Alternative Polyadenylation Characterizes Epithelial and Fibroblast Phenotypic Heterogeneity in Pancreatic Ductal Adenocarcinoma

Alternative Polyadenylation Characterizes Epithelial and Fibroblast Phenotypic Heterogeneity in Pancreatic Ductal Adenocarcinoma

Human tumors are characterized by extensive intratumoral transcriptional variability within the cancer cell and stromal compartments. This variation drives phenotypic heterogeneity, producing cell states with differential pro- and anti-tumorigenic properties. While bulk RNA sequencing cannot achieve...

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Bibliographic Details
Main Authors: Swati Venkat, Michael E. Feigin
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cancers
Subjects:
alternative polyadenyation
gene regulation
pancreatic cancer
Online Access:https://www.mdpi.com/2072-6694/16/3/640

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