Dynamics, association, and temporal sequence of cognitive function and frailty: a longitudinal study among Chinese community-dwelling older adults
Abstract Background Little is known about the association of longitudinal dynamics between cognitive function and frailty in Chinese older adults. The temporal sequences between cognitive function and frailty remains unclear. Our study investigates this directionality association using longitudinal...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-023-04328-9 |
| _version_ | 1827708469871902720 |
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| author | Kai Cui Weihan Meng Zhiqiang Li Xinning Zeng Xiaozhe Li Xiaoyan Ge |
| author_facet | Kai Cui Weihan Meng Zhiqiang Li Xinning Zeng Xiaozhe Li Xiaoyan Ge |
| author_sort | Kai Cui |
| collection | DOAJ |
| description | Abstract Background Little is known about the association of longitudinal dynamics between cognitive function and frailty in Chinese older adults. The temporal sequences between cognitive function and frailty remains unclear. Our study investigates this directionality association using longitudinal data. Methods Latent growth and multivariate latent growth models were employed to examine dynamics of cognition and frailty and their association among 2824 older adults in China. Cross-lagged panel analyses were used to assess the temporal sequences between frailty and cognition. The relation between cognitive domains and frailty was also examined using aforementioned methods. Results Cognitive function was negatively associated with frailty status. Higher initial level of cognition indicated lower baseline level (β=-0.175, P < 0.001) and change rate (β=-0.041, P = 0.002) of frailty. We observed a reciprocal association between frailty and cognitive function rather than a unidirectional causal relationship. The initial cognitive performance for all components were negatively associated with baseline (β ranged between − 0.098 to -0.023) and change rate (β ranged between − 0.007 to -0.024) of frail status. No consistent associations between change rate of cognitive components and either initial level or change rate of frailty were detected. Conclusions Our study detected a reciprocal association between cognition and frailty rather than a unidirectional causal relationship. Our results also revealed different connections between cognitive performance and frailty across diverse cognitive domains. |
| first_indexed | 2024-03-10T17:05:05Z |
| format | Article |
| id | doaj.art-94806210709542f5b91962becf8e30ed |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-03-10T17:05:05Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-94806210709542f5b91962becf8e30ed2023-11-20T10:51:21ZengBMCBMC Geriatrics1471-23182023-10-012311910.1186/s12877-023-04328-9Dynamics, association, and temporal sequence of cognitive function and frailty: a longitudinal study among Chinese community-dwelling older adultsKai Cui0Weihan Meng1Zhiqiang Li2Xinning Zeng3Xiaozhe Li4Xiaoyan Ge5School of Public Health, Jinzhou Medical UniversitySchool of Public Health, Jinzhou Medical UniversitySchool of Public Health, Jinzhou Medical UniversitySchool of Public Health, Jinzhou Medical UniversitySchool of Public Health, Jinzhou Medical UniversitySchool of Public Health, Jinzhou Medical UniversityAbstract Background Little is known about the association of longitudinal dynamics between cognitive function and frailty in Chinese older adults. The temporal sequences between cognitive function and frailty remains unclear. Our study investigates this directionality association using longitudinal data. Methods Latent growth and multivariate latent growth models were employed to examine dynamics of cognition and frailty and their association among 2824 older adults in China. Cross-lagged panel analyses were used to assess the temporal sequences between frailty and cognition. The relation between cognitive domains and frailty was also examined using aforementioned methods. Results Cognitive function was negatively associated with frailty status. Higher initial level of cognition indicated lower baseline level (β=-0.175, P < 0.001) and change rate (β=-0.041, P = 0.002) of frailty. We observed a reciprocal association between frailty and cognitive function rather than a unidirectional causal relationship. The initial cognitive performance for all components were negatively associated with baseline (β ranged between − 0.098 to -0.023) and change rate (β ranged between − 0.007 to -0.024) of frail status. No consistent associations between change rate of cognitive components and either initial level or change rate of frailty were detected. Conclusions Our study detected a reciprocal association between cognition and frailty rather than a unidirectional causal relationship. Our results also revealed different connections between cognitive performance and frailty across diverse cognitive domains.https://doi.org/10.1186/s12877-023-04328-9CognitionFrailtyTemporal sequenceCognitive domain |
| spellingShingle | Kai Cui Weihan Meng Zhiqiang Li Xinning Zeng Xiaozhe Li Xiaoyan Ge Dynamics, association, and temporal sequence of cognitive function and frailty: a longitudinal study among Chinese community-dwelling older adults BMC Geriatrics Cognition Frailty Temporal sequence Cognitive domain |
| title | Dynamics, association, and temporal sequence of cognitive function and frailty: a longitudinal study among Chinese community-dwelling older adults |
| title_full | Dynamics, association, and temporal sequence of cognitive function and frailty: a longitudinal study among Chinese community-dwelling older adults |
| title_fullStr | Dynamics, association, and temporal sequence of cognitive function and frailty: a longitudinal study among Chinese community-dwelling older adults |
| title_full_unstemmed | Dynamics, association, and temporal sequence of cognitive function and frailty: a longitudinal study among Chinese community-dwelling older adults |
| title_short | Dynamics, association, and temporal sequence of cognitive function and frailty: a longitudinal study among Chinese community-dwelling older adults |
| title_sort | dynamics association and temporal sequence of cognitive function and frailty a longitudinal study among chinese community dwelling older adults |
| topic | Cognition Frailty Temporal sequence Cognitive domain |
| url | https://doi.org/10.1186/s12877-023-04328-9 |
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