Re-Emergence of Minimal Residual Disease Detected by Flow Cytometry Predicts an Adverse Outcome in Pediatric Acute Lymphoblastic Leukemia

Re-Emergence of Minimal Residual Disease Detected by Flow Cytometry Predicts an Adverse Outcome in Pediatric Acute Lymphoblastic Leukemia

PurposeWhile the role of minimal residual disease (MRD) assessment and the significance of achieving an MRD-negative status during treatment have been evaluated in previous studies, there is limited evidence on the significance of MRD re-emergence without morphological relapse in acute lymphoblastic...

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Bibliographic Details
Main Authors: Yu Wang, Yu-Juan Xue, Yue-Ping Jia, Ying-Xi Zuo, Ai-Dong Lu, Le-Ping Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
acute lymphoblastic leukemia
pediatric
minimal residual disease
re-emergence
hematopoietic cell transplantation (HSCT)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.596677/full

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