MTA1 Expression Correlates Significantly with Histologic Grade in Salivary Mucoepidermoid Carcinoma
Background: Metastasis associated protein-1 (MTA1) has been a recently identified as a unique gene playing important role in tumorigenesis and progression of cancer cells. Objective:To evaluate MTA1 expression and its predictive value in determining histologic grade of salivary mucoepidermoid carci...
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| Format: | Article |
| Language: | English |
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College of medicine/ University of Diyala
2019-03-01
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| Series: | Diyala Journal of Medicine |
| Subjects: | |
| Online Access: | http://djm.uodiyala.edu.iq/index.php/djm/article/view/193 |
| _version_ | 1827636441071484928 |
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| author | Omar I Ahmed Lehadh M Al-Azzawi Mustafa G Taher |
| author_facet | Omar I Ahmed Lehadh M Al-Azzawi Mustafa G Taher |
| author_sort | Omar I Ahmed |
| collection | DOAJ |
| description |
Background: Metastasis associated protein-1 (MTA1) has been a recently identified as a unique gene playing important role in tumorigenesis and progression of cancer cells. Objective:To evaluate MTA1 expression and its predictive value in determining histologic grade of salivary mucoepidermoid carcinoma (MEC).
Patients and Methods: MTA1 expression was evaluated by immunohistochemistry in paraffin-embedded tumor specimens blocks from 22 patients. Assessment of MTA1 immunostaining was achieved by counting the proportion of positively-stained tumor cells in 5 high power microscopic fields; and staining was analyzed in relation to clinicopathological variables.
Results: MTA1 show nuclear and cytoplasmic expression in varying intensity in 95% of cases. No significant correlation was found between MTA1expression and age, gender, site of the tumor (p>0.05). However, statistically significant correlation was found between MTA1expression and clinical stage, nodal involvement (p=0.009 and 0.007; respectively). Regarding histologic grade, high MTA1 level was significantly associated with grade of tumors categorized by Auclair and Brandwein systems (<0.001 and 0.009; respectively).
Conclusion:MTA1 expression significantly correlates with tumor grade and progression, and has a potential role in diagnosis and prediction of behavior in salivary MEC.
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| first_indexed | 2024-03-09T15:41:57Z |
| format | Article |
| id | doaj.art-947af7c8460d46f6929e52c986bcdabb |
| institution | Directory Open Access Journal |
| issn | 2219-9764 2617-8982 |
| language | English |
| last_indexed | 2024-03-09T15:41:57Z |
| publishDate | 2019-03-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj.art-947af7c8460d46f6929e52c986bcdabb2023-11-24T23:24:29ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822019-03-01161MTA1 Expression Correlates Significantly with Histologic Grade in Salivary Mucoepidermoid CarcinomaOmar I AhmedLehadh M Al-AzzawiMustafa G Taher Background: Metastasis associated protein-1 (MTA1) has been a recently identified as a unique gene playing important role in tumorigenesis and progression of cancer cells. Objective:To evaluate MTA1 expression and its predictive value in determining histologic grade of salivary mucoepidermoid carcinoma (MEC). Patients and Methods: MTA1 expression was evaluated by immunohistochemistry in paraffin-embedded tumor specimens blocks from 22 patients. Assessment of MTA1 immunostaining was achieved by counting the proportion of positively-stained tumor cells in 5 high power microscopic fields; and staining was analyzed in relation to clinicopathological variables. Results: MTA1 show nuclear and cytoplasmic expression in varying intensity in 95% of cases. No significant correlation was found between MTA1expression and age, gender, site of the tumor (p>0.05). However, statistically significant correlation was found between MTA1expression and clinical stage, nodal involvement (p=0.009 and 0.007; respectively). Regarding histologic grade, high MTA1 level was significantly associated with grade of tumors categorized by Auclair and Brandwein systems (<0.001 and 0.009; respectively). Conclusion:MTA1 expression significantly correlates with tumor grade and progression, and has a potential role in diagnosis and prediction of behavior in salivary MEC. http://djm.uodiyala.edu.iq/index.php/djm/article/view/193Salivary mucoepidermoid carcinoma, MTA1, Tumor grade, Metastasis. |
| spellingShingle | Omar I Ahmed Lehadh M Al-Azzawi Mustafa G Taher MTA1 Expression Correlates Significantly with Histologic Grade in Salivary Mucoepidermoid Carcinoma Diyala Journal of Medicine Salivary mucoepidermoid carcinoma, MTA1, Tumor grade, Metastasis. |
| title | MTA1 Expression Correlates Significantly with Histologic Grade in Salivary Mucoepidermoid Carcinoma |
| title_full | MTA1 Expression Correlates Significantly with Histologic Grade in Salivary Mucoepidermoid Carcinoma |
| title_fullStr | MTA1 Expression Correlates Significantly with Histologic Grade in Salivary Mucoepidermoid Carcinoma |
| title_full_unstemmed | MTA1 Expression Correlates Significantly with Histologic Grade in Salivary Mucoepidermoid Carcinoma |
| title_short | MTA1 Expression Correlates Significantly with Histologic Grade in Salivary Mucoepidermoid Carcinoma |
| title_sort | mta1 expression correlates significantly with histologic grade in salivary mucoepidermoid carcinoma |
| topic | Salivary mucoepidermoid carcinoma, MTA1, Tumor grade, Metastasis. |
| url | http://djm.uodiyala.edu.iq/index.php/djm/article/view/193 |
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