In Vitro and In Vivo Anti-inflammatory Activity of Bovine Milkfat Globule (MFGM)-derived Complex Lipid Fractions
Numerous health related properties have been reported for bovine milk fat globule membrane (MFGM) and its components. Here we present novel data on the in vitro and in vivo anti-inflammatory activity of various MFGM preparations which confirm and extend the concept of MFGM as a dietary anti-inflamma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/7/2089 |
| _version_ | 1797562409482715136 |
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| author | Kate P. Palmano Alastair K. H. MacGibbon Caroline A. Gunn Linda M. Schollum |
| author_facet | Kate P. Palmano Alastair K. H. MacGibbon Caroline A. Gunn Linda M. Schollum |
| author_sort | Kate P. Palmano |
| collection | DOAJ |
| description | Numerous health related properties have been reported for bovine milk fat globule membrane (MFGM) and its components. Here we present novel data on the in vitro and in vivo anti-inflammatory activity of various MFGM preparations which confirm and extend the concept of MFGM as a dietary anti-inflammatory agent. Cell-based assays were used to test the ability of MFGM preparations to modulate levels of the inflammatory mediators IL-1β, nitric oxide, superoxide anion, cyclo-oxygenase-2, and neutrophil elastase. In rat models of arthritis, using MFGM fractions as dietary interventions, the phospholipid-enriched MFGM isolates were effective in reducing adjuvant-induced paw swelling while there was a tendency for the ganglioside-enriched isolate to reduce carrageenan-induced rat paw oedema. These results indicate that the anti-inflammatory activity of MFGM, rather than residing in a single component, is contributed to by an array of components acting in concert against various inflammatory targets. This confirms the potential of MFGM as a nutritional intervention for the mitigation of chronic and acute inflammatory conditions. |
| first_indexed | 2024-03-10T18:28:49Z |
| format | Article |
| id | doaj.art-947a223d6e9a48ba80bcb14b45f6dabf |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T18:28:49Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-947a223d6e9a48ba80bcb14b45f6dabf2023-11-20T06:48:21ZengMDPI AGNutrients2072-66432020-07-01127208910.3390/nu12072089In Vitro and In Vivo Anti-inflammatory Activity of Bovine Milkfat Globule (MFGM)-derived Complex Lipid FractionsKate P. Palmano0Alastair K. H. MacGibbon1Caroline A. Gunn2Linda M. Schollum3Retired from Fonterra Research & Development Centre, Palmerston North 4442, New ZealandFonterra Research & Development Centre, Palmerston North 4442, New ZealandFonterra Research & Development Centre, Palmerston North 4442, New ZealandFonterra Research & Development Centre, Palmerston North 4442, New ZealandNumerous health related properties have been reported for bovine milk fat globule membrane (MFGM) and its components. Here we present novel data on the in vitro and in vivo anti-inflammatory activity of various MFGM preparations which confirm and extend the concept of MFGM as a dietary anti-inflammatory agent. Cell-based assays were used to test the ability of MFGM preparations to modulate levels of the inflammatory mediators IL-1β, nitric oxide, superoxide anion, cyclo-oxygenase-2, and neutrophil elastase. In rat models of arthritis, using MFGM fractions as dietary interventions, the phospholipid-enriched MFGM isolates were effective in reducing adjuvant-induced paw swelling while there was a tendency for the ganglioside-enriched isolate to reduce carrageenan-induced rat paw oedema. These results indicate that the anti-inflammatory activity of MFGM, rather than residing in a single component, is contributed to by an array of components acting in concert against various inflammatory targets. This confirms the potential of MFGM as a nutritional intervention for the mitigation of chronic and acute inflammatory conditions.https://www.mdpi.com/2072-6643/12/7/2089MFGMphospholipidsgangliosidesdairyinflammationpolar lipids |
| spellingShingle | Kate P. Palmano Alastair K. H. MacGibbon Caroline A. Gunn Linda M. Schollum In Vitro and In Vivo Anti-inflammatory Activity of Bovine Milkfat Globule (MFGM)-derived Complex Lipid Fractions Nutrients MFGM phospholipids gangliosides dairy inflammation polar lipids |
| title | In Vitro and In Vivo Anti-inflammatory Activity of Bovine Milkfat Globule (MFGM)-derived Complex Lipid Fractions |
| title_full | In Vitro and In Vivo Anti-inflammatory Activity of Bovine Milkfat Globule (MFGM)-derived Complex Lipid Fractions |
| title_fullStr | In Vitro and In Vivo Anti-inflammatory Activity of Bovine Milkfat Globule (MFGM)-derived Complex Lipid Fractions |
| title_full_unstemmed | In Vitro and In Vivo Anti-inflammatory Activity of Bovine Milkfat Globule (MFGM)-derived Complex Lipid Fractions |
| title_short | In Vitro and In Vivo Anti-inflammatory Activity of Bovine Milkfat Globule (MFGM)-derived Complex Lipid Fractions |
| title_sort | in vitro and in vivo anti inflammatory activity of bovine milkfat globule mfgm derived complex lipid fractions |
| topic | MFGM phospholipids gangliosides dairy inflammation polar lipids |
| url | https://www.mdpi.com/2072-6643/12/7/2089 |
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