Liver Injury by the Traditional Chinese Medicine Hanshirento, Zenshikunshito, and Ninjin’yoeito in a Patient with Lung Cancer: Probable Causality Assessed by the Updated Roussel Uclaf Causality Assessment Method
Introduction: Traditional Chinese medicine (TCM) is a traditional treatment based on herbal medicines and holistic healing. It has resulted in both favorable and unfavorable patient outcomes when used to treat cancer. Cancer patients frequently depend on second opinions and folk remedies. In this ca...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-03-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/15347354211004734 |
| _version_ | 1818622392713347072 |
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| author | Haruki Funakoshi BS Kenji Momo PhD Ayaka Kashima MD Hitomi Ida MD, PhD Yoshito Miyata MD, PhD Hironori Sagara MD, PhD Tadanori Sasaki PhD |
| author_facet | Haruki Funakoshi BS Kenji Momo PhD Ayaka Kashima MD Hitomi Ida MD, PhD Yoshito Miyata MD, PhD Hironori Sagara MD, PhD Tadanori Sasaki PhD |
| author_sort | Haruki Funakoshi BS |
| collection | DOAJ |
| description | Introduction: Traditional Chinese medicine (TCM) is a traditional treatment based on herbal medicines and holistic healing. It has resulted in both favorable and unfavorable patient outcomes when used to treat cancer. Cancer patients frequently depend on second opinions and folk remedies. In this case, we report the case of TCM inducing repeated moderate liver injury and delay for chemotherapy. Case presentation: A 59-year-old woman was diagnosed with lung cancer and conducted surgery a month ago. She went to a TCM specialty clinic expecting a complete cure for the lung cancer, to improve her physical condition, and to enhance her immunity. She received the TCM formulas hanshirento, zenshikunshito, and ninjin’yoeito. After starting these medicines, she felt severe fatigue but continued them for approximately 2 weeks, After discontinuing the medicine, her fatigue was improved. She was admitted to our hospital for adjuvant chemotherapy. On admission, laboratory tests revealed moderate liver injury (AST: 705 U/L, ALT: 1091 U/L). In view of her medication history, the laboratory tests, and her lifestyle history, we thought that moderate liver injury was caused by TCM, employing the Roussel Uclaf Causality Assessment Method (RUCAM). Discussion: TCM are known to be metabolized by the resident bacteria in the small intestine, but the specific metabolic processes are not well understood. Cancer patients sometimes try TCM from their own research to stay healthy. However, as with our case, TCM rarely induces liver injury, which is not well known to TCM users. Medical staffs need to be vigilant with their drug histories, including TCM, if patients have liver injuries. |
| first_indexed | 2024-12-16T18:24:27Z |
| format | Article |
| id | doaj.art-945f84aa003a4eb98334a3edfe902359 |
| institution | Directory Open Access Journal |
| issn | 1534-7354 1552-695X |
| language | English |
| last_indexed | 2024-12-16T18:24:27Z |
| publishDate | 2021-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-945f84aa003a4eb98334a3edfe9023592022-12-21T22:21:27ZengSAGE PublishingIntegrative Cancer Therapies1534-73541552-695X2021-03-012010.1177/15347354211004734Liver Injury by the Traditional Chinese Medicine Hanshirento, Zenshikunshito, and Ninjin’yoeito in a Patient with Lung Cancer: Probable Causality Assessed by the Updated Roussel Uclaf Causality Assessment MethodHaruki Funakoshi BS0Kenji Momo PhD1Ayaka Kashima MD2Hitomi Ida MD, PhD3Yoshito Miyata MD, PhD4Hironori Sagara MD, PhD5Tadanori Sasaki PhD6Showa University, Shinagawa-ku, Tokyo, JapanShowa University, Shinagawa-ku, Tokyo, JapanShowa University School of Medicine, Shinagawa-ku, Tokyo, JapanShowa University School of Medicine, Shinagawa-ku, Tokyo, JapanShowa University School of Medicine, Shinagawa-ku, Tokyo, JapanShowa University School of Medicine, Shinagawa-ku, Tokyo, JapanShowa University, Shinagawa-ku, Tokyo, JapanIntroduction: Traditional Chinese medicine (TCM) is a traditional treatment based on herbal medicines and holistic healing. It has resulted in both favorable and unfavorable patient outcomes when used to treat cancer. Cancer patients frequently depend on second opinions and folk remedies. In this case, we report the case of TCM inducing repeated moderate liver injury and delay for chemotherapy. Case presentation: A 59-year-old woman was diagnosed with lung cancer and conducted surgery a month ago. She went to a TCM specialty clinic expecting a complete cure for the lung cancer, to improve her physical condition, and to enhance her immunity. She received the TCM formulas hanshirento, zenshikunshito, and ninjin’yoeito. After starting these medicines, she felt severe fatigue but continued them for approximately 2 weeks, After discontinuing the medicine, her fatigue was improved. She was admitted to our hospital for adjuvant chemotherapy. On admission, laboratory tests revealed moderate liver injury (AST: 705 U/L, ALT: 1091 U/L). In view of her medication history, the laboratory tests, and her lifestyle history, we thought that moderate liver injury was caused by TCM, employing the Roussel Uclaf Causality Assessment Method (RUCAM). Discussion: TCM are known to be metabolized by the resident bacteria in the small intestine, but the specific metabolic processes are not well understood. Cancer patients sometimes try TCM from their own research to stay healthy. However, as with our case, TCM rarely induces liver injury, which is not well known to TCM users. Medical staffs need to be vigilant with their drug histories, including TCM, if patients have liver injuries.https://doi.org/10.1177/15347354211004734 |
| spellingShingle | Haruki Funakoshi BS Kenji Momo PhD Ayaka Kashima MD Hitomi Ida MD, PhD Yoshito Miyata MD, PhD Hironori Sagara MD, PhD Tadanori Sasaki PhD Liver Injury by the Traditional Chinese Medicine Hanshirento, Zenshikunshito, and Ninjin’yoeito in a Patient with Lung Cancer: Probable Causality Assessed by the Updated Roussel Uclaf Causality Assessment Method Integrative Cancer Therapies |
| title | Liver Injury by the Traditional Chinese Medicine Hanshirento, Zenshikunshito, and Ninjin’yoeito in a Patient with Lung Cancer: Probable Causality Assessed by the Updated Roussel Uclaf Causality Assessment Method |
| title_full | Liver Injury by the Traditional Chinese Medicine Hanshirento, Zenshikunshito, and Ninjin’yoeito in a Patient with Lung Cancer: Probable Causality Assessed by the Updated Roussel Uclaf Causality Assessment Method |
| title_fullStr | Liver Injury by the Traditional Chinese Medicine Hanshirento, Zenshikunshito, and Ninjin’yoeito in a Patient with Lung Cancer: Probable Causality Assessed by the Updated Roussel Uclaf Causality Assessment Method |
| title_full_unstemmed | Liver Injury by the Traditional Chinese Medicine Hanshirento, Zenshikunshito, and Ninjin’yoeito in a Patient with Lung Cancer: Probable Causality Assessed by the Updated Roussel Uclaf Causality Assessment Method |
| title_short | Liver Injury by the Traditional Chinese Medicine Hanshirento, Zenshikunshito, and Ninjin’yoeito in a Patient with Lung Cancer: Probable Causality Assessed by the Updated Roussel Uclaf Causality Assessment Method |
| title_sort | liver injury by the traditional chinese medicine hanshirento zenshikunshito and ninjin yoeito in a patient with lung cancer probable causality assessed by the updated roussel uclaf causality assessment method |
| url | https://doi.org/10.1177/15347354211004734 |
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