NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation
Germline mono-allelic loss of the tumour suppressor NF1 predisposes patients to the development of benign lesions but rarely further progression into cancer development. Here the authors use mouse models to show that an NF1 heterozygous microenvironment accelerates the formation of benign tumours bu...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07452-y |
| _version_ | 1818681772290867200 |
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| author | Jean-Philippe Brosseau Chung-Ping Liao Yong Wang Vijay Ramani Travis Vandergriff Michelle Lee Amisha Patel Kiyoshi Ariizumi Lu Q. Le |
| author_facet | Jean-Philippe Brosseau Chung-Ping Liao Yong Wang Vijay Ramani Travis Vandergriff Michelle Lee Amisha Patel Kiyoshi Ariizumi Lu Q. Le |
| author_sort | Jean-Philippe Brosseau |
| collection | DOAJ |
| description | Germline mono-allelic loss of the tumour suppressor NF1 predisposes patients to the development of benign lesions but rarely further progression into cancer development. Here the authors use mouse models to show that an NF1 heterozygous microenvironment accelerates the formation of benign tumours but impairs progression to malignancy. |
| first_indexed | 2024-12-17T10:08:15Z |
| format | Article |
| id | doaj.art-9469062130ae408ba5616d707d78a78d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:08:15Z |
| publishDate | 2018-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9469062130ae408ba5616d707d78a78d2022-12-21T21:53:06ZengNature PortfolioNature Communications2041-17232018-11-019111110.1038/s41467-018-07452-yNF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformationJean-Philippe Brosseau0Chung-Ping Liao1Yong Wang2Vijay Ramani3Travis Vandergriff4Michelle Lee5Amisha Patel6Kiyoshi Ariizumi7Lu Q. Le8Department of Dermatology, University of Texas Southwestern Medical CenterDepartment of Dermatology, University of Texas Southwestern Medical CenterDepartment of Dermatology, University of Texas Southwestern Medical CenterDepartment of Dermatology, University of Texas Southwestern Medical CenterDepartment of Dermatology, University of Texas Southwestern Medical CenterDepartment of Dermatology, University of Texas Southwestern Medical CenterDepartment of Dermatology, University of Texas Southwestern Medical CenterDepartment of Dermatology, University of Texas Southwestern Medical CenterDepartment of Dermatology, University of Texas Southwestern Medical CenterGermline mono-allelic loss of the tumour suppressor NF1 predisposes patients to the development of benign lesions but rarely further progression into cancer development. Here the authors use mouse models to show that an NF1 heterozygous microenvironment accelerates the formation of benign tumours but impairs progression to malignancy.https://doi.org/10.1038/s41467-018-07452-y |
| spellingShingle | Jean-Philippe Brosseau Chung-Ping Liao Yong Wang Vijay Ramani Travis Vandergriff Michelle Lee Amisha Patel Kiyoshi Ariizumi Lu Q. Le NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation Nature Communications |
| title | NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation |
| title_full | NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation |
| title_fullStr | NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation |
| title_full_unstemmed | NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation |
| title_short | NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation |
| title_sort | nf1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation |
| url | https://doi.org/10.1038/s41467-018-07452-y |
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