Pharmacologic Activation of the G Protein–Coupled Estrogen Receptor Inhibits Pancreatic Ductal AdenocarcinomaSummary

Pharmacologic Activation of the G Protein–Coupled Estrogen Receptor Inhibits Pancreatic Ductal AdenocarcinomaSummary

Background & Aims: Female sex is associated with lower incidence and improved clinical outcomes for most cancer types including pancreatic ductal adenocarcinoma (PDAC). The mechanistic basis for this sex difference is unknown. We hypothesized that estrogen signaling may be responsible, despi...

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Bibliographic Details
Main Authors: Christopher A. Natale, Jinyang Li, Jason R. Pitarresi, Robert J. Norgard, Tzvete Dentchev, Brian C. Capell, John T. Seykora, Ben Z. Stanger, Todd W. Ridky
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Pancreatic Ductal Adenocarcinoma
PDAC
G Protein-Coupled Estrogen Receptor
GPER
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X20300667

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