The effect of midazolam on pain control after knee arthroscopy: a systematic review and meta-analysis
Abstract Background Midazolam has some potential in pain control of patients undergoing knee arthroscopy. However, the results remain controversial. We conduct a systematic review and meta-analysis to explore the effect of midazolam on pain control after knee arthroscopy. Methods PubMed, EMbase, Web...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-11-01
|
| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-017-0682-0 |
| _version_ | 1797999824618913792 |
|---|---|
| author | Xiaojun Chen Xiaoqing Mou Zhiyu He Yong Zhu |
| author_facet | Xiaojun Chen Xiaoqing Mou Zhiyu He Yong Zhu |
| author_sort | Xiaojun Chen |
| collection | DOAJ |
| description | Abstract Background Midazolam has some potential in pain control of patients undergoing knee arthroscopy. However, the results remain controversial. We conduct a systematic review and meta-analysis to explore the effect of midazolam on pain control after knee arthroscopy. Methods PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases are systematically searched. Randomized controlled trials (RCTs) assessing the effect of midazolam on pain management after knee arthroscopy are included. Two investigators have independently searched articles, extracted the data, and assessed the quality of the included studies. This meta-analysis is performed using the random-effect model. Results Six RCTs are included in this meta-analysis. Compared with control intervention after knee arthroscopy, midazolam intervention can significantly reduce the pain scores (standard mean difference (Std. MD) = − 3.70; 95% confidence interval (CI) = − 6.81 to − 0.60; P = 0.02), the number of patients requiring analgesics (risk ratio (RR) = 0.66; 95% CI = 0.49 to 0.88; P = 0.005), and analgesic consumption (Std. MD = −1.62; 95% CI = − 3.04 to − 0.19; P = 0.03), as well as increase the time to first analgesic requirement (Std. MD = 1.58; 95% CI = 0.17 to 2.99; P = 0.03). In addition, midazolam intervention results in no increase in adverse events following knee arthroscopy (RR = 0.74; 95% CI = 0.18 to 2.98; P = 0.67). Conclusions Midazolam intervention is revealed to substantially reduce the pain scores, the number of patients requiring analgesics, and analgesic consumption, as well as improve the time to first analgesic requirement after knee arthroscopy. |
| first_indexed | 2024-04-11T11:10:53Z |
| format | Article |
| id | doaj.art-9471114c70be424ebc3490aff022c40f |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T11:10:53Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-9471114c70be424ebc3490aff022c40f2022-12-22T04:27:28ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2017-11-011211610.1186/s13018-017-0682-0The effect of midazolam on pain control after knee arthroscopy: a systematic review and meta-analysisXiaojun Chen0Xiaoqing Mou1Zhiyu He2Yong Zhu3Department of Orthopaedics, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityDepartment of Radiology, the Affiliated Hospital of Southwest Medical UniversityDepartment of Orthopaedics, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityDepartment of Orthopaedics, the First Affiliated Hospital of Chongqing medical universityAbstract Background Midazolam has some potential in pain control of patients undergoing knee arthroscopy. However, the results remain controversial. We conduct a systematic review and meta-analysis to explore the effect of midazolam on pain control after knee arthroscopy. Methods PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases are systematically searched. Randomized controlled trials (RCTs) assessing the effect of midazolam on pain management after knee arthroscopy are included. Two investigators have independently searched articles, extracted the data, and assessed the quality of the included studies. This meta-analysis is performed using the random-effect model. Results Six RCTs are included in this meta-analysis. Compared with control intervention after knee arthroscopy, midazolam intervention can significantly reduce the pain scores (standard mean difference (Std. MD) = − 3.70; 95% confidence interval (CI) = − 6.81 to − 0.60; P = 0.02), the number of patients requiring analgesics (risk ratio (RR) = 0.66; 95% CI = 0.49 to 0.88; P = 0.005), and analgesic consumption (Std. MD = −1.62; 95% CI = − 3.04 to − 0.19; P = 0.03), as well as increase the time to first analgesic requirement (Std. MD = 1.58; 95% CI = 0.17 to 2.99; P = 0.03). In addition, midazolam intervention results in no increase in adverse events following knee arthroscopy (RR = 0.74; 95% CI = 0.18 to 2.98; P = 0.67). Conclusions Midazolam intervention is revealed to substantially reduce the pain scores, the number of patients requiring analgesics, and analgesic consumption, as well as improve the time to first analgesic requirement after knee arthroscopy.http://link.springer.com/article/10.1186/s13018-017-0682-0MidazolamPain controlKnee arthroscopyPain scoresMeta-analysis |
| spellingShingle | Xiaojun Chen Xiaoqing Mou Zhiyu He Yong Zhu The effect of midazolam on pain control after knee arthroscopy: a systematic review and meta-analysis Journal of Orthopaedic Surgery and Research Midazolam Pain control Knee arthroscopy Pain scores Meta-analysis |
| title | The effect of midazolam on pain control after knee arthroscopy: a systematic review and meta-analysis |
| title_full | The effect of midazolam on pain control after knee arthroscopy: a systematic review and meta-analysis |
| title_fullStr | The effect of midazolam on pain control after knee arthroscopy: a systematic review and meta-analysis |
| title_full_unstemmed | The effect of midazolam on pain control after knee arthroscopy: a systematic review and meta-analysis |
| title_short | The effect of midazolam on pain control after knee arthroscopy: a systematic review and meta-analysis |
| title_sort | effect of midazolam on pain control after knee arthroscopy a systematic review and meta analysis |
| topic | Midazolam Pain control Knee arthroscopy Pain scores Meta-analysis |
| url | http://link.springer.com/article/10.1186/s13018-017-0682-0 |
| work_keys_str_mv | AT xiaojunchen theeffectofmidazolamonpaincontrolafterkneearthroscopyasystematicreviewandmetaanalysis AT xiaoqingmou theeffectofmidazolamonpaincontrolafterkneearthroscopyasystematicreviewandmetaanalysis AT zhiyuhe theeffectofmidazolamonpaincontrolafterkneearthroscopyasystematicreviewandmetaanalysis AT yongzhu theeffectofmidazolamonpaincontrolafterkneearthroscopyasystematicreviewandmetaanalysis AT xiaojunchen effectofmidazolamonpaincontrolafterkneearthroscopyasystematicreviewandmetaanalysis AT xiaoqingmou effectofmidazolamonpaincontrolafterkneearthroscopyasystematicreviewandmetaanalysis AT zhiyuhe effectofmidazolamonpaincontrolafterkneearthroscopyasystematicreviewandmetaanalysis AT yongzhu effectofmidazolamonpaincontrolafterkneearthroscopyasystematicreviewandmetaanalysis |