Fat Oxidation Kinetics Is Related to Muscle Deoxygenation Kinetics During Exercise
PurposeThe present study aimed to determine whether whole-body fat oxidation and muscle deoxygenation kinetics parameters during exercise were related in individuals with different aerobic fitness levels.MethodsEleven cyclists [peak oxygen uptake (V.O2peak): 64.9 ± 3.9 mL⋅kg–1⋅min–1] and 11 acti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00571/full |
| _version_ | 1798044653189070848 |
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| author | Anouck Zurbuchen Stefano Lanzi Stefano Lanzi Ludovic Voirol Cybele Barboza Trindade Boris Gojanovic Bengt Kayser Nicolas Bourdillon Xavier Chenevière Davide Malatesta |
| author_facet | Anouck Zurbuchen Stefano Lanzi Stefano Lanzi Ludovic Voirol Cybele Barboza Trindade Boris Gojanovic Bengt Kayser Nicolas Bourdillon Xavier Chenevière Davide Malatesta |
| author_sort | Anouck Zurbuchen |
| collection | DOAJ |
| description | PurposeThe present study aimed to determine whether whole-body fat oxidation and muscle deoxygenation kinetics parameters during exercise were related in individuals with different aerobic fitness levels.MethodsEleven cyclists [peak oxygen uptake (V.O2peak): 64.9 ± 3.9 mL⋅kg–1⋅min–1] and 11 active individuals (V.O2peak: 49.1 ± 7.4 mL⋅kg–1⋅min–1) performed a maximal incremental cycling test to determine V.O2peak and a submaximal incremental cycling test to assess whole-body fat oxidation using indirect calorimetry and muscle deoxygenation kinetics of the vastus lateralis (VL) using near-infrared spectroscopy (NIRS). A sinusoidal (SIN) model was used to characterize fat oxidation kinetics and to determine the intensity (Fatmax) eliciting maximal fat oxidation (MFO). The muscle deoxygenation response was fitted with a double linear model. The slope of the first parts of the kinetics (a1) and the breakpoint ([HHb]BP) were determined.ResultsMFO (p = 0.01) and absolute fat oxidation rates between 20 and 65% V.O2peak were higher in cyclists than in active participants (p < 0.05), while Fatmax occurred at a higher absolute exercise intensity (p = 0.01). a1 was lower in cyclists (p = 0.02) and [HHb]BP occurred at a higher absolute intensity (p < 0.001) than in active individuals. V.O2peak was strongly correlated with MFO, Fatmax, and [HHb]BP (r = 0.65–0.88, p ≤ 0.001). MFO and Fatmax were both correlated with [HHb]BP (r = 0.66, p = 0.01 and r = 0.68, p < 0.001, respectively) and tended to be negatively correlated with a1 (r = -0.41, p = 0.06 for both).ConclusionThis study showed that whole-body fat oxidation and muscle deoxygenation kinetics were both related to aerobic fitness and that a relationship between the two kinetics exists. Individuals with greater aerobic fitness may have a delayed reliance on glycolytic metabolism at higher exercise intensities because of a longer maintained balance between O2 delivery and consumption supporting higher fat oxidation rates. |
| first_indexed | 2024-04-11T23:07:44Z |
| format | Article |
| id | doaj.art-947c22d93682474d92bcb84e65b80c46 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-11T23:07:44Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-947c22d93682474d92bcb84e65b80c462022-12-22T03:57:57ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-06-011110.3389/fphys.2020.00571529179Fat Oxidation Kinetics Is Related to Muscle Deoxygenation Kinetics During ExerciseAnouck Zurbuchen0Stefano Lanzi1Stefano Lanzi2Ludovic Voirol3Cybele Barboza Trindade4Boris Gojanovic5Bengt Kayser6Nicolas Bourdillon7Xavier Chenevière8Davide Malatesta9Department of Neurosciences and Movement Science, Faculty of Science and Medicine, University of Fribourg, Fribourg, SwitzerlandInstitute of Sport Sciences of the University of Lausanne, Doctrine Selon Convention SSP-FBM, University of Lausanne, Lausanne, SwitzerlandDivision of Angiology, Heart and Vessel Department, Lausanne University Hospital, Lausanne, SwitzerlandInstitute of Sport Sciences of the University of Lausanne, Doctrine Selon Convention SSP-FBM, University of Lausanne, Lausanne, SwitzerlandInstitute of Sport Sciences of the University of Lausanne, Doctrine Selon Convention SSP-FBM, University of Lausanne, Lausanne, SwitzerlandSports Medicine Unit, Swiss Olympic Medical Center, Department for Locomotion, Lausanne University Hospital, Lausanne, SwitzerlandInstitute of Sport Sciences of the University of Lausanne, Doctrine Selon Convention SSP-FBM, University of Lausanne, Lausanne, SwitzerlandInstitute of Sport Sciences of the University of Lausanne, Doctrine Selon Convention SSP-FBM, University of Lausanne, Lausanne, SwitzerlandDepartment of Neurosciences and Movement Science, Faculty of Science and Medicine, University of Fribourg, Fribourg, SwitzerlandInstitute of Sport Sciences of the University of Lausanne, Doctrine Selon Convention SSP-FBM, University of Lausanne, Lausanne, SwitzerlandPurposeThe present study aimed to determine whether whole-body fat oxidation and muscle deoxygenation kinetics parameters during exercise were related in individuals with different aerobic fitness levels.MethodsEleven cyclists [peak oxygen uptake (V.O2peak): 64.9 ± 3.9 mL⋅kg–1⋅min–1] and 11 active individuals (V.O2peak: 49.1 ± 7.4 mL⋅kg–1⋅min–1) performed a maximal incremental cycling test to determine V.O2peak and a submaximal incremental cycling test to assess whole-body fat oxidation using indirect calorimetry and muscle deoxygenation kinetics of the vastus lateralis (VL) using near-infrared spectroscopy (NIRS). A sinusoidal (SIN) model was used to characterize fat oxidation kinetics and to determine the intensity (Fatmax) eliciting maximal fat oxidation (MFO). The muscle deoxygenation response was fitted with a double linear model. The slope of the first parts of the kinetics (a1) and the breakpoint ([HHb]BP) were determined.ResultsMFO (p = 0.01) and absolute fat oxidation rates between 20 and 65% V.O2peak were higher in cyclists than in active participants (p < 0.05), while Fatmax occurred at a higher absolute exercise intensity (p = 0.01). a1 was lower in cyclists (p = 0.02) and [HHb]BP occurred at a higher absolute intensity (p < 0.001) than in active individuals. V.O2peak was strongly correlated with MFO, Fatmax, and [HHb]BP (r = 0.65–0.88, p ≤ 0.001). MFO and Fatmax were both correlated with [HHb]BP (r = 0.66, p = 0.01 and r = 0.68, p < 0.001, respectively) and tended to be negatively correlated with a1 (r = -0.41, p = 0.06 for both).ConclusionThis study showed that whole-body fat oxidation and muscle deoxygenation kinetics were both related to aerobic fitness and that a relationship between the two kinetics exists. Individuals with greater aerobic fitness may have a delayed reliance on glycolytic metabolism at higher exercise intensities because of a longer maintained balance between O2 delivery and consumption supporting higher fat oxidation rates.https://www.frontiersin.org/article/10.3389/fphys.2020.00571/fullaerobic fitnesscyclingindirect calorimetryFatmaxNIRSbreaking point |
| spellingShingle | Anouck Zurbuchen Stefano Lanzi Stefano Lanzi Ludovic Voirol Cybele Barboza Trindade Boris Gojanovic Bengt Kayser Nicolas Bourdillon Xavier Chenevière Davide Malatesta Fat Oxidation Kinetics Is Related to Muscle Deoxygenation Kinetics During Exercise Frontiers in Physiology aerobic fitness cycling indirect calorimetry Fatmax NIRS breaking point |
| title | Fat Oxidation Kinetics Is Related to Muscle Deoxygenation Kinetics During Exercise |
| title_full | Fat Oxidation Kinetics Is Related to Muscle Deoxygenation Kinetics During Exercise |
| title_fullStr | Fat Oxidation Kinetics Is Related to Muscle Deoxygenation Kinetics During Exercise |
| title_full_unstemmed | Fat Oxidation Kinetics Is Related to Muscle Deoxygenation Kinetics During Exercise |
| title_short | Fat Oxidation Kinetics Is Related to Muscle Deoxygenation Kinetics During Exercise |
| title_sort | fat oxidation kinetics is related to muscle deoxygenation kinetics during exercise |
| topic | aerobic fitness cycling indirect calorimetry Fatmax NIRS breaking point |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00571/full |
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