Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene

Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene

Abstract The genomic effects of circulating glucocorticoids are particularly relevant in cortico-limbic structures, which express a high concentration of steroid hormone receptors. To date, no studies have investigated genomic differences in hippocampal subregions, namely the dorsal (dHPC) and ventr...

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Bibliographic Details
Main Authors: Salvatore G. Caradonna, Nathan R. Einhorn, Vikram Saudagar, Huzefa Khalil, Gordon H. Petty, Axel Lihagen, Claire LeFloch, Francis S. Lee, Huda Akil, Alessandro Guidotti, Bruce S. McEwen, Eleonora Gatta, Jordan Marrocco
Format: Article
Language:English
Published: Nature Publishing Group 2022-03-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-022-01864-7

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