Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity
An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investigated. Among them, an isochromene with moderate ac...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/17/8/9621 |
| _version_ | 1818035304590737408 |
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| author | Kachi R. Kishore Kumar Reddy Giovanna B. Longato João E. de Carvalho Ana L. T. G. Ruiz Luiz F. Silva, Jr. |
| author_facet | Kachi R. Kishore Kumar Reddy Giovanna B. Longato João E. de Carvalho Ana L. T. G. Ruiz Luiz F. Silva, Jr. |
| author_sort | Kachi R. Kishore Kumar Reddy |
| collection | DOAJ |
| description | An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investigated. Among them, an isochromene with moderate activity (mean logGI<sub>50</sub> = 0.91) was found. Additionally, compounds with selectivity toward the tumor cell lines NCI-ADR/RES, OVCAR-3, and HT29 were discovered. |
| first_indexed | 2024-12-10T06:52:56Z |
| format | Article |
| id | doaj.art-9484a12b3f8e4f00be0cef79a09d5e5d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T06:52:56Z |
| publishDate | 2012-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9484a12b3f8e4f00be0cef79a09d5e5d2022-12-22T01:58:30ZengMDPI AGMolecules1420-30492012-08-011789621963010.3390/molecules17089621Populene D Analogues: Design, Concise Synthesis and Antiproliferative ActivityKachi R. Kishore Kumar ReddyGiovanna B. LongatoJoão E. de CarvalhoAna L. T. G. RuizLuiz F. Silva, Jr.An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investigated. Among them, an isochromene with moderate activity (mean logGI<sub>50</sub> = 0.91) was found. Additionally, compounds with selectivity toward the tumor cell lines NCI-ADR/RES, OVCAR-3, and HT29 were discovered.http://www.mdpi.com/1420-3049/17/8/9621osochromenepyransPrins cyclizationiodineantiproliferativecancer |
| spellingShingle | Kachi R. Kishore Kumar Reddy Giovanna B. Longato João E. de Carvalho Ana L. T. G. Ruiz Luiz F. Silva, Jr. Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity Molecules osochromene pyrans Prins cyclization iodine antiproliferative cancer |
| title | Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity |
| title_full | Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity |
| title_fullStr | Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity |
| title_full_unstemmed | Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity |
| title_short | Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity |
| title_sort | populene d analogues design concise synthesis and antiproliferative activity |
| topic | osochromene pyrans Prins cyclization iodine antiproliferative cancer |
| url | http://www.mdpi.com/1420-3049/17/8/9621 |
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