Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

The molecular chaperone Hsp90 protects deregulated signaling proteins that are vital for tumor growth and survival. Tumors generally display sensitivity and selectivity toward Hsp90 inhibitors; however, the molecular mechanism underlying this phenotype remains undefined. We report that the mitotic c...

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Bibliographic Details
Main Authors: Mark R. Woodford, Andrew W. Truman, Diana M. Dunn, Sandra M. Jensen, Richard Cotran, Renee Bullard, Mourad Abouelleil, Kristin Beebe, Donald Wolfgeher, Sara Wierzbicki, Dawn E. Post, Tiffany Caza, Shinji Tsutsumi, Barry Panaretou, Stephen J. Kron, Jane B. Trepel, Steve Landas, Chrisostomos Prodromou, Oleg Shapiro, William G. Stetler-Stevenson, Dimitra Bourboulia, Len Neckers, Gennady Bratslavsky, Mehdi Mollapour
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Cell Reports
Subjects:
heat shock protein-90
phosphorylation
kinase
phosphatase
molecular chaperones
mitotic checkpoint
Mps1
Cdc14
renal cell carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715015405

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