Evaluation of Efflux-Mediated Resistance and Biofilm formation in Virulent <i>Pseudomonas aeruginosa</i> Associated with Healthcare Infections

Evaluation of Efflux-Mediated Resistance and Biofilm formation in Virulent <i>Pseudomonas aeruginosa</i> Associated with Healthcare Infections

<i>Pseudomonas aeruginosa</i> is a significant pathogen identified with healthcare-associated infections. The present study evaluates the role of biofilm and efflux pump activities in influencing high-level resistance in virulent <i>P. aeruginosa</i> strains in clinical infec...

Full description

Bibliographic Details
Main Authors:	Paul A. Akinduti, Onome W. George, Hannah U. Ohore, Olusegun E. Ariyo, Samuel T. Popoola, Adenike I. Adeleye, Kazeem S. Akinwande, Jacob O. Popoola, Solomon O. Rotimi, Fredrick O. Olufemi, Conrad A. Omonhinmin, Grace I. Olasehinde
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Series:	Antibiotics
Subjects:	<i>Pseudomonas aeruginosa</i> antibiotic resistance biofilm efflux pump virulence factors
Online Access:	https://www.mdpi.com/2079-6382/12/3/626

Similar Items

Role of Efflux Pumps on Antimicrobial Resistance in <i>Pseudomonas aeruginosa</i>
by: Andre Bittencourt Lorusso, et al.
Published: (2022-12-01)

The Contribution of Efflux Pumps in <i>Mycobacterium abscessus</i> Complex Resistance to Clarithromycin
by: Júlia S. Vianna, et al.
Published: (2019-09-01)

Evaluation of Heterocyclic Carboxamides as Potential Efflux Pump Inhibitors in <i>Pseudomonas aeruginosa</i>
by: Yi Yuan, et al.
Published: (2021-12-01)

Role of PatAB Transporter in Efflux of Levofloxacin in <i>Streptococcus pneumoniae</i>
by: Mónica Amblar, et al.
Published: (2022-12-01)

Contribution of RND-Type Efflux Pumps in Reduced Susceptibility to Biocides in <i>Acinetobacter baumannii</i>
by: Christina Meyer, et al.
Published: (2022-11-01)

Types and Mechanisms of Efflux Pump Systems and the Potential of Efflux Pump Inhibitors in the Restoration of Antimicrobial Susceptibility, with a Special Reference to <i>Acinetobacter baumannii</i>
by: Kira M. Zack, et al.
Published: (2024-02-01)

Evaluation of a Conformationally Constrained Indole Carboxamide as a Potential Efflux Pump Inhibitor in <i>Pseudomonas</i> <i>aeruginosa</i>
by: Yongzheng Zhang, et al.
Published: (2022-05-01)

MexAB-OprM Efflux Pump Interaction with the Peptidoglycan of <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i>
by: Miao Ma, et al.
Published: (2021-05-01)

Efflux <i>MexAB</i>-Mediated Resistance in <i>P. aeruginosa</i> Isolated from Patients with Healthcare Associated Infections
by: Rania M. Kishk, et al.
Published: (2020-06-01)

RND Efflux Systems Contribute to Resistance and Virulence of <i>Aliarcobacter butzleri</i>
by: Cristiana Mateus, et al.
Published: (2021-07-01)

AgNPs Targeting the Drug Resistance Problem of <i>Staphylococcus aureus</i>: Susceptibility to Antibiotics and Efflux Effect
by: Ekaterina Nefedova, et al.
Published: (2022-03-01)

Chalcones Isolated from <i>Arrabidaea brachypoda</i> Flowers as Inhibitors of NorA and MepA Multidrug Efflux Pumps of <i>Staphylococcus aureus</i>
by: Luís Mário Rezende-Júnior, et al.
Published: (2020-06-01)

Overexpression of the MexXY Multidrug Efflux System Correlates with Deficient Pyoverdine Production in <i>Pseudomonas aeruginosa</i>
by: Kei Ikarashi, et al.
Published: (2021-05-01)

<i>Pseudomonas aeruginosa</i> <i>mexR</i> and <i>mexEF</i> Antibiotic Efflux Pump Variants Exhibit Increased Virulence
by: Mylene Vaillancourt, et al.
Published: (2021-09-01)

The Impact of an Efflux Pump Inhibitor on the Activity of Free and Liposomal Antibiotics against <i>Pseudomonas aeruginosa</i>
by: Douweh Leyla Gbian, et al.
Published: (2021-04-01)

Genetic Determinants of <i>Acinetobacter baumannii</i> Serum-Associated Adaptive Efflux-Mediated Antibiotic Resistance
by: Mikaeel Young, et al.
Published: (2023-07-01)

Spermidine Binding to the <i>Acetinobacter baumannii</i> Efflux Protein AceI Observed by Near-UV Synchrotron Radiation Circular Dichroism Spectroscopy
by: Simon G. Patching
Published: (2022-05-01)

Occurrence and Variability of the Efflux Pump Gene <i>norA</i> across the <i>Staphylococcus</i> Genus
by: Carolina Ferreira, et al.
Published: (2022-12-01)

Identification of Efflux Pump Mutations in <i>Pseudomonas aeruginosa</i> from Clinical Samples
by: Sonia Quddus, et al.
Published: (2023-03-01)

Resveratrol as an Inhibitor of the NorA Efflux Pump and Resistance Modulator in <i>Staphylococcus aureus</i>
by: Madalena Santos, et al.
Published: (2023-07-01)

Motility, Biofilm Formation and Antimicrobial Efflux of Sessile and Planktonic Cells of <i>Achromobacter xylosoxidans</i>
by: Signe M. Nielsen, et al.
Published: (2019-01-01)

Inhibition of <i>Staphylococcus pseudintermedius</i> Efflux Pumps by Using <i>Staphylococcus aureus</i> NorA Efflux Pump Inhibitors
by: Elisa Rampacci, et al.
Published: (2023-04-01)

Penetration through Outer Membrane and Efflux Potential in <i>Pseudomonas aeruginosa</i> of Bulgecin A as an Adjuvant to β-Lactam Antibiotics
by: Choon Kim, et al.
Published: (2023-02-01)

<i>Acinetobacter baumannii</i> Survival under Infection-Associated Stresses Depends on the Expression of Resistance–Nodulation–Division and Major Facilitator Superfamily Efflux Pumps
by: Inga V. Leus, et al.
Published: (2023-12-01)

Role of Efflux Pump-Mediated Antibiotic Resistance in Quorum Sensing-Regulated Biofilm Formation by <i>Salmonella</i> Typhimurium
by: Jirapat Dawan, et al.
Published: (2022-01-01)

Putative Role of an ABC Efflux System in <i>Aliarcobacter butzleri</i> Resistance and Virulence
by: Inês Martins, et al.
Published: (2023-02-01)

Exploring Efflux as a Mechanism of Reduced Susceptibility towards Biocides and Fluoroquinolones in <i>Staphylococcus pseudintermedius</i>
by: Marta Leal, et al.
Published: (2023-04-01)

Phenylpiperazine 5,5-Dimethylhydantoin Derivatives as First Synthetic Inhibitors of Msr(A) Efflux Pump in <i>Staphylococcus epidermidis</i>
by: Karolina Witek, et al.
Published: (2020-08-01)

Photodynamic Inactivation Effectively Eradicates <i>Candida auris</i> Biofilm despite Its Interference with the Upregulation of <i>CDR1</i> and <i>MDR1</i> Efflux Genes
by: Matúš Štefánek, et al.
Published: (2022-10-01)

Efflux Pump Inhibition and Resistance Modulation in <i>Mycobacterium smegmatis</i> by <i>Peucedanum ostruthium</i> and Its Coumarins
by: Katarina Šimunović, et al.
Published: (2021-09-01)

Differential Gene Expression of Efflux Pumps and Porins in Clinical Isolates of MDR <i>Acinetobacter baumannii</i>
by: Khalid I. AlQumaizi, et al.
Published: (2022-03-01)

<i>Camellia sinensis</i> Chloroplast Fluoride Efflux Gene <i>CsABCB9</i> Is Involved in the Fluoride Tolerance Mechanism
by: Bingbing Luo, et al.
Published: (2022-07-01)

Efflux Pumps and Different Genetic Contexts of <i>tet</i>(X4) Contribute to High Tigecycline Resistance in <i>Escherichia fergusonii</i> from Pigs
by: Junlin Wang, et al.
Published: (2023-04-01)

The Art of War with <i>Pseudomonas aeruginosa</i>: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy
by: Asiyeh Avakh, et al.
Published: (2023-08-01)

Role of the MDR Efflux Pump AcrAB in Epithelial Cell Invasion by <i>Shigella flexneri</i>
by: Marco Coluccia, et al.
Published: (2023-05-01)

Antibacterial Effect of 16 Essential Oils and Modulation of <i>mex</i> Efflux Pumps Gene Expression on Multidrug-Resistant <i>Pseudomonas aeruginosa</i> Clinical Isolates: Is Cinnamon a Good Fighter?
by: Răzvan Lucian Coșeriu, et al.
Published: (2023-01-01)

Genomic and Metabolic Insights into Denitrification, Sulfur Oxidation, and Multidrug Efflux Pump Mechanisms in the Bacterium <i>Rhodoferax sediminis</i> sp. nov.
by: Chun-Zhi Jin, et al.
Published: (2020-02-01)

Antibacterial and Anti-Efflux Activities of Cinnamon Essential Oil against Pan and Extensive Drug-Resistant <i>Pseudomonas aeruginosa</i> Isolated from Human and Animal Sources
by: Mohamed A. I. Abdelatti, et al.
Published: (2023-10-01)

AIBP and APOA-I synergistically inhibit intestinal tumor growth and metastasis by promoting cholesterol efflux
by: Tao Zhang, et al.
Published: (2019-05-01)

Association of Antibacterial Susceptibility Profile with the Prevalence of Genes Encoding Efflux Proteins in the Bangladeshi Clinical Isolates of <i>Staphylococcus aureus</i>
by: Tanjina Akter Suma, et al.
Published: (2023-02-01)