Accelerometer-derived physical activity and sedentary time and cardiac biomarkers: The Maastricht Study
BackgroundCardiac troponins and NT-proBNP are biomarkers of cardiac injury that are used clinically in the diagnosis of myocardial infarction and heart failure. It is not known whether the amount, types and patterns of physical activity (PA) and sedentary behaviour are associated with levels of card...
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1081713/full |
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| author | E. J. Vandercappellen E. J. Vandercappellen E. J. Vandercappellen A. Koster A. Koster H. H. C. M. Savelberg H. H. C. M. Savelberg S. J. P. M. Eussen S. J. P. M. Eussen S. J. P. M. Eussen P. C. Dagnelie P. C. Dagnelie M. T. Schram M. T. Schram M. T. Schram M. M. J. van Greevenbroek M. M. J. van Greevenbroek A. Wesselius J. P. Kooman J. P. Kooman A. A. Kroon A. A. Kroon A. A. Kroon R. M. A. Henry R. M. A. Henry R. M. A. Henry C. D. A. Stehouwer C. D. A. Stehouwer |
| author_facet | E. J. Vandercappellen E. J. Vandercappellen E. J. Vandercappellen A. Koster A. Koster H. H. C. M. Savelberg H. H. C. M. Savelberg S. J. P. M. Eussen S. J. P. M. Eussen S. J. P. M. Eussen P. C. Dagnelie P. C. Dagnelie M. T. Schram M. T. Schram M. T. Schram M. M. J. van Greevenbroek M. M. J. van Greevenbroek A. Wesselius J. P. Kooman J. P. Kooman A. A. Kroon A. A. Kroon A. A. Kroon R. M. A. Henry R. M. A. Henry R. M. A. Henry C. D. A. Stehouwer C. D. A. Stehouwer |
| author_sort | E. J. Vandercappellen |
| collection | DOAJ |
| description | BackgroundCardiac troponins and NT-proBNP are biomarkers of cardiac injury that are used clinically in the diagnosis of myocardial infarction and heart failure. It is not known whether the amount, types and patterns of physical activity (PA) and sedentary behaviour are associated with levels of cardiac biomarkers.MethodsIn the population-based Maastricht Study (n = 2,370, 51.3% male, 28.3% T2D) we determined cardiac biomarkers hs-cTnI, hs-cTnT, and NT-proBNP. PA and sedentary time were measured by activPAL and divided into quartiles [quartile 1 (Q1) served as reference]. The weekly pattern of moderate-to-vigorous PA (insufficiently active; regularly actives; weekend warriors) and coefficient of variation (CV) was calculated. Linear regression analyses were conducted with adjustment for demographic, lifestyle, and cardiovascular risk factors.ResultsThere was no consistent pattern between physical activity (different intensities: total, light, moderate-to-vigorous and vigorous) and sedentary time on the one hand and hs-cTnI and hs-cTnT on the other. Those with the highest levels of vigorous intensity PA had significantly lower levels of NT-proBNP. With regard to PA patterns, weekend warriors and regularly actives had lower levels of NT-proBNP but not with hs-cTnI and hs-cTnT (reference:insufficiently actives). A higher weekly moderate-to-vigorous PA CV (indicating more irregular activity) was associated with lower levels of hs-cTnI and higher levels of NT-proBNP, but not with hs-cTnT.ConclusionsIn general, there was no consistent association between PA and sedentary time and cardiac troponins. In contrast, vigorous and possibly moderate-to-vigorous intensity PA, especially if done regularly, were associated with lower levels of NT-proBNP. |
| first_indexed | 2024-04-09T15:33:29Z |
| format | Article |
| id | doaj.art-947fd838e35542b0b436aa169ce5ad62 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-09T15:33:29Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-947fd838e35542b0b436aa169ce5ad622023-04-28T04:45:41ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-04-011010.3389/fcvm.2023.10817131081713Accelerometer-derived physical activity and sedentary time and cardiac biomarkers: The Maastricht StudyE. J. Vandercappellen0E. J. Vandercappellen1E. J. Vandercappellen2A. Koster3A. Koster4H. H. C. M. Savelberg5H. H. C. M. Savelberg6S. J. P. M. Eussen7S. J. P. M. Eussen8S. J. P. M. Eussen9P. C. Dagnelie10P. C. Dagnelie11M. T. Schram12M. T. Schram13M. T. Schram14M. M. J. van Greevenbroek15M. M. J. van Greevenbroek16A. Wesselius17J. P. Kooman18J. P. Kooman19A. A. Kroon20A. A. Kroon21A. A. Kroon22R. M. A. Henry23R. M. A. Henry24R. M. A. Henry25C. D. A. Stehouwer26C. D. A. Stehouwer27Department of Internal Medicine, Maastricht University Medical Center+, Maastricht, The NetherlandsCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The NetherlandsCAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The NetherlandsCAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The NetherlandsDepartment of Social Medicine, Maastricht University, Maastricht, The NetherlandsDepartment of Nutrition and Movement Science, Maastricht University, Maastricht, The NetherlandsNUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The NetherlandsCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The NetherlandsCAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The NetherlandsDepartment of Epidemiology, Maastricht University, Maastricht, The NetherlandsDepartment of Internal Medicine, Maastricht University Medical Center+, Maastricht, The NetherlandsCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The NetherlandsDepartment of Internal Medicine, Maastricht University Medical Center+, Maastricht, The NetherlandsCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The NetherlandsHeart and Vascular Center, Maastricht University Medical Center+, Maastricht, The NetherlandsDepartment of Internal Medicine, Maastricht University Medical Center+, Maastricht, The NetherlandsCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The NetherlandsDepartment of Epidemiology, Maastricht University, Maastricht, The NetherlandsDepartment of Internal Medicine, Maastricht University Medical Center+, Maastricht, The NetherlandsNUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The NetherlandsDepartment of Internal Medicine, Maastricht University Medical Center+, Maastricht, The NetherlandsCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The NetherlandsHeart and Vascular Center, Maastricht University Medical Center+, Maastricht, The NetherlandsDepartment of Internal Medicine, Maastricht University Medical Center+, Maastricht, The NetherlandsCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The NetherlandsHeart and Vascular Center, Maastricht University Medical Center+, Maastricht, The NetherlandsDepartment of Internal Medicine, Maastricht University Medical Center+, Maastricht, The NetherlandsCARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The NetherlandsBackgroundCardiac troponins and NT-proBNP are biomarkers of cardiac injury that are used clinically in the diagnosis of myocardial infarction and heart failure. It is not known whether the amount, types and patterns of physical activity (PA) and sedentary behaviour are associated with levels of cardiac biomarkers.MethodsIn the population-based Maastricht Study (n = 2,370, 51.3% male, 28.3% T2D) we determined cardiac biomarkers hs-cTnI, hs-cTnT, and NT-proBNP. PA and sedentary time were measured by activPAL and divided into quartiles [quartile 1 (Q1) served as reference]. The weekly pattern of moderate-to-vigorous PA (insufficiently active; regularly actives; weekend warriors) and coefficient of variation (CV) was calculated. Linear regression analyses were conducted with adjustment for demographic, lifestyle, and cardiovascular risk factors.ResultsThere was no consistent pattern between physical activity (different intensities: total, light, moderate-to-vigorous and vigorous) and sedentary time on the one hand and hs-cTnI and hs-cTnT on the other. Those with the highest levels of vigorous intensity PA had significantly lower levels of NT-proBNP. With regard to PA patterns, weekend warriors and regularly actives had lower levels of NT-proBNP but not with hs-cTnI and hs-cTnT (reference:insufficiently actives). A higher weekly moderate-to-vigorous PA CV (indicating more irregular activity) was associated with lower levels of hs-cTnI and higher levels of NT-proBNP, but not with hs-cTnT.ConclusionsIn general, there was no consistent association between PA and sedentary time and cardiac troponins. In contrast, vigorous and possibly moderate-to-vigorous intensity PA, especially if done regularly, were associated with lower levels of NT-proBNP.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1081713/fullphysical activitysedentary timecardiac biomarkerscardiac injurytype 2 diabetes |
| spellingShingle | E. J. Vandercappellen E. J. Vandercappellen E. J. Vandercappellen A. Koster A. Koster H. H. C. M. Savelberg H. H. C. M. Savelberg S. J. P. M. Eussen S. J. P. M. Eussen S. J. P. M. Eussen P. C. Dagnelie P. C. Dagnelie M. T. Schram M. T. Schram M. T. Schram M. M. J. van Greevenbroek M. M. J. van Greevenbroek A. Wesselius J. P. Kooman J. P. Kooman A. A. Kroon A. A. Kroon A. A. Kroon R. M. A. Henry R. M. A. Henry R. M. A. Henry C. D. A. Stehouwer C. D. A. Stehouwer Accelerometer-derived physical activity and sedentary time and cardiac biomarkers: The Maastricht Study Frontiers in Cardiovascular Medicine physical activity sedentary time cardiac biomarkers cardiac injury type 2 diabetes |
| title | Accelerometer-derived physical activity and sedentary time and cardiac biomarkers: The Maastricht Study |
| title_full | Accelerometer-derived physical activity and sedentary time and cardiac biomarkers: The Maastricht Study |
| title_fullStr | Accelerometer-derived physical activity and sedentary time and cardiac biomarkers: The Maastricht Study |
| title_full_unstemmed | Accelerometer-derived physical activity and sedentary time and cardiac biomarkers: The Maastricht Study |
| title_short | Accelerometer-derived physical activity and sedentary time and cardiac biomarkers: The Maastricht Study |
| title_sort | accelerometer derived physical activity and sedentary time and cardiac biomarkers the maastricht study |
| topic | physical activity sedentary time cardiac biomarkers cardiac injury type 2 diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1081713/full |
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