Endoscopy for assessment of mucosal healing in ulcerative colitis: time bound or response guided?
The timing of colonoscopy in patients with active ulcerative colitis (UC) lacks coherence. The published guidelines and recommendations advocate time-bound colonoscopy in patients with active UC to assess for mucosal healing. However, the practice of performing colonoscopies at fixed time frames lac...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Association for the Study of Intestinal Diseases
2022-07-01
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| Series: | Intestinal Research |
| Subjects: | |
| Online Access: | http://irjournal.org/upload/pdf/ir-2021-00099.pdf |
| _version_ | 1818013625251528704 |
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| author | Ajit Sood Ramit Mahajan Arshdeep Singh Vandana Midha Varun Mehta |
| author_facet | Ajit Sood Ramit Mahajan Arshdeep Singh Vandana Midha Varun Mehta |
| author_sort | Ajit Sood |
| collection | DOAJ |
| description | The timing of colonoscopy in patients with active ulcerative colitis (UC) lacks coherence. The published guidelines and recommendations advocate time-bound colonoscopy in patients with active UC to assess for mucosal healing. However, the practice of performing colonoscopies at fixed time frames lacks reasoning. The time to achieve mucosal healing in UC is not uniform across the patient populations and is influenced by the disease severity and efficacy and time to therapeutic response of the drugs being used. Additionally, with the availability of sensitive noninvasive inflammatory biomarkers such as fecal calprotectin, that parallel the disease activity and correlate with mucosal healing, the notion of performing colonoscopy at fixed intervals sounds unjustifiable. The authors express their view that a response-guided colonoscopy (driven by normalization of clinical symptoms and inflammatory biomarkers), rather than a time-bound colonoscopy, would be more logical, apart from being cost-effective and patient-friendly. |
| first_indexed | 2024-04-14T06:35:36Z |
| format | Article |
| id | doaj.art-94835f9a09ef4af691dc097e096a82d6 |
| institution | Directory Open Access Journal |
| issn | 1598-9100 2288-1956 |
| language | English |
| last_indexed | 2024-04-14T06:35:36Z |
| publishDate | 2022-07-01 |
| publisher | Korean Association for the Study of Intestinal Diseases |
| record_format | Article |
| series | Intestinal Research |
| spelling | doaj.art-94835f9a09ef4af691dc097e096a82d62022-12-22T02:07:28ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002288-19562022-07-0120329730210.5217/ir.2021.00099941Endoscopy for assessment of mucosal healing in ulcerative colitis: time bound or response guided?Ajit Sood0Ramit Mahajan1Arshdeep Singh2Vandana Midha3Varun Mehta4 Department of Gastroenterology, Dayanand Medical College, Ludhiana, India Department of Gastroenterology, Dayanand Medical College, Ludhiana, India Department of Gastroenterology, Dayanand Medical College, Ludhiana, India Department of Internal Medicine, Dayanand Medical College, Ludhiana, India Department of Gastroenterology, Dayanand Medical College, Ludhiana, IndiaThe timing of colonoscopy in patients with active ulcerative colitis (UC) lacks coherence. The published guidelines and recommendations advocate time-bound colonoscopy in patients with active UC to assess for mucosal healing. However, the practice of performing colonoscopies at fixed time frames lacks reasoning. The time to achieve mucosal healing in UC is not uniform across the patient populations and is influenced by the disease severity and efficacy and time to therapeutic response of the drugs being used. Additionally, with the availability of sensitive noninvasive inflammatory biomarkers such as fecal calprotectin, that parallel the disease activity and correlate with mucosal healing, the notion of performing colonoscopy at fixed intervals sounds unjustifiable. The authors express their view that a response-guided colonoscopy (driven by normalization of clinical symptoms and inflammatory biomarkers), rather than a time-bound colonoscopy, would be more logical, apart from being cost-effective and patient-friendly.http://irjournal.org/upload/pdf/ir-2021-00099.pdfcolitis, ulcerativecolonoscopyfecal calprotectin |
| spellingShingle | Ajit Sood Ramit Mahajan Arshdeep Singh Vandana Midha Varun Mehta Endoscopy for assessment of mucosal healing in ulcerative colitis: time bound or response guided? Intestinal Research colitis, ulcerative colonoscopy fecal calprotectin |
| title | Endoscopy for assessment of mucosal healing in ulcerative colitis: time bound or response guided? |
| title_full | Endoscopy for assessment of mucosal healing in ulcerative colitis: time bound or response guided? |
| title_fullStr | Endoscopy for assessment of mucosal healing in ulcerative colitis: time bound or response guided? |
| title_full_unstemmed | Endoscopy for assessment of mucosal healing in ulcerative colitis: time bound or response guided? |
| title_short | Endoscopy for assessment of mucosal healing in ulcerative colitis: time bound or response guided? |
| title_sort | endoscopy for assessment of mucosal healing in ulcerative colitis time bound or response guided |
| topic | colitis, ulcerative colonoscopy fecal calprotectin |
| url | http://irjournal.org/upload/pdf/ir-2021-00099.pdf |
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