Microwave-Assisted Sequential One-Pot Synthesis of 8-Substituted Pyrazolo[1,5-<i>a</i>][1,3,5]triazines
This paper reports a convenient sequential one-pot approach for the synthesis of an array of 14 pyrazolo[1,5-<i>a</i>][1,3,5]triazines, substituted in C8 by halogen (Br), various functions (CN and CO<sub>2</sub>Et) and alkyl or (het)aryl groups. This study confirms the intere...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/12/3540 |
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| author | Jonathan Elie Corinne Fruit Thierry Besson |
| author_facet | Jonathan Elie Corinne Fruit Thierry Besson |
| author_sort | Jonathan Elie |
| collection | DOAJ |
| description | This paper reports a convenient sequential one-pot approach for the synthesis of an array of 14 pyrazolo[1,5-<i>a</i>][1,3,5]triazines, substituted in C8 by halogen (Br), various functions (CN and CO<sub>2</sub>Et) and alkyl or (het)aryl groups. This study confirms the interest of combining the efficient heating obtained under dielectric microwave heating and the achievement of sequential one-pot reactions, avoiding the tedious work-up and purification of intermediate compounds, achieving sustainable synthesis processes. Considering usual conventional methods, this microwave protocol is featured by advantages in terms of yields, reaction times, and convenient gram scale synthesis. |
| first_indexed | 2024-03-10T10:32:24Z |
| format | Article |
| id | doaj.art-946041da85e945e48f5d8fc6114f67cc |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:32:24Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-946041da85e945e48f5d8fc6114f67cc2023-11-21T23:31:51ZengMDPI AGMolecules1420-30492021-06-012612354010.3390/molecules26123540Microwave-Assisted Sequential One-Pot Synthesis of 8-Substituted Pyrazolo[1,5-<i>a</i>][1,3,5]triazinesJonathan Elie0Corinne Fruit1Thierry Besson2Perha Pharmaceuticals, Perharidy Peninsula, 29680 Roscoff, FrancePerha Pharmaceuticals, Perharidy Peninsula, 29680 Roscoff, FrancePerha Pharmaceuticals, Perharidy Peninsula, 29680 Roscoff, FranceThis paper reports a convenient sequential one-pot approach for the synthesis of an array of 14 pyrazolo[1,5-<i>a</i>][1,3,5]triazines, substituted in C8 by halogen (Br), various functions (CN and CO<sub>2</sub>Et) and alkyl or (het)aryl groups. This study confirms the interest of combining the efficient heating obtained under dielectric microwave heating and the achievement of sequential one-pot reactions, avoiding the tedious work-up and purification of intermediate compounds, achieving sustainable synthesis processes. Considering usual conventional methods, this microwave protocol is featured by advantages in terms of yields, reaction times, and convenient gram scale synthesis.https://www.mdpi.com/1420-3049/26/12/3540microwave-assisted chemistryone-pot synthesispyrazolo[1,5-<i>a</i>][1,3,5]triazines5-aza-9-deazapurines |
| spellingShingle | Jonathan Elie Corinne Fruit Thierry Besson Microwave-Assisted Sequential One-Pot Synthesis of 8-Substituted Pyrazolo[1,5-<i>a</i>][1,3,5]triazines Molecules microwave-assisted chemistry one-pot synthesis pyrazolo[1,5-<i>a</i>][1,3,5]triazines 5-aza-9-deazapurines |
| title | Microwave-Assisted Sequential One-Pot Synthesis of 8-Substituted Pyrazolo[1,5-<i>a</i>][1,3,5]triazines |
| title_full | Microwave-Assisted Sequential One-Pot Synthesis of 8-Substituted Pyrazolo[1,5-<i>a</i>][1,3,5]triazines |
| title_fullStr | Microwave-Assisted Sequential One-Pot Synthesis of 8-Substituted Pyrazolo[1,5-<i>a</i>][1,3,5]triazines |
| title_full_unstemmed | Microwave-Assisted Sequential One-Pot Synthesis of 8-Substituted Pyrazolo[1,5-<i>a</i>][1,3,5]triazines |
| title_short | Microwave-Assisted Sequential One-Pot Synthesis of 8-Substituted Pyrazolo[1,5-<i>a</i>][1,3,5]triazines |
| title_sort | microwave assisted sequential one pot synthesis of 8 substituted pyrazolo 1 5 i a i 1 3 5 triazines |
| topic | microwave-assisted chemistry one-pot synthesis pyrazolo[1,5-<i>a</i>][1,3,5]triazines 5-aza-9-deazapurines |
| url | https://www.mdpi.com/1420-3049/26/12/3540 |
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