Non-contact optical in-vivo sensing of cilia motion by analyzing speckle patterns
Abstract Cilia motion is an indicator of pathological-ciliary function, however current diagnosis relies on biopsies. In this paper, we propose an innovative approach for sensing cilia motility. We present an endoscopic configuration for measuring the motion frequency of cilia in the nasal cavity. T...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-20557-1 |
| _version_ | 1811226616905334784 |
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| author | Doron Duadi Nadav Shabairou Adi Primov-Fever Zeev Zalevsky |
| author_facet | Doron Duadi Nadav Shabairou Adi Primov-Fever Zeev Zalevsky |
| author_sort | Doron Duadi |
| collection | DOAJ |
| description | Abstract Cilia motion is an indicator of pathological-ciliary function, however current diagnosis relies on biopsies. In this paper, we propose an innovative approach for sensing cilia motility. We present an endoscopic configuration for measuring the motion frequency of cilia in the nasal cavity. The technique is based on temporal tracking of the reflected spatial distribution of defocused speckle patterns while illuminating the cilia with a laser. The setup splits the optical signal into two channels; One imaging channel is for the visualization of the physician and another is, defocusing channel, to capture the speckles. We present in-vivo measurements from healthy subjects undergoing endoscopic examination. We found an average motion frequency of around 7.3 Hz and 9.8 Hz in the antero-posterior nasal mucus (an area rich in cilia), which matches the normal cilia range of 7–16 Hz. Quantitative and precise measurements of cilia vibration will optimize the diagnosis and treatment of pathological-ciliary function. This method is simple, minimally invasive, inexpensive, and promising to distinguish between normal and ciliary dysfunction. |
| first_indexed | 2024-04-12T09:28:08Z |
| format | Article |
| id | doaj.art-945f2b8bf8614dc5926e01ece232fe2d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T09:28:08Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-945f2b8bf8614dc5926e01ece232fe2d2022-12-22T03:38:26ZengNature PortfolioScientific Reports2045-23222022-10-011211710.1038/s41598-022-20557-1Non-contact optical in-vivo sensing of cilia motion by analyzing speckle patternsDoron Duadi0Nadav Shabairou1Adi Primov-Fever2Zeev Zalevsky3Faculty of Engineering and Institute of Nanotechnology and Advanced Materials, Bar Ilan UniversityFaculty of Engineering and Institute of Nanotechnology and Advanced Materials, Bar Ilan UniversityDepartment of Otolaryngology and Head and Neck Surgery, Sheba Medical Center, and Sackler School of Medicine, Tel-Aviv UniversityFaculty of Engineering and Institute of Nanotechnology and Advanced Materials, Bar Ilan UniversityAbstract Cilia motion is an indicator of pathological-ciliary function, however current diagnosis relies on biopsies. In this paper, we propose an innovative approach for sensing cilia motility. We present an endoscopic configuration for measuring the motion frequency of cilia in the nasal cavity. The technique is based on temporal tracking of the reflected spatial distribution of defocused speckle patterns while illuminating the cilia with a laser. The setup splits the optical signal into two channels; One imaging channel is for the visualization of the physician and another is, defocusing channel, to capture the speckles. We present in-vivo measurements from healthy subjects undergoing endoscopic examination. We found an average motion frequency of around 7.3 Hz and 9.8 Hz in the antero-posterior nasal mucus (an area rich in cilia), which matches the normal cilia range of 7–16 Hz. Quantitative and precise measurements of cilia vibration will optimize the diagnosis and treatment of pathological-ciliary function. This method is simple, minimally invasive, inexpensive, and promising to distinguish between normal and ciliary dysfunction.https://doi.org/10.1038/s41598-022-20557-1 |
| spellingShingle | Doron Duadi Nadav Shabairou Adi Primov-Fever Zeev Zalevsky Non-contact optical in-vivo sensing of cilia motion by analyzing speckle patterns Scientific Reports |
| title | Non-contact optical in-vivo sensing of cilia motion by analyzing speckle patterns |
| title_full | Non-contact optical in-vivo sensing of cilia motion by analyzing speckle patterns |
| title_fullStr | Non-contact optical in-vivo sensing of cilia motion by analyzing speckle patterns |
| title_full_unstemmed | Non-contact optical in-vivo sensing of cilia motion by analyzing speckle patterns |
| title_short | Non-contact optical in-vivo sensing of cilia motion by analyzing speckle patterns |
| title_sort | non contact optical in vivo sensing of cilia motion by analyzing speckle patterns |
| url | https://doi.org/10.1038/s41598-022-20557-1 |
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