caused by interaction of Venlafaxine and Cyclosporine: A case report |
| title_sort | bradycardia caused by interaction of venlafaxine and cyclosporine a case report |
| topic | bradycardia venlafaxine cyclosporine serotonin-norepinephrine reuptake inhibitors selective serotonin reuptake inhibitors. |
| url | http://caspjim.com/article-1-1321-en.html |
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