Fecal microbiota transplantation treatment of autoimmune-mediated type 1 diabetes: A systematic review

There is a strong link between fecal microbiota and the development of type 1 diabetes. As an emerging therapeutic modality, fecal microbiota transplantation has been shown to be safe and effective in the treatment of many intestinal and extraintestinal diseases. Various studies have found that feca...

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Detalhes bibliográficos
Principais autores: Shuo Zhang, Feiying Deng, Jingxian Chen, Fengwu Chen, Zezhen Wu, Liping Li, Kaijian Hou
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2022-12-01
coleção:Frontiers in Cellular and Infection Microbiology
Assuntos:
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcimb.2022.1075201/full
Descrição
Resumo:There is a strong link between fecal microbiota and the development of type 1 diabetes. As an emerging therapeutic modality, fecal microbiota transplantation has been shown to be safe and effective in the treatment of many intestinal and extraintestinal diseases. Various studies have found that fecal microbiota transplantation can treat diseases by correcting patients’ immune disorders. Besides, many studies have found that fecal microbiota transplantation can improve glycemic control and insulin resistance in diabetic patients. Therefore, this paper reviews the mechanism of action of fecal microbiota transplantation on autoimmune-mediated T1DM and the current research progress, feasibility, and issues that need to be addressed in the future development of fecal microbiota transplantation in the treatment of autoimmune-mediated T1DM.
ISSN:2235-2988