From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain Disorders
The brain’s sensitivity to oxidative stress and neuronal cell death requires effective pharmacotherapy approaches. Current pharmacological therapies are frequently ineffective and display negative side effects. Bioactive chemicals found in plants may provide a potential alternative due to their anti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/8/1603 |
| _version_ | 1797585696589873152 |
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| author | Clara Grosso Marlene Santos M. Fátima Barroso |
| author_facet | Clara Grosso Marlene Santos M. Fátima Barroso |
| author_sort | Clara Grosso |
| collection | DOAJ |
| description | The brain’s sensitivity to oxidative stress and neuronal cell death requires effective pharmacotherapy approaches. Current pharmacological therapies are frequently ineffective and display negative side effects. Bioactive chemicals found in plants may provide a potential alternative due to their antioxidant and neuroprotective properties and can be used in therapy and the management of a variety of neuropsychiatric, neurodevelopmental, and neurodegenerative illnesses. Several natural products, including vitamin C, <i>Cammelia sinensis</i> polyphenols, <i>Hypericum perforatum</i>, and <i>Crocus sativus</i> have shown promise in lowering oxidative stress and treating symptoms of major depressive disorder (MDD). Similarly, bioactive compounds such as curcumin, luteolin, resveratrol, quercetin, and plants like <i>Acorus gramineus</i>, <i>Rhodiola rosea</i>, and <i>Ginkgo biloba</i> are associated with neuroprotective effects and symptom improvement in neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). Furthermore, in neurodegenerative diseases, natural compounds from <i>Rhodiola rosea</i>, <i>Morinda lucida</i>, and <i>Glutinous rehmannia</i> provide neurological improvement. Further study in clinical samples is required to thoroughly investigate the therapeutic advantages of these bioactive substances for persons suffering from these illnesses. |
| first_indexed | 2024-03-11T00:10:43Z |
| format | Article |
| id | doaj.art-946cd1b152fa4d52956e524aae2d0d0d |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T00:10:43Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-946cd1b152fa4d52956e524aae2d0d0d2023-11-19T00:02:36ZengMDPI AGAntioxidants2076-39212023-08-01128160310.3390/antiox12081603From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain DisordersClara Grosso0Marlene Santos1M. Fátima Barroso2REQUIMTE–LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, PortugalCISA|ESS, Centro de Investigação em Saúde e Ambiente, Escola Superior de Saúde, Polytechnic Institute of Porto, Rua Dr. António Bernardino de Almeida 400, 4200-072 Porto, PortugalREQUIMTE–LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, PortugalThe brain’s sensitivity to oxidative stress and neuronal cell death requires effective pharmacotherapy approaches. Current pharmacological therapies are frequently ineffective and display negative side effects. Bioactive chemicals found in plants may provide a potential alternative due to their antioxidant and neuroprotective properties and can be used in therapy and the management of a variety of neuropsychiatric, neurodevelopmental, and neurodegenerative illnesses. Several natural products, including vitamin C, <i>Cammelia sinensis</i> polyphenols, <i>Hypericum perforatum</i>, and <i>Crocus sativus</i> have shown promise in lowering oxidative stress and treating symptoms of major depressive disorder (MDD). Similarly, bioactive compounds such as curcumin, luteolin, resveratrol, quercetin, and plants like <i>Acorus gramineus</i>, <i>Rhodiola rosea</i>, and <i>Ginkgo biloba</i> are associated with neuroprotective effects and symptom improvement in neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). Furthermore, in neurodegenerative diseases, natural compounds from <i>Rhodiola rosea</i>, <i>Morinda lucida</i>, and <i>Glutinous rehmannia</i> provide neurological improvement. Further study in clinical samples is required to thoroughly investigate the therapeutic advantages of these bioactive substances for persons suffering from these illnesses.https://www.mdpi.com/2076-3921/12/8/1603oxidative stresspsychiatric disordersneurodevelopmental disordersneurodegenerative disordersphenolic compoundsplant-derived bioactive compounds |
| spellingShingle | Clara Grosso Marlene Santos M. Fátima Barroso From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain Disorders Antioxidants oxidative stress psychiatric disorders neurodevelopmental disorders neurodegenerative disorders phenolic compounds plant-derived bioactive compounds |
| title | From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain Disorders |
| title_full | From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain Disorders |
| title_fullStr | From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain Disorders |
| title_full_unstemmed | From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain Disorders |
| title_short | From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain Disorders |
| title_sort | from plants to psycho neurology unravelling the therapeutic benefits of bioactive compounds in brain disorders |
| topic | oxidative stress psychiatric disorders neurodevelopmental disorders neurodegenerative disorders phenolic compounds plant-derived bioactive compounds |
| url | https://www.mdpi.com/2076-3921/12/8/1603 |
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