ELAC2 Functions as a Key Gene in the Early Development of Placental Formation Based on WGCNA
The placenta plays a crucial role in mammalian fetal growth. The most important cell type in the placenta is the trophoblast cell. Many genes have been reported to play important functions in the differentiation of early placental trophoblast cells. Weighted gene co-expression network analysis (WGCN...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/4/613 |
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| author | Junyong Liang Jingjie Liang Qiang Tan Zhengguang Wang |
| author_facet | Junyong Liang Jingjie Liang Qiang Tan Zhengguang Wang |
| author_sort | Junyong Liang |
| collection | DOAJ |
| description | The placenta plays a crucial role in mammalian fetal growth. The most important cell type in the placenta is the trophoblast cell. Many genes have been reported to play important functions in the differentiation of early placental trophoblast cells. Weighted gene co-expression network analysis (WGCNA) is a systematic biological method for describing the correlation patterns among genes across microarray samples. We used WGCNA to screen placental trophoblast development-related genes, and through experimental confirmation, we showed that, among these genes, ELAC2 may play an important regulatory role in the early development of mammalian placental formation. ELAC2 regulates early placental trophoblast differentiation by affecting cell migration and cell proliferation. In addition, ELAC2 may be involved in regulating cell migration processes in a manner that affects epithelial mesenchymal transition (EMT). |
| first_indexed | 2024-03-11T09:01:03Z |
| format | Article |
| id | doaj.art-9478353d3e0a431ba44b5bd7b0156949 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T09:01:03Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9478353d3e0a431ba44b5bd7b01569492023-11-16T19:44:48ZengMDPI AGCells2073-44092023-02-0112461310.3390/cells12040613ELAC2 Functions as a Key Gene in the Early Development of Placental Formation Based on WGCNAJunyong Liang0Jingjie Liang1Qiang Tan2Zhengguang Wang3College of Animal Sciences, Zhejiang University, Hangzhou 310000, ChinaCollege of Animal Sciences, Zhejiang University, Hangzhou 310000, ChinaCollege of Animal Sciences, Zhejiang University, Hangzhou 310000, ChinaCollege of Animal Sciences, Zhejiang University, Hangzhou 310000, ChinaThe placenta plays a crucial role in mammalian fetal growth. The most important cell type in the placenta is the trophoblast cell. Many genes have been reported to play important functions in the differentiation of early placental trophoblast cells. Weighted gene co-expression network analysis (WGCNA) is a systematic biological method for describing the correlation patterns among genes across microarray samples. We used WGCNA to screen placental trophoblast development-related genes, and through experimental confirmation, we showed that, among these genes, ELAC2 may play an important regulatory role in the early development of mammalian placental formation. ELAC2 regulates early placental trophoblast differentiation by affecting cell migration and cell proliferation. In addition, ELAC2 may be involved in regulating cell migration processes in a manner that affects epithelial mesenchymal transition (EMT).https://www.mdpi.com/2073-4409/12/4/613placentaWGCNAELAC2EMT |
| spellingShingle | Junyong Liang Jingjie Liang Qiang Tan Zhengguang Wang ELAC2 Functions as a Key Gene in the Early Development of Placental Formation Based on WGCNA Cells placenta WGCNA ELAC2 EMT |
| title | ELAC2 Functions as a Key Gene in the Early Development of Placental Formation Based on WGCNA |
| title_full | ELAC2 Functions as a Key Gene in the Early Development of Placental Formation Based on WGCNA |
| title_fullStr | ELAC2 Functions as a Key Gene in the Early Development of Placental Formation Based on WGCNA |
| title_full_unstemmed | ELAC2 Functions as a Key Gene in the Early Development of Placental Formation Based on WGCNA |
| title_short | ELAC2 Functions as a Key Gene in the Early Development of Placental Formation Based on WGCNA |
| title_sort | elac2 functions as a key gene in the early development of placental formation based on wgcna |
| topic | placenta WGCNA ELAC2 EMT |
| url | https://www.mdpi.com/2073-4409/12/4/613 |
| work_keys_str_mv | AT junyongliang elac2functionsasakeygeneintheearlydevelopmentofplacentalformationbasedonwgcna AT jingjieliang elac2functionsasakeygeneintheearlydevelopmentofplacentalformationbasedonwgcna AT qiangtan elac2functionsasakeygeneintheearlydevelopmentofplacentalformationbasedonwgcna AT zhengguangwang elac2functionsasakeygeneintheearlydevelopmentofplacentalformationbasedonwgcna |