Vitamin D and Blood Parameters
Background: Vitamin D has a steroid- and an anabolic-resembling chemical structure. Vitamin D is essential for many processes in the human body after hydroxylation. Aims of the Study: To investigate the impact of 25-hydroxy-vitamin D plasma concentrations on the blood parameters number of erythrocyt...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/7/1017 |
| _version_ | 1797527544758534144 |
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| author | Thomas Müller Lutz Lohse Andreas Blodau Katja Frommholz |
| author_facet | Thomas Müller Lutz Lohse Andreas Blodau Katja Frommholz |
| author_sort | Thomas Müller |
| collection | DOAJ |
| description | Background: Vitamin D has a steroid- and an anabolic-resembling chemical structure. Vitamin D is essential for many processes in the human body after hydroxylation. Aims of the Study: To investigate the impact of 25-hydroxy-vitamin D plasma concentrations on the blood parameters number of erythrocytes, hematocrit, mean corpuscular hemoglobin and mean corpuscular volume. Methods: Serial assessments were done in 290 patients with multiple sclerosis and repeated after a mean interval of 245 days. A recommendation for vitamin D supplementation was given in case of a concentration lower than 20 ng/mL combined with a prescription of a formulation containing vitamin D but not vitamin K. Results: There was a fall of vitamin D in 119 subjects and a rise in 164, while no change appeared in 7 participants. When vitamin D values went down between both assessments moments, the computed increase of mean corpuscular haemoglobin was significantly lower compared with the rise of mean corpuscular haemoglobin associated with a vitamin D elevation. When vitamin D declined, the computed fall of mean corpuscular volume fall was significantly lower compared with the decrease of mean corpuscular volume, when vitamin D rose. Positive correlations were found between differences of vitamin D and mean corpuscular haemoglobin, respectively mean corpuscular volume. Inverse relations appeared between disparities of vitamin D and erythrocytes, respectively haematocrit. Conclusions: The elevation of vitamin D plasma levels provides enhanced preconditions for a better tissue oxygenation on a cellular level. |
| first_indexed | 2024-03-10T09:45:12Z |
| format | Article |
| id | doaj.art-946b74c74d14406da0adc9e83ecd37fe |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T09:45:12Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-946b74c74d14406da0adc9e83ecd37fe2023-11-22T03:18:51ZengMDPI AGBiomolecules2218-273X2021-07-01117101710.3390/biom11071017Vitamin D and Blood ParametersThomas Müller0Lutz Lohse1Andreas Blodau2Katja Frommholz3Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstr. 1, 13088 Berlin, GermanyMFSZ GmbH, Sternstr 28, 01139 Dresden, GermanyPrivate Practice, Kornhausstr 85, 06846 Dessau-Roßlau, GermanyDepartment of Radiology, Klinikum Frankfurt (Oder) GmbH, Müllroser Chaussee 7, 15236 Frankfurt, GermanyBackground: Vitamin D has a steroid- and an anabolic-resembling chemical structure. Vitamin D is essential for many processes in the human body after hydroxylation. Aims of the Study: To investigate the impact of 25-hydroxy-vitamin D plasma concentrations on the blood parameters number of erythrocytes, hematocrit, mean corpuscular hemoglobin and mean corpuscular volume. Methods: Serial assessments were done in 290 patients with multiple sclerosis and repeated after a mean interval of 245 days. A recommendation for vitamin D supplementation was given in case of a concentration lower than 20 ng/mL combined with a prescription of a formulation containing vitamin D but not vitamin K. Results: There was a fall of vitamin D in 119 subjects and a rise in 164, while no change appeared in 7 participants. When vitamin D values went down between both assessments moments, the computed increase of mean corpuscular haemoglobin was significantly lower compared with the rise of mean corpuscular haemoglobin associated with a vitamin D elevation. When vitamin D declined, the computed fall of mean corpuscular volume fall was significantly lower compared with the decrease of mean corpuscular volume, when vitamin D rose. Positive correlations were found between differences of vitamin D and mean corpuscular haemoglobin, respectively mean corpuscular volume. Inverse relations appeared between disparities of vitamin D and erythrocytes, respectively haematocrit. Conclusions: The elevation of vitamin D plasma levels provides enhanced preconditions for a better tissue oxygenation on a cellular level.https://www.mdpi.com/2218-273X/11/7/1017vitamin Dbloodhaematocrit |
| spellingShingle | Thomas Müller Lutz Lohse Andreas Blodau Katja Frommholz Vitamin D and Blood Parameters Biomolecules vitamin D blood haematocrit |
| title | Vitamin D and Blood Parameters |
| title_full | Vitamin D and Blood Parameters |
| title_fullStr | Vitamin D and Blood Parameters |
| title_full_unstemmed | Vitamin D and Blood Parameters |
| title_short | Vitamin D and Blood Parameters |
| title_sort | vitamin d and blood parameters |
| topic | vitamin D blood haematocrit |
| url | https://www.mdpi.com/2218-273X/11/7/1017 |
| work_keys_str_mv | AT thomasmuller vitamindandbloodparameters AT lutzlohse vitamindandbloodparameters AT andreasblodau vitamindandbloodparameters AT katjafrommholz vitamindandbloodparameters |