Informant-reported cognitive symptoms that predict amnestic mild cognitive impairment
<p>Abstract</p> <p>Background</p> <p>Differentiating amnestic mild cognitive impairment (aMCI) from normal cognition is difficult in clinical settings. Self-reported and informant-reported memory complaints occur often in both clinical groups, which then necessitates th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-02-01
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| Series: | BMC Geriatrics |
| Online Access: | http://www.biomedcentral.com/1471-2318/12/3 |
| _version_ | 1828463287548772352 |
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| author | Malek-Ahmadi Michael Davis Kathryn Belden Christine M Jacobson Sandra Sabbagh Marwan N |
| author_facet | Malek-Ahmadi Michael Davis Kathryn Belden Christine M Jacobson Sandra Sabbagh Marwan N |
| author_sort | Malek-Ahmadi Michael |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Differentiating amnestic mild cognitive impairment (aMCI) from normal cognition is difficult in clinical settings. Self-reported and informant-reported memory complaints occur often in both clinical groups, which then necessitates the use of a comprehensive neuropsychological examination to make a differential diagnosis. However, the ability to identify cognitive symptoms that are predictive of aMCI through informant-based information may provide some clinical utility in accurately identifying individuals who are at risk for developing Alzheimer's disease (AD).</p> <p>Methods</p> <p>The current study utilized a case-control design using data from an ongoing validation study of the Alzheimer's Questionnaire (AQ), an informant-based dementia assessment. Data from 51 cognitively normal (CN) individuals participating in a brain donation program and 47 aMCI individuals seen in a neurology practice at the same institute were analyzed to determine which AQ items differentiated aMCI from CN individuals.</p> <p>Results</p> <p>Forward stepwise multiple logistic regression analysis which controlled for age and education showed that 4 AQ items were strong indicators of aMCI which included: repetition of statements and/or questions [OR 13.20 (3.02, 57.66)]; trouble knowing the day, date, month, year, and time [OR 17.97 (2.63, 122.77)]; difficulty managing finances [OR 11.60 (2.10, 63.99)]; and decreased sense of direction [OR 5.84 (1.09, 31.30)].</p> <p>Conclusions</p> <p>Overall, these data indicate that certain informant-reported cognitive symptoms may help clinicians differentiate individuals with aMCI from those with normal cognition. Items pertaining to repetition of statements, orientation, ability to manage finances, and visuospatial disorientation had high discriminatory power.</p> |
| first_indexed | 2024-12-11T02:52:42Z |
| format | Article |
| id | doaj.art-9475c9b01e254e12ba0f0fff6973ba02 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-11T02:52:42Z |
| publishDate | 2012-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-9475c9b01e254e12ba0f0fff6973ba022022-12-22T01:23:16ZengBMCBMC Geriatrics1471-23182012-02-01121310.1186/1471-2318-12-3Informant-reported cognitive symptoms that predict amnestic mild cognitive impairmentMalek-Ahmadi MichaelDavis KathrynBelden Christine MJacobson SandraSabbagh Marwan N<p>Abstract</p> <p>Background</p> <p>Differentiating amnestic mild cognitive impairment (aMCI) from normal cognition is difficult in clinical settings. Self-reported and informant-reported memory complaints occur often in both clinical groups, which then necessitates the use of a comprehensive neuropsychological examination to make a differential diagnosis. However, the ability to identify cognitive symptoms that are predictive of aMCI through informant-based information may provide some clinical utility in accurately identifying individuals who are at risk for developing Alzheimer's disease (AD).</p> <p>Methods</p> <p>The current study utilized a case-control design using data from an ongoing validation study of the Alzheimer's Questionnaire (AQ), an informant-based dementia assessment. Data from 51 cognitively normal (CN) individuals participating in a brain donation program and 47 aMCI individuals seen in a neurology practice at the same institute were analyzed to determine which AQ items differentiated aMCI from CN individuals.</p> <p>Results</p> <p>Forward stepwise multiple logistic regression analysis which controlled for age and education showed that 4 AQ items were strong indicators of aMCI which included: repetition of statements and/or questions [OR 13.20 (3.02, 57.66)]; trouble knowing the day, date, month, year, and time [OR 17.97 (2.63, 122.77)]; difficulty managing finances [OR 11.60 (2.10, 63.99)]; and decreased sense of direction [OR 5.84 (1.09, 31.30)].</p> <p>Conclusions</p> <p>Overall, these data indicate that certain informant-reported cognitive symptoms may help clinicians differentiate individuals with aMCI from those with normal cognition. Items pertaining to repetition of statements, orientation, ability to manage finances, and visuospatial disorientation had high discriminatory power.</p>http://www.biomedcentral.com/1471-2318/12/3 |
| spellingShingle | Malek-Ahmadi Michael Davis Kathryn Belden Christine M Jacobson Sandra Sabbagh Marwan N Informant-reported cognitive symptoms that predict amnestic mild cognitive impairment BMC Geriatrics |
| title | Informant-reported cognitive symptoms that predict amnestic mild cognitive impairment |
| title_full | Informant-reported cognitive symptoms that predict amnestic mild cognitive impairment |
| title_fullStr | Informant-reported cognitive symptoms that predict amnestic mild cognitive impairment |
| title_full_unstemmed | Informant-reported cognitive symptoms that predict amnestic mild cognitive impairment |
| title_short | Informant-reported cognitive symptoms that predict amnestic mild cognitive impairment |
| title_sort | informant reported cognitive symptoms that predict amnestic mild cognitive impairment |
| url | http://www.biomedcentral.com/1471-2318/12/3 |
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