Secretory IgA in Intestinal Mucosal Secretions as an Adaptive Barrier against Microbial Cells
Secretory IgA (SIgA) is the dominant antibody class in mucosal secretions. The majority of plasma cells producing IgA are located within mucosal membranes lining the intestines. SIgA protects against the adhesion of pathogens and their penetration into the intestinal barrier. Moreover, SIgA regulate...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/23/9254 |
| _version_ | 1797545765245026304 |
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| author | Bernadeta Pietrzak Katarzyna Tomela Agnieszka Olejnik-Schmidt Andrzej Mackiewicz Marcin Schmidt |
| author_facet | Bernadeta Pietrzak Katarzyna Tomela Agnieszka Olejnik-Schmidt Andrzej Mackiewicz Marcin Schmidt |
| author_sort | Bernadeta Pietrzak |
| collection | DOAJ |
| description | Secretory IgA (SIgA) is the dominant antibody class in mucosal secretions. The majority of plasma cells producing IgA are located within mucosal membranes lining the intestines. SIgA protects against the adhesion of pathogens and their penetration into the intestinal barrier. Moreover, SIgA regulates gut microbiota composition and provides intestinal homeostasis. In this review, we present mechanisms of SIgA generation: T cell-dependent and -independent; in different non-organized and organized lymphoid structures in intestinal lamina propria (i.e., Peyer’s patches and isolated lymphoid follicles). We also summarize recent advances in understanding of SIgA functions in intestinal mucosal secretions with focus on its role in regulating gut microbiota composition and generation of tolerogenic responses toward its members. |
| first_indexed | 2024-03-10T14:19:36Z |
| format | Article |
| id | doaj.art-945ea4fd0bb44833a3252b672cb7b80f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:19:36Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-945ea4fd0bb44833a3252b672cb7b80f2023-11-20T23:28:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-012123925410.3390/ijms21239254Secretory IgA in Intestinal Mucosal Secretions as an Adaptive Barrier against Microbial CellsBernadeta Pietrzak0Katarzyna Tomela1Agnieszka Olejnik-Schmidt2Andrzej Mackiewicz3Marcin Schmidt4Department of Food Biotechnology and Microbiology, Poznan University of Life Sciences, 48 Wojska Polskiego, 60-627 Poznań, PolandDepartment of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, 8 Rokietnicka Street, 60-806 Poznań, PolandDepartment of Food Biotechnology and Microbiology, Poznan University of Life Sciences, 48 Wojska Polskiego, 60-627 Poznań, PolandDepartment of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, 8 Rokietnicka Street, 60-806 Poznań, PolandDepartment of Food Biotechnology and Microbiology, Poznan University of Life Sciences, 48 Wojska Polskiego, 60-627 Poznań, PolandSecretory IgA (SIgA) is the dominant antibody class in mucosal secretions. The majority of plasma cells producing IgA are located within mucosal membranes lining the intestines. SIgA protects against the adhesion of pathogens and their penetration into the intestinal barrier. Moreover, SIgA regulates gut microbiota composition and provides intestinal homeostasis. In this review, we present mechanisms of SIgA generation: T cell-dependent and -independent; in different non-organized and organized lymphoid structures in intestinal lamina propria (i.e., Peyer’s patches and isolated lymphoid follicles). We also summarize recent advances in understanding of SIgA functions in intestinal mucosal secretions with focus on its role in regulating gut microbiota composition and generation of tolerogenic responses toward its members.https://www.mdpi.com/1422-0067/21/23/9254secretory immunoglobulin Agutmicrobiotaimmune homeostasismucosal secretionstolerance |
| spellingShingle | Bernadeta Pietrzak Katarzyna Tomela Agnieszka Olejnik-Schmidt Andrzej Mackiewicz Marcin Schmidt Secretory IgA in Intestinal Mucosal Secretions as an Adaptive Barrier against Microbial Cells International Journal of Molecular Sciences secretory immunoglobulin A gut microbiota immune homeostasis mucosal secretions tolerance |
| title | Secretory IgA in Intestinal Mucosal Secretions as an Adaptive Barrier against Microbial Cells |
| title_full | Secretory IgA in Intestinal Mucosal Secretions as an Adaptive Barrier against Microbial Cells |
| title_fullStr | Secretory IgA in Intestinal Mucosal Secretions as an Adaptive Barrier against Microbial Cells |
| title_full_unstemmed | Secretory IgA in Intestinal Mucosal Secretions as an Adaptive Barrier against Microbial Cells |
| title_short | Secretory IgA in Intestinal Mucosal Secretions as an Adaptive Barrier against Microbial Cells |
| title_sort | secretory iga in intestinal mucosal secretions as an adaptive barrier against microbial cells |
| topic | secretory immunoglobulin A gut microbiota immune homeostasis mucosal secretions tolerance |
| url | https://www.mdpi.com/1422-0067/21/23/9254 |
| work_keys_str_mv | AT bernadetapietrzak secretoryigainintestinalmucosalsecretionsasanadaptivebarrieragainstmicrobialcells AT katarzynatomela secretoryigainintestinalmucosalsecretionsasanadaptivebarrieragainstmicrobialcells AT agnieszkaolejnikschmidt secretoryigainintestinalmucosalsecretionsasanadaptivebarrieragainstmicrobialcells AT andrzejmackiewicz secretoryigainintestinalmucosalsecretionsasanadaptivebarrieragainstmicrobialcells AT marcinschmidt secretoryigainintestinalmucosalsecretionsasanadaptivebarrieragainstmicrobialcells |