Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue

Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue

Abstract Background DNA methylation is an important epigenetic mechanism involved in gene regulation, with alterations in DNA methylation in the nuclear genome being linked to numerous complex diseases. Mitochondrial DNA methylation is a phenomenon that is receiving ever-increasing interest, particu...

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Bibliographic Details
Main Authors: Matthew Devall, Rebecca G. Smith, Aaron Jeffries, Eilis Hannon, Matthew N. Davies, Leonard Schalkwyk, Jonathan Mill, Michael Weedon, Katie Lunnon
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Clinical Epigenetics
Subjects:
5-mC
5-Methylcytosine
Blood
Brain
DNA methylation
Epigenetics
Online Access:http://link.springer.com/article/10.1186/s13148-017-0337-3

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