Tubeimoside I Inhibits Cell Proliferation and Induces a Partly Disrupted and Cytoprotective Autophagy Through Rapidly Hyperactivation of MEK1/2-ERK1/2 Cascade via Promoting PTP1B in Melanoma

Tubeimoside I Inhibits Cell Proliferation and Induces a Partly Disrupted and Cytoprotective Autophagy Through Rapidly Hyperactivation of MEK1/2-ERK1/2 Cascade via Promoting PTP1B in Melanoma

Tubeimoside I (TBMS1), also referred to as tubeimoside A, is a natural compound extracted from the plant Tu Bei Mu (Bolbostemma paniculatum), which is a traditional Chinese herb used to treat multiple diseases for more than 1,000 years. Studies in recent years reported its anti-tumor activity in sev...

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Bibliographic Details
Main Authors: Juan Du, Zhen Dong, Li Tan, Mengqin Tan, Fang Zhang, Kui Zhang, Guangzhao Pan, Chongyang Li, Shaomin Shi, Yanli Zhang, Yaling Liu, Hongjuan Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
tubeimoside-1
melanoma
MEK1/2-ERK1/2 cascade
autophagy
PTP1B
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.607757/full

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