Progress of Whole Exon Sequencing in Pathogenesis and Diagnosis of Breast Cancer
Whole exon sequencing is a genomic analysis method that uses sequence capture technology to capture and enrich the whole genome exon region DNA for high-throughput sequencing. This technology has been applied to gene diagnosis and treatment of various complex diseases. At present, the pathogenesis o...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2019-05-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2019.18.1394.htm |
| _version_ | 1818329258875944960 |
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| author | JIN Weihua ZHANG Ruitao |
| author_facet | JIN Weihua ZHANG Ruitao |
| author_sort | JIN Weihua |
| collection | DOAJ |
| description | Whole exon sequencing is a genomic analysis method that uses sequence capture technology to capture and enrich the whole genome exon region DNA for high-throughput sequencing. This technology has been applied to gene diagnosis and treatment of various complex diseases. At present, the pathogenesis of breast cancer has not been clearly elucidated, and the activation of oncogenes and the inactivation of tumor suppressor genes caused by gene mutation of somatic cells play a crucial role in the development of breast cancer. In recent years, numerous research groups have carried out a large number of whole exon sequencing researches, found and identified many genetic mutations associated with complex diseases/traits, which provide important clues for the study of the pathogenesis of complex diseases. This paper reviews the pathogenesis and diagnosis and treatment of breast cancer by whole exon sequencing. |
| first_indexed | 2024-12-13T12:45:12Z |
| format | Article |
| id | doaj.art-945e69f555ff4fc0bae83c9b2d24a2cf |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-12-13T12:45:12Z |
| publishDate | 2019-05-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-945e69f555ff4fc0bae83c9b2d24a2cf2022-12-21T23:45:31ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782019-05-0146548248510.3971/j.issn.1000-8578.2019.18.13948578.2019.18.1394Progress of Whole Exon Sequencing in Pathogenesis and Diagnosis of Breast CancerJIN Weihua0ZHANG Ruitao1Department of Anatomy and Tissue Embryology, Medical College of China Three Gorges University, Yichang 443000, ChinaDepartment of Anatomy and Tissue Embryology, Medical College of China Three Gorges University, Yichang 443000, ChinaWhole exon sequencing is a genomic analysis method that uses sequence capture technology to capture and enrich the whole genome exon region DNA for high-throughput sequencing. This technology has been applied to gene diagnosis and treatment of various complex diseases. At present, the pathogenesis of breast cancer has not been clearly elucidated, and the activation of oncogenes and the inactivation of tumor suppressor genes caused by gene mutation of somatic cells play a crucial role in the development of breast cancer. In recent years, numerous research groups have carried out a large number of whole exon sequencing researches, found and identified many genetic mutations associated with complex diseases/traits, which provide important clues for the study of the pathogenesis of complex diseases. This paper reviews the pathogenesis and diagnosis and treatment of breast cancer by whole exon sequencing.http://html.rhhz.net/ZLFZYJ/html/8578.2019.18.1394.htmwhole exon sequencingbreast cancerpathogenesisdiagnosistreatment |
| spellingShingle | JIN Weihua ZHANG Ruitao Progress of Whole Exon Sequencing in Pathogenesis and Diagnosis of Breast Cancer Zhongliu Fangzhi Yanjiu whole exon sequencing breast cancer pathogenesis diagnosis treatment |
| title | Progress of Whole Exon Sequencing in Pathogenesis and Diagnosis of Breast Cancer |
| title_full | Progress of Whole Exon Sequencing in Pathogenesis and Diagnosis of Breast Cancer |
| title_fullStr | Progress of Whole Exon Sequencing in Pathogenesis and Diagnosis of Breast Cancer |
| title_full_unstemmed | Progress of Whole Exon Sequencing in Pathogenesis and Diagnosis of Breast Cancer |
| title_short | Progress of Whole Exon Sequencing in Pathogenesis and Diagnosis of Breast Cancer |
| title_sort | progress of whole exon sequencing in pathogenesis and diagnosis of breast cancer |
| topic | whole exon sequencing breast cancer pathogenesis diagnosis treatment |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2019.18.1394.htm |
| work_keys_str_mv | AT jinweihua progressofwholeexonsequencinginpathogenesisanddiagnosisofbreastcancer AT zhangruitao progressofwholeexonsequencinginpathogenesisanddiagnosisofbreastcancer |