Investigation of Binding Modes and Functional Surface of Scorpion Toxins ANEP to Sodium Channels 1.7

Investigation of Binding Modes and Functional Surface of Scorpion Toxins ANEP to Sodium Channels 1.7

The depressant β toxin anti-neuroexcitation peptide (ANEP) from the Chinese scorpion Buthus martensii Karsch has analgesic activity by interacting with receptor site 4 of the voltage-gated sodium channels (VGSCs). Here, with molecular dynamics simulations, we examined the binding modes between ANEP...

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Bibliographic Details
Main Authors: Yongbo Song, Zeyu Liu, Qi Zhang, Chunming Li, Wei Jin, Lili Liu, Jianye Zhang, Jinghai Zhang
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Toxins
Subjects:
Buthus martensii Karsch
analgesic activity
ANEP
Nav1.7-site 4
molecular dynamics simulations
Online Access:https://www.mdpi.com/2072-6651/9/12/387

Internet

https://www.mdpi.com/2072-6651/9/12/387

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