Application of Enzymes in Regioselective and Stereoselective Organic Reactions

Nowadays, biocatalysts have received much more attention in chemistry regarding their potential to enable high efficiency, high yield, and eco-friendly processes for a myriad of applications. Nature’s vast repository of catalysts has inspired synthetic chemists. Furthermore, the revolutionary techno...

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Main Authors: Ruipu Mu, Zhaoshuai Wang, Max C. Wamsley, Colbee N. Duke, Payton H. Lii, Sarah E. Epley, London C. Todd, Patty J. Roberts
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Catalysts
Subjects:
Online Access:https://www.mdpi.com/2073-4344/10/8/832
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author Ruipu Mu
Zhaoshuai Wang
Max C. Wamsley
Colbee N. Duke
Payton H. Lii
Sarah E. Epley
London C. Todd
Patty J. Roberts
author_facet Ruipu Mu
Zhaoshuai Wang
Max C. Wamsley
Colbee N. Duke
Payton H. Lii
Sarah E. Epley
London C. Todd
Patty J. Roberts
author_sort Ruipu Mu
collection DOAJ
description Nowadays, biocatalysts have received much more attention in chemistry regarding their potential to enable high efficiency, high yield, and eco-friendly processes for a myriad of applications. Nature’s vast repository of catalysts has inspired synthetic chemists. Furthermore, the revolutionary technologies in bioengineering have provided the fast discovery and evolution of enzymes that empower chemical synthesis. This article attempts to deliver a comprehensive overview of the last two decades of investigation into enzymatic reactions and highlights the effective performance progress of bio-enzymes exploited in organic synthesis. Based on the types of enzymatic reactions and enzyme commission (E.C.) numbers, the enzymes discussed in the article are classified into oxidoreductases, transferases, hydrolases, and lyases. These applications should provide us with some insight into enzyme design strategies and molecular mechanisms.
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spelling doaj.art-946b4ab261cc484caee6e58b982ec6122023-11-20T07:47:34ZengMDPI AGCatalysts2073-43442020-07-0110883210.3390/catal10080832Application of Enzymes in Regioselective and Stereoselective Organic ReactionsRuipu Mu0Zhaoshuai Wang1Max C. Wamsley2Colbee N. Duke3Payton H. Lii4Sarah E. Epley5London C. Todd6Patty J. Roberts7Department of Chemistry, Centenary College of Louisiana, Shreveport, LA 71104, USADepartment of Pharmaceutical Science, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USADepartment of Chemistry, Centenary College of Louisiana, Shreveport, LA 71104, USADepartment of Chemistry, Centenary College of Louisiana, Shreveport, LA 71104, USADepartment of Chemistry, Centenary College of Louisiana, Shreveport, LA 71104, USADepartment of Chemistry, Centenary College of Louisiana, Shreveport, LA 71104, USADepartment of Chemistry, Centenary College of Louisiana, Shreveport, LA 71104, USADepartment of Chemistry, Centenary College of Louisiana, Shreveport, LA 71104, USANowadays, biocatalysts have received much more attention in chemistry regarding their potential to enable high efficiency, high yield, and eco-friendly processes for a myriad of applications. Nature’s vast repository of catalysts has inspired synthetic chemists. Furthermore, the revolutionary technologies in bioengineering have provided the fast discovery and evolution of enzymes that empower chemical synthesis. This article attempts to deliver a comprehensive overview of the last two decades of investigation into enzymatic reactions and highlights the effective performance progress of bio-enzymes exploited in organic synthesis. Based on the types of enzymatic reactions and enzyme commission (E.C.) numbers, the enzymes discussed in the article are classified into oxidoreductases, transferases, hydrolases, and lyases. These applications should provide us with some insight into enzyme design strategies and molecular mechanisms.https://www.mdpi.com/2073-4344/10/8/832regioselectivitystereoselectivitybiocatalystenzymatic reactionsprotein engineering
spellingShingle Ruipu Mu
Zhaoshuai Wang
Max C. Wamsley
Colbee N. Duke
Payton H. Lii
Sarah E. Epley
London C. Todd
Patty J. Roberts
Application of Enzymes in Regioselective and Stereoselective Organic Reactions
Catalysts
regioselectivity
stereoselectivity
biocatalyst
enzymatic reactions
protein engineering
title Application of Enzymes in Regioselective and Stereoselective Organic Reactions
title_full Application of Enzymes in Regioselective and Stereoselective Organic Reactions
title_fullStr Application of Enzymes in Regioselective and Stereoselective Organic Reactions
title_full_unstemmed Application of Enzymes in Regioselective and Stereoselective Organic Reactions
title_short Application of Enzymes in Regioselective and Stereoselective Organic Reactions
title_sort application of enzymes in regioselective and stereoselective organic reactions
topic regioselectivity
stereoselectivity
biocatalyst
enzymatic reactions
protein engineering
url https://www.mdpi.com/2073-4344/10/8/832
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