Burden, risk factors, and management of neutropenic fever among solid cancer patients in Ethiopia
Objectives: Although neutropenic fever is one of the most well-known oncologic emergencies and the common causes of death, a few studies have been conducted in resource-limited countries, particularly in Ethiopia. This study aimed to assess the burden, risk factors, and management of neutropenic fev...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-05-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121221098236 |
| _version_ | 1811335691111497728 |
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| author | Samuel Agegnew Wondm Ephrem Mebratu Dagnew Sumeya Tadesse Abegaz Mekdes Kiflu Bekalu Kebede |
| author_facet | Samuel Agegnew Wondm Ephrem Mebratu Dagnew Sumeya Tadesse Abegaz Mekdes Kiflu Bekalu Kebede |
| author_sort | Samuel Agegnew Wondm |
| collection | DOAJ |
| description | Objectives: Although neutropenic fever is one of the most well-known oncologic emergencies and the common causes of death, a few studies have been conducted in resource-limited countries, particularly in Ethiopia. This study aimed to assess the burden, risk factors, and management of neutropenic fever among solid cancer patients in Ethiopia. Methods: A hospital-based retrospective follow-up study was conducted from January 2017 to February 2021. Data were collected from patient’s medical charts using a structured data abstraction format and analyzed using STATA version 14.2. Logistic regression analyses were used to identify independent predictors of neutropenic fever, and a p -value of < 0.05 was considered statistically significant. Results: A total of 416 patients were included, with a mean age of 51 ± 14 years. The cumulative incidence of neutropenic fever was 13%. Advanced age, low baseline white blood cell, prolonged duration of neutropenia, and presence of two or more comorbidities were factors significantly associated with neutropenic fever ( p < 0.05). Among patients who need primary prophylaxis, 68% of patients did not get appropriate primary prophylaxis, and 30%, 71%, and 93% of prescribed anti-bacterial, anti-fungal, and anti-viral agents were inappropriate according to Infectious Disease Society of America Guideline, respectively. Conclusion: Neutropenic fever was common among solid cancer patients and it is multifactorial. The rate of guideline adherence during prophylaxis and treatment of neutropenic fever was poor. Health care professionals should be aware of these risk factors, and greater effort is needed to reduce the risk of neutropenic fever. |
| first_indexed | 2024-04-13T17:28:01Z |
| format | Article |
| id | doaj.art-946366010f3a4a998e6c8a8102b7440f |
| institution | Directory Open Access Journal |
| issn | 2050-3121 |
| language | English |
| last_indexed | 2024-04-13T17:28:01Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj.art-946366010f3a4a998e6c8a8102b7440f2022-12-22T02:37:41ZengSAGE PublishingSAGE Open Medicine2050-31212022-05-011010.1177/20503121221098236Burden, risk factors, and management of neutropenic fever among solid cancer patients in EthiopiaSamuel Agegnew Wondm0Ephrem Mebratu Dagnew1Sumeya Tadesse Abegaz2Mekdes Kiflu3Bekalu Kebede4Clinical Pharmacy Unit, Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaClinical Pharmacy Unit, Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaClinical Pharmacy Department, School of Pharmacy, College of Medicine and Health Science, University of Gondar, Gondar, EthiopiaClinical Pharmacy Unit, Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaClinical Pharmacy Unit, Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaObjectives: Although neutropenic fever is one of the most well-known oncologic emergencies and the common causes of death, a few studies have been conducted in resource-limited countries, particularly in Ethiopia. This study aimed to assess the burden, risk factors, and management of neutropenic fever among solid cancer patients in Ethiopia. Methods: A hospital-based retrospective follow-up study was conducted from January 2017 to February 2021. Data were collected from patient’s medical charts using a structured data abstraction format and analyzed using STATA version 14.2. Logistic regression analyses were used to identify independent predictors of neutropenic fever, and a p -value of < 0.05 was considered statistically significant. Results: A total of 416 patients were included, with a mean age of 51 ± 14 years. The cumulative incidence of neutropenic fever was 13%. Advanced age, low baseline white blood cell, prolonged duration of neutropenia, and presence of two or more comorbidities were factors significantly associated with neutropenic fever ( p < 0.05). Among patients who need primary prophylaxis, 68% of patients did not get appropriate primary prophylaxis, and 30%, 71%, and 93% of prescribed anti-bacterial, anti-fungal, and anti-viral agents were inappropriate according to Infectious Disease Society of America Guideline, respectively. Conclusion: Neutropenic fever was common among solid cancer patients and it is multifactorial. The rate of guideline adherence during prophylaxis and treatment of neutropenic fever was poor. Health care professionals should be aware of these risk factors, and greater effort is needed to reduce the risk of neutropenic fever.https://doi.org/10.1177/20503121221098236 |
| spellingShingle | Samuel Agegnew Wondm Ephrem Mebratu Dagnew Sumeya Tadesse Abegaz Mekdes Kiflu Bekalu Kebede Burden, risk factors, and management of neutropenic fever among solid cancer patients in Ethiopia SAGE Open Medicine |
| title | Burden, risk factors, and management of neutropenic fever among solid cancer patients in Ethiopia |
| title_full | Burden, risk factors, and management of neutropenic fever among solid cancer patients in Ethiopia |
| title_fullStr | Burden, risk factors, and management of neutropenic fever among solid cancer patients in Ethiopia |
| title_full_unstemmed | Burden, risk factors, and management of neutropenic fever among solid cancer patients in Ethiopia |
| title_short | Burden, risk factors, and management of neutropenic fever among solid cancer patients in Ethiopia |
| title_sort | burden risk factors and management of neutropenic fever among solid cancer patients in ethiopia |
| url | https://doi.org/10.1177/20503121221098236 |
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