Matrix metalloproteinase 9 gene promoter region -1562 C/T single nucleotide polymorphism increases the susceptibility to hypertensive disorders of pregnancy: a meta-analysis
Hypertensive disorders of pregnancy (HDP) encompass a group of diseases. Single nucleotide polymorphisms (SNPs) are common in the matrix metalloproteinase 9 (MMP9) genes. The objective of this study was to analyse whether genetic polymorphisms in MMP9-1562 C/T alter the risk of HDP. Studies publishe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2021-04-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/48/2/10.31083/j.ceog.2021.02.2265 |
| _version_ | 1811247838397464576 |
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| author | Yi Zhou Ran Wang Shi-Xian Chen Li-Sheng Wu Jun-Qing Zhu |
| author_facet | Yi Zhou Ran Wang Shi-Xian Chen Li-Sheng Wu Jun-Qing Zhu |
| author_sort | Yi Zhou |
| collection | DOAJ |
| description | Hypertensive disorders of pregnancy (HDP) encompass a group of diseases. Single nucleotide polymorphisms (SNPs) are common in the matrix metalloproteinase 9 (MMP9) genes. The objective of this study was to analyse whether genetic polymorphisms in MMP9-1562 C/T alter the risk of HDP. Studies published up to October 2019 across PubMed, ScienceDirect, SpringerLink, and China National Knowledge Infrastructure database were searched. Case-control or cohort studies involving subtypes of HDP and distribution of genotypes and/or alleles within MMP9-1562 C/T in both patients and controls were selected. Number of genotypes and/or alleles for MMP9-1562 C/T polymorphisms were obtained and analyzed using Stata software. Eight published reports including 1300 HDP patients and 1612 controls were included in the meta-analysis. Results showed that a variant genotype and allele of MMP9-1562 C/T increased the risk of HDP, with pooled OR 1.50 (95% CI 1.16–1.95, P = 0.002) and 1.36 (95% CI 1.15–1.61, P < 0.001). Subgroup analyses showed that the variant genotype and allele of MMP9-1562 C/T also had increased risk of preeclampsia (OR = 1.48, 1.32; 95% CI 1.18–1.86, 1.08–1.62; P = 0.001, 0.007) and gestational hypertension (OR = 2.23, 1.88; 95% CI 1.52–3.28, 1.33–2.65; P < 0.001, < 0.001) in the fixed-effects models. This suggests that variant genotype (TT + TC) and allele (T) of MMP9-1562 C/T are associated with susceptibility of HDP, especially preeclampsia and gestational hypertension. |
| first_indexed | 2024-04-12T15:16:32Z |
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| id | doaj.art-947ac3b99efa4d3a88bfcb81b7412d46 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-04-12T15:16:32Z |
| publishDate | 2021-04-01 |
| publisher | IMR Press |
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| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-947ac3b99efa4d3a88bfcb81b7412d462022-12-22T03:27:37ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632021-04-0148224525210.31083/j.ceog.2021.02.2265S0390-6663(21)00076-2Matrix metalloproteinase 9 gene promoter region -1562 C/T single nucleotide polymorphism increases the susceptibility to hypertensive disorders of pregnancy: a meta-analysisYi Zhou0Ran Wang1Shi-Xian Chen2Li-Sheng Wu3Jun-Qing Zhu4Department of Obstetrics, Guangdong Women and Children Hospital, 510510 Guangzhou, Guangdong, ChinaDepartment of Rheumatic & TCM Medical Center, Nanfang Hospital, Southern Medical University, 510510 Guangzhou, Guangdong, ChinaDepartment of Rheumatic & TCM Medical Center, Nanfang Hospital, Southern Medical University, 510510 Guangzhou, Guangdong, ChinaDepartment of Rheumatic & TCM Medical Center, Nanfang Hospital, Southern Medical University, 510510 Guangzhou, Guangdong, ChinaDepartment of Rheumatic & TCM Medical Center, Nanfang Hospital, Southern Medical University, 510510 Guangzhou, Guangdong, ChinaHypertensive disorders of pregnancy (HDP) encompass a group of diseases. Single nucleotide polymorphisms (SNPs) are common in the matrix metalloproteinase 9 (MMP9) genes. The objective of this study was to analyse whether genetic polymorphisms in MMP9-1562 C/T alter the risk of HDP. Studies published up to October 2019 across PubMed, ScienceDirect, SpringerLink, and China National Knowledge Infrastructure database were searched. Case-control or cohort studies involving subtypes of HDP and distribution of genotypes and/or alleles within MMP9-1562 C/T in both patients and controls were selected. Number of genotypes and/or alleles for MMP9-1562 C/T polymorphisms were obtained and analyzed using Stata software. Eight published reports including 1300 HDP patients and 1612 controls were included in the meta-analysis. Results showed that a variant genotype and allele of MMP9-1562 C/T increased the risk of HDP, with pooled OR 1.50 (95% CI 1.16–1.95, P = 0.002) and 1.36 (95% CI 1.15–1.61, P < 0.001). Subgroup analyses showed that the variant genotype and allele of MMP9-1562 C/T also had increased risk of preeclampsia (OR = 1.48, 1.32; 95% CI 1.18–1.86, 1.08–1.62; P = 0.001, 0.007) and gestational hypertension (OR = 2.23, 1.88; 95% CI 1.52–3.28, 1.33–2.65; P < 0.001, < 0.001) in the fixed-effects models. This suggests that variant genotype (TT + TC) and allele (T) of MMP9-1562 C/T are associated with susceptibility of HDP, especially preeclampsia and gestational hypertension.https://www.imrpress.com/journal/CEOG/48/2/10.31083/j.ceog.2021.02.2265hypertensive disorders of pregnancygestational hypertensionpreeclampsiamatrix metalloproteinase 9single nucleotide polymorphism |
| spellingShingle | Yi Zhou Ran Wang Shi-Xian Chen Li-Sheng Wu Jun-Qing Zhu Matrix metalloproteinase 9 gene promoter region -1562 C/T single nucleotide polymorphism increases the susceptibility to hypertensive disorders of pregnancy: a meta-analysis Clinical and Experimental Obstetrics & Gynecology hypertensive disorders of pregnancy gestational hypertension preeclampsia matrix metalloproteinase 9 single nucleotide polymorphism |
| title | Matrix metalloproteinase 9 gene promoter region -1562 C/T single nucleotide polymorphism increases the susceptibility to hypertensive disorders of pregnancy: a meta-analysis |
| title_full | Matrix metalloproteinase 9 gene promoter region -1562 C/T single nucleotide polymorphism increases the susceptibility to hypertensive disorders of pregnancy: a meta-analysis |
| title_fullStr | Matrix metalloproteinase 9 gene promoter region -1562 C/T single nucleotide polymorphism increases the susceptibility to hypertensive disorders of pregnancy: a meta-analysis |
| title_full_unstemmed | Matrix metalloproteinase 9 gene promoter region -1562 C/T single nucleotide polymorphism increases the susceptibility to hypertensive disorders of pregnancy: a meta-analysis |
| title_short | Matrix metalloproteinase 9 gene promoter region -1562 C/T single nucleotide polymorphism increases the susceptibility to hypertensive disorders of pregnancy: a meta-analysis |
| title_sort | matrix metalloproteinase 9 gene promoter region 1562 c t single nucleotide polymorphism increases the susceptibility to hypertensive disorders of pregnancy a meta analysis |
| topic | hypertensive disorders of pregnancy gestational hypertension preeclampsia matrix metalloproteinase 9 single nucleotide polymorphism |
| url | https://www.imrpress.com/journal/CEOG/48/2/10.31083/j.ceog.2021.02.2265 |
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