Hypoglycemic therapy in patients with type 2 diabetes and chronic heart failure
The article presents a literature review of prevalence, prognosis and treatment of overt tactics of chronic heart failure (CHF) in patients with type 2 diabetes mellitus (T2DM). Application of modern pharmacological preparations and instrumental treatment of cardiovascular disease (CVD) increases li...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Concilium Medicum
2014-03-01
|
| Series: | КардиоСоматика |
| Subjects: | |
| Online Access: | https://cardiosomatics.orscience.ru/2221-7185/article/view/45071 |
| _version_ | 1818601311707332608 |
|---|---|
| author | S. V Kakorin I. A Averkova A. M Mkrtumyan |
| author_facet | S. V Kakorin I. A Averkova A. M Mkrtumyan |
| author_sort | S. V Kakorin |
| collection | DOAJ |
| description | The article presents a literature review of prevalence, prognosis and treatment of overt tactics of chronic heart failure (CHF) in patients with type 2 diabetes mellitus (T2DM). Application of modern pharmacological preparations and instrumental treatment of cardiovascular disease (CVD) increases life expectancy and improves the quality of life of patients with CHF as with normal carbohydrate metabolism (UO), and with type 2 diabetes. However, the risk of cardiovascular mortality (CAS) in patients with type 2 diabetes, compared to having a normal carbohydrate metabolism remains unchanged.Insulin resistance (IR) and compensatory hyperinsulinemia (GI) play a key role in the pathogenesis of type 2 diabetes. Ongoing research in the twentieth century of coronary heart disease (CHD) and heart failure in patients with type 2 diabetes revealed adverse effects of sulfonylurea medications on the metabolic processes in the myocardium and increased risk of death in patients with severe coronary artery disease. In comparison with sulfonylurea drugs, metformin and insulin not only reduces the risk of cardiovascular disease, but also can prevent or delay the development of type 2 diabetes in individuals with impaired glucose tolerance (IGT) and impaired fasting glucose. Metformin acts on the key link of pathogenesis - insulin resistance, affecting the lower incidence of cardiovascular diseases, the development of chronic disease and mortality compared with insulin and sulfonylurea drugs. However, in patients with chronic heart failure is contraindicated the use of thiazolidinediones and metformin is limited tothe severity of CHF I-II FC NYNA. With effective treatment of chronic heart failure by cardiologists in patients with type 2 diabetes, affecting therapy with insulin resistance should be mandatory. |
| first_indexed | 2024-12-16T12:49:22Z |
| format | Article |
| id | doaj.art-946a3b649c7a42ae9bac74dcce780adc |
| institution | Directory Open Access Journal |
| issn | 2221-7185 2658-5707 |
| language | English |
| last_indexed | 2024-12-16T12:49:22Z |
| publishDate | 2014-03-01 |
| publisher | Concilium Medicum |
| record_format | Article |
| series | КардиоСоматика |
| spelling | doaj.art-946a3b649c7a42ae9bac74dcce780adc2022-12-21T22:31:12ZengConcilium MedicumКардиоСоматика2221-71852658-57072014-03-0151334040737Hypoglycemic therapy in patients with type 2 diabetes and chronic heart failureS. V Kakorin0I. A Averkova1A. M Mkrtumyan2MoscowCity Clinical Hospital №4Evdokimov Moscow State University of Medicine and DentistryEvdokimov Moscow State University of Medicine and DentistryThe article presents a literature review of prevalence, prognosis and treatment of overt tactics of chronic heart failure (CHF) in patients with type 2 diabetes mellitus (T2DM). Application of modern pharmacological preparations and instrumental treatment of cardiovascular disease (CVD) increases life expectancy and improves the quality of life of patients with CHF as with normal carbohydrate metabolism (UO), and with type 2 diabetes. However, the risk of cardiovascular mortality (CAS) in patients with type 2 diabetes, compared to having a normal carbohydrate metabolism remains unchanged.Insulin resistance (IR) and compensatory hyperinsulinemia (GI) play a key role in the pathogenesis of type 2 diabetes. Ongoing research in the twentieth century of coronary heart disease (CHD) and heart failure in patients with type 2 diabetes revealed adverse effects of sulfonylurea medications on the metabolic processes in the myocardium and increased risk of death in patients with severe coronary artery disease. In comparison with sulfonylurea drugs, metformin and insulin not only reduces the risk of cardiovascular disease, but also can prevent or delay the development of type 2 diabetes in individuals with impaired glucose tolerance (IGT) and impaired fasting glucose. Metformin acts on the key link of pathogenesis - insulin resistance, affecting the lower incidence of cardiovascular diseases, the development of chronic disease and mortality compared with insulin and sulfonylurea drugs. However, in patients with chronic heart failure is contraindicated the use of thiazolidinediones and metformin is limited tothe severity of CHF I-II FC NYNA. With effective treatment of chronic heart failure by cardiologists in patients with type 2 diabetes, affecting therapy with insulin resistance should be mandatory.https://cardiosomatics.orscience.ru/2221-7185/article/view/45071type 2 diabeteschronic heart failure (chf)cardiovascular mortalityhyperglycemiaglycated hemoglobininsulin resistance (ir)hyperinsulinemiametforminsulfonylurea medicationsinsulin |
| spellingShingle | S. V Kakorin I. A Averkova A. M Mkrtumyan Hypoglycemic therapy in patients with type 2 diabetes and chronic heart failure КардиоСоматика type 2 diabetes chronic heart failure (chf) cardiovascular mortality hyperglycemia glycated hemoglobin insulin resistance (ir) hyperinsulinemia metformin sulfonylurea medications insulin |
| title | Hypoglycemic therapy in patients with type 2 diabetes and chronic heart failure |
| title_full | Hypoglycemic therapy in patients with type 2 diabetes and chronic heart failure |
| title_fullStr | Hypoglycemic therapy in patients with type 2 diabetes and chronic heart failure |
| title_full_unstemmed | Hypoglycemic therapy in patients with type 2 diabetes and chronic heart failure |
| title_short | Hypoglycemic therapy in patients with type 2 diabetes and chronic heart failure |
| title_sort | hypoglycemic therapy in patients with type 2 diabetes and chronic heart failure |
| topic | type 2 diabetes chronic heart failure (chf) cardiovascular mortality hyperglycemia glycated hemoglobin insulin resistance (ir) hyperinsulinemia metformin sulfonylurea medications insulin |
| url | https://cardiosomatics.orscience.ru/2221-7185/article/view/45071 |
| work_keys_str_mv | AT svkakorin hypoglycemictherapyinpatientswithtype2diabetesandchronicheartfailure AT iaaverkova hypoglycemictherapyinpatientswithtype2diabetesandchronicheartfailure AT ammkrtumyan hypoglycemictherapyinpatientswithtype2diabetesandchronicheartfailure |