Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer
The importance of mitochondria is not only limited to energy generation but also in several physical and chemical processes critical for cell survival. Mitochondria play an essential role in cellular apoptosis, calcium ion transport and cellular metabolism. Mutation in the nuclear and mitochondrial...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223001865 |
| _version_ | 1797894746553712640 |
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| author | Soumi Mukherjee Gurjit Kaur Bhatti Ravindresh Chhabra P. Hemachandra Reddy Jasvinder Singh Bhatti |
| author_facet | Soumi Mukherjee Gurjit Kaur Bhatti Ravindresh Chhabra P. Hemachandra Reddy Jasvinder Singh Bhatti |
| author_sort | Soumi Mukherjee |
| collection | DOAJ |
| description | The importance of mitochondria is not only limited to energy generation but also in several physical and chemical processes critical for cell survival. Mitochondria play an essential role in cellular apoptosis, calcium ion transport and cellular metabolism. Mutation in the nuclear and mitochondrial genes, altered oncogenes/tumor suppressor genes, and deregulated signalling for cell viability are major reasons for cancer progression and chemoresistance. The development of drug resistance in cancer patients is a major challenge in cancer treatment as the resistant cells are often more aggressive. The drug resistant cells of numerous cancer types exhibit the deregulation of mitochondrial function. The increased biogenesis of mitochondria and its dynamic alteration contribute to developing resistance. Further, a small subpopulation of cancer stem cells in the heterogeneous tumor is primarily responsible for chemoresistance and has an attribute of mitochondrial dysfunction. This review highlights the critical role of mitochondrial dysfunction in chemoresistance in cancer cells through the processes of apoptosis, autophagy/mitophagy, and cancer stemness. Mitochondria-targeted therapeutic strategies might help reduce cancer progression and chemoresistance induced by various cancer drugs. |
| first_indexed | 2024-04-10T07:14:14Z |
| format | Article |
| id | doaj.art-945f8a549d05449ca5ec44819df161ef |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-10T07:14:14Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-945f8a549d05449ca5ec44819df161ef2023-02-26T04:26:43ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-04-01160114398Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancerSoumi Mukherjee0Gurjit Kaur Bhatti1Ravindresh Chhabra2P. Hemachandra Reddy3Jasvinder Singh Bhatti4Laboratory of Translational Medicine and Nanotherapeutics, Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Bathinda, IndiaDepartment of Medical Lab Technology, University Institute of Applied Health Sciences, Chandigarh University, Mohali, IndiaDepartment of Biochemistry, School of Basic Sciences, Central University of Punjab, Bathinda, IndiaDepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Pharmacology and Neuroscience and Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Public Health, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Speech, Language, and Hearing Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Correspondence to: Internal Medicine, Neuroscience & Pharmacology, Neurology, Public Health and School of Health Professions, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA.Laboratory of Translational Medicine and Nanotherapeutics, Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Bathinda, India; Correspondence to: Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Bathinda, India.The importance of mitochondria is not only limited to energy generation but also in several physical and chemical processes critical for cell survival. Mitochondria play an essential role in cellular apoptosis, calcium ion transport and cellular metabolism. Mutation in the nuclear and mitochondrial genes, altered oncogenes/tumor suppressor genes, and deregulated signalling for cell viability are major reasons for cancer progression and chemoresistance. The development of drug resistance in cancer patients is a major challenge in cancer treatment as the resistant cells are often more aggressive. The drug resistant cells of numerous cancer types exhibit the deregulation of mitochondrial function. The increased biogenesis of mitochondria and its dynamic alteration contribute to developing resistance. Further, a small subpopulation of cancer stem cells in the heterogeneous tumor is primarily responsible for chemoresistance and has an attribute of mitochondrial dysfunction. This review highlights the critical role of mitochondrial dysfunction in chemoresistance in cancer cells through the processes of apoptosis, autophagy/mitophagy, and cancer stemness. Mitochondria-targeted therapeutic strategies might help reduce cancer progression and chemoresistance induced by various cancer drugs.http://www.sciencedirect.com/science/article/pii/S0753332223001865Cancer chemoresistanceMitochondrial dysfunctionApoptosis, AutophagyMitochondrial dynamicsMitochondrial biogenesis, Stemness |
| spellingShingle | Soumi Mukherjee Gurjit Kaur Bhatti Ravindresh Chhabra P. Hemachandra Reddy Jasvinder Singh Bhatti Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer Biomedicine & Pharmacotherapy Cancer chemoresistance Mitochondrial dysfunction Apoptosis, Autophagy Mitochondrial dynamics Mitochondrial biogenesis, Stemness |
| title | Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer |
| title_full | Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer |
| title_fullStr | Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer |
| title_full_unstemmed | Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer |
| title_short | Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer |
| title_sort | targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer |
| topic | Cancer chemoresistance Mitochondrial dysfunction Apoptosis, Autophagy Mitochondrial dynamics Mitochondrial biogenesis, Stemness |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223001865 |
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