Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable cation channel required for immune cell activation, insulin secretion, and body heat control. TRPM2 is activated by cytosolic Ca2+, phosphatidyl-inositol-4,5-bisphosphate and ADP ribose. Here, we present the ~3 Å resolution electr...

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Bibliographic Details
Main Authors: Zhe Zhang, Balázs Tóth, Andras Szollosi, Jue Chen, László Csanády
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
cryo-EM
patch-clamp
ion channel
structure-function
gating
permeation
Online Access:https://elifesciences.org/articles/36409

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