An Unusual Case of Severe Persistent Neonatal Thrombocytopenia in an Extremely Low Birth Weight, Extreme Preterm Neonate
Neonatal thrombocytopenia is a common hematological problem but refractory thrombocytopenia is very rare in neonates. A systematic and diligent workup will result in arriving at the proper diagnosis and providing accurate management in rare causes of neonatal thrombocytopenia. We report a case of se...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-08-01
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| Series: | Global Pediatric Health |
| Online Access: | https://doi.org/10.1177/2333794X211038724 |
| _version_ | 1818443619871227904 |
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| author | Mobin Paul MBBS, MD, DM Ananthen Killikulangara Sadanandan MBBS, MD, Fellow in Neonatology Latha Abraham MBBS, MD Sophy Madany Pathrose MBBS Dasary Varghese MBBS |
| author_facet | Mobin Paul MBBS, MD, DM Ananthen Killikulangara Sadanandan MBBS, MD, Fellow in Neonatology Latha Abraham MBBS, MD Sophy Madany Pathrose MBBS Dasary Varghese MBBS |
| author_sort | Mobin Paul MBBS, MD, DM |
| collection | DOAJ |
| description | Neonatal thrombocytopenia is a common hematological problem but refractory thrombocytopenia is very rare in neonates. A systematic and diligent workup will result in arriving at the proper diagnosis and providing accurate management in rare causes of neonatal thrombocytopenia. We report a case of severe refractory thrombocytopenia in an extremely low birth weight (ELBW)/extreme preterm baby who presented with early onset severe thrombocytopenia associated with anemia and required multiple platelet transfusions. After ruling out COVID-19 infection, sepsis and neonatal alloimmune thrombocytopenia (NAIT), the cause for severe refractory thrombocytopenia was diagnosed as Type II congenital amegakaryocytic thrombocytopenia (CAMT) by bone marrow examination and MPL gene mutation studies. |
| first_indexed | 2024-12-14T19:02:56Z |
| format | Article |
| id | doaj.art-947ef4a39f18498aadc81a23649c9cda |
| institution | Directory Open Access Journal |
| issn | 2333-794X |
| language | English |
| last_indexed | 2024-12-14T19:02:56Z |
| publishDate | 2021-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Global Pediatric Health |
| spelling | doaj.art-947ef4a39f18498aadc81a23649c9cda2022-12-21T22:50:54ZengSAGE PublishingGlobal Pediatric Health2333-794X2021-08-01810.1177/2333794X211038724An Unusual Case of Severe Persistent Neonatal Thrombocytopenia in an Extremely Low Birth Weight, Extreme Preterm NeonateMobin Paul MBBS, MD, DM0Ananthen Killikulangara Sadanandan MBBS, MD, Fellow in Neonatology1Latha Abraham MBBS, MD2Sophy Madany Pathrose MBBS3Dasary Varghese MBBS4Rajagiri Hospital, Aluva, Kerala, IndiaKinder Women’s Hospital & Infertility Centre Pvt Ltd, Cherthala, Kerala, IndiaRajagiri Hospital, Aluva, Kerala, IndiaRajagiri Hospital, Aluva, Kerala, IndiaRajagiri Hospital, Aluva, Kerala, IndiaNeonatal thrombocytopenia is a common hematological problem but refractory thrombocytopenia is very rare in neonates. A systematic and diligent workup will result in arriving at the proper diagnosis and providing accurate management in rare causes of neonatal thrombocytopenia. We report a case of severe refractory thrombocytopenia in an extremely low birth weight (ELBW)/extreme preterm baby who presented with early onset severe thrombocytopenia associated with anemia and required multiple platelet transfusions. After ruling out COVID-19 infection, sepsis and neonatal alloimmune thrombocytopenia (NAIT), the cause for severe refractory thrombocytopenia was diagnosed as Type II congenital amegakaryocytic thrombocytopenia (CAMT) by bone marrow examination and MPL gene mutation studies.https://doi.org/10.1177/2333794X211038724 |
| spellingShingle | Mobin Paul MBBS, MD, DM Ananthen Killikulangara Sadanandan MBBS, MD, Fellow in Neonatology Latha Abraham MBBS, MD Sophy Madany Pathrose MBBS Dasary Varghese MBBS An Unusual Case of Severe Persistent Neonatal Thrombocytopenia in an Extremely Low Birth Weight, Extreme Preterm Neonate Global Pediatric Health |
| title | An Unusual Case of Severe Persistent Neonatal Thrombocytopenia in an Extremely Low Birth Weight, Extreme Preterm Neonate |
| title_full | An Unusual Case of Severe Persistent Neonatal Thrombocytopenia in an Extremely Low Birth Weight, Extreme Preterm Neonate |
| title_fullStr | An Unusual Case of Severe Persistent Neonatal Thrombocytopenia in an Extremely Low Birth Weight, Extreme Preterm Neonate |
| title_full_unstemmed | An Unusual Case of Severe Persistent Neonatal Thrombocytopenia in an Extremely Low Birth Weight, Extreme Preterm Neonate |
| title_short | An Unusual Case of Severe Persistent Neonatal Thrombocytopenia in an Extremely Low Birth Weight, Extreme Preterm Neonate |
| title_sort | unusual case of severe persistent neonatal thrombocytopenia in an extremely low birth weight extreme preterm neonate |
| url | https://doi.org/10.1177/2333794X211038724 |
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