The Use of ADSCs as a Treatment for Chronic Stroke
Stroke is one of the disorders for which clinically effective therapeutic modalities are most needed, and numerous ways have been explored to attempt to investigate their feasibilities. However, ischemic- or hemorrhagicinduced inflammatory neuron death causes irreversible injuries and infarction reg...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2014-05-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/096368914X678409 |
| _version_ | 1818313518374453248 |
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| author | Tzu-Min Chan Horng-Jyh Harn Hui-Ping Lin Shao-Chih Chiu Po-Cheng Lin Hsin-I Wang Li-Ing Ho Chih-Pin Chuu Tzyy-Wen Chiou An-Cheng Hsieh Yu-Wen Chen Wen-Yu Ho Shinn-Zong Lin M.D., Ph.D. |
| author_facet | Tzu-Min Chan Horng-Jyh Harn Hui-Ping Lin Shao-Chih Chiu Po-Cheng Lin Hsin-I Wang Li-Ing Ho Chih-Pin Chuu Tzyy-Wen Chiou An-Cheng Hsieh Yu-Wen Chen Wen-Yu Ho Shinn-Zong Lin M.D., Ph.D. |
| author_sort | Tzu-Min Chan |
| collection | DOAJ |
| description | Stroke is one of the disorders for which clinically effective therapeutic modalities are most needed, and numerous ways have been explored to attempt to investigate their feasibilities. However, ischemic- or hemorrhagicinduced inflammatory neuron death causes irreversible injuries and infarction regions, and there are currently no truly effective drugs available as therapy. It is therefore urgent to be able to provide a fundamental treatment method to regenerate neuronal brain cells, and therefore, the use of stem cells for curing chronic stroke could be a major breakthrough development. In this review, we describe the features and classification of stroke and focus on the benefits of adipose tissue-derived stem cells and their applications in stroke animal models. The results show that cell-based therapies have resulted in significant improvements in neuronal behaviors and functions through different molecular mechanisms, and no safety problems have so far arisen after transplantation. Further, we propose a clinical possibility to create a homing niche by reducing the degree of invasive intracerebroventricular transplantation and combining it with continuous intravenous administration to achieve a complete cure. |
| first_indexed | 2024-12-13T08:35:01Z |
| format | Article |
| id | doaj.art-945f7d90b28348c889b6f8f62f41fdcf |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-13T08:35:01Z |
| publishDate | 2014-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-945f7d90b28348c889b6f8f62f41fdcf2022-12-21T23:53:39ZengSAGE PublishingCell Transplantation0963-68971555-38922014-05-012310.3727/096368914X678409The Use of ADSCs as a Treatment for Chronic StrokeTzu-Min Chan0Horng-Jyh Harn1Hui-Ping Lin2Shao-Chih Chiu3Po-Cheng Lin4Hsin-I Wang5Li-Ing Ho6Chih-Pin Chuu7Tzyy-Wen Chiou8An-Cheng Hsieh9Yu-Wen Chen10Wen-Yu Ho11Shinn-Zong Lin M.D., Ph.D.12Everfront Biotech Inc., New Taipei City, TaiwanDepartment of Pathology, China Medical University Hospital, Taichung, TaiwanInstitute of Cellular and System Medicine, National Health Research Institutes, Miaoli, TaiwanGraduate Institute of Immunology, China Medical University, Taichung, TaiwanGwoXi Stem Cell Applied Technology, Hsinchu, TaiwanGwoXi Stem Cell Applied Technology, Hsinchu, TaiwanDepartment of Respiratory Therapy, Taipei Veterans General Hospital, Taipei, TaiwanInstitute of Cellular and System Medicine, National Health Research Institutes, Miaoli, TaiwanDepartment of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, TaiwanCenter for Neuropsychiatry, China Medical University Hospital, Taichung, TaiwanCenter for Neuropsychiatry, China Medical University Hospital, Taichung, TaiwanDepartmentof Medical Technology, Nursing and Management, Jen-Teh Junior College of Medicine, TaiwanDepartment of Neurosurgery, Tainan Municipal An-Nan Hospital, China Medical University, Tainan, TaiwanStroke is one of the disorders for which clinically effective therapeutic modalities are most needed, and numerous ways have been explored to attempt to investigate their feasibilities. However, ischemic- or hemorrhagicinduced inflammatory neuron death causes irreversible injuries and infarction regions, and there are currently no truly effective drugs available as therapy. It is therefore urgent to be able to provide a fundamental treatment method to regenerate neuronal brain cells, and therefore, the use of stem cells for curing chronic stroke could be a major breakthrough development. In this review, we describe the features and classification of stroke and focus on the benefits of adipose tissue-derived stem cells and their applications in stroke animal models. The results show that cell-based therapies have resulted in significant improvements in neuronal behaviors and functions through different molecular mechanisms, and no safety problems have so far arisen after transplantation. Further, we propose a clinical possibility to create a homing niche by reducing the degree of invasive intracerebroventricular transplantation and combining it with continuous intravenous administration to achieve a complete cure.https://doi.org/10.3727/096368914X678409 |
| spellingShingle | Tzu-Min Chan Horng-Jyh Harn Hui-Ping Lin Shao-Chih Chiu Po-Cheng Lin Hsin-I Wang Li-Ing Ho Chih-Pin Chuu Tzyy-Wen Chiou An-Cheng Hsieh Yu-Wen Chen Wen-Yu Ho Shinn-Zong Lin M.D., Ph.D. The Use of ADSCs as a Treatment for Chronic Stroke Cell Transplantation |
| title | The Use of ADSCs as a Treatment for Chronic Stroke |
| title_full | The Use of ADSCs as a Treatment for Chronic Stroke |
| title_fullStr | The Use of ADSCs as a Treatment for Chronic Stroke |
| title_full_unstemmed | The Use of ADSCs as a Treatment for Chronic Stroke |
| title_short | The Use of ADSCs as a Treatment for Chronic Stroke |
| title_sort | use of adscs as a treatment for chronic stroke |
| url | https://doi.org/10.3727/096368914X678409 |
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