Oral function in patients with myasthenia gravis
Myasthenia Gravis (MG) is characterised by muscle weakness and increased fatigability. The aim of this pilot study was to investigate if patients with MG demonstrate different functional chewing patterns and report more complaints related to mastication as compared with healthy controls. Twelve pati...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2021-06-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/11680.pdf |
| _version_ | 1797419714249490432 |
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| author | Agnete Overgaard Donskov Akiko Shimada Lotte Vinge Peter Svensson Henning Andersen |
| author_facet | Agnete Overgaard Donskov Akiko Shimada Lotte Vinge Peter Svensson Henning Andersen |
| author_sort | Agnete Overgaard Donskov |
| collection | DOAJ |
| description | Myasthenia Gravis (MG) is characterised by muscle weakness and increased fatigability. The aim of this pilot study was to investigate if patients with MG demonstrate different functional chewing patterns and report more complaints related to mastication as compared with healthy controls. Twelve patients (median 60 years Q1–Q3: 46–70) with generalised MG and nine healthy controls (median 57 years Q1–Q3: 55–63) participated. All participants underwent dental and oral examination and were asked to fill in a questionnaire concerning oral health. Static maximum bite force was measured with a bite force transducer, electromyography in the masseter, temporalis, and suprahyoid muscles were recorded, and jaw movement was tracked, during a 5-minute gum chewing test. The patients had more oral complaints (oral health impact profile total score 22.6 vs 7.5 P < 0.01) and had lower peak bite force than controls (18.8kgf (11.1;26.4) (95% CI) vs 29.5 kgf (21.6; 37.4) (P = 0.04)). In contrast, fatigability of the masticatory muscles, as defined by number of chewing cycles during the gum-chewing test, did not differ between patients and controls (P = 0.10). In conclusion, patients had more oral complaints and lower bite force than controls, but did not show significantly different functional chewing patterns. Future studies should aim at integrating measurement of peak force into functional tests. Attention should be given to oral complaints of patients with MG. |
| first_indexed | 2024-03-09T06:51:20Z |
| format | Article |
| id | doaj.art-9485fee83107439cac010ecbd6bdcfac |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:51:20Z |
| publishDate | 2021-06-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-9485fee83107439cac010ecbd6bdcfac2023-12-03T10:26:24ZengPeerJ Inc.PeerJ2167-83592021-06-019e1168010.7717/peerj.11680Oral function in patients with myasthenia gravisAgnete Overgaard Donskov0Akiko Shimada1Lotte Vinge2Peter Svensson3Henning Andersen4Department of Neurology, Aarhus University Hospital, Aarhus, Region midt, DenmarkDepartment of Geriatric Dentistry, Osaka Dental University, Osaka, JapanDepartment of Neurology, Aarhus University Hospital, Aarhus, Region midt, DenmarkSection of Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University, DenmarkDepartment of Neurology, Aarhus University Hospital, Aarhus, Region midt, DenmarkMyasthenia Gravis (MG) is characterised by muscle weakness and increased fatigability. The aim of this pilot study was to investigate if patients with MG demonstrate different functional chewing patterns and report more complaints related to mastication as compared with healthy controls. Twelve patients (median 60 years Q1–Q3: 46–70) with generalised MG and nine healthy controls (median 57 years Q1–Q3: 55–63) participated. All participants underwent dental and oral examination and were asked to fill in a questionnaire concerning oral health. Static maximum bite force was measured with a bite force transducer, electromyography in the masseter, temporalis, and suprahyoid muscles were recorded, and jaw movement was tracked, during a 5-minute gum chewing test. The patients had more oral complaints (oral health impact profile total score 22.6 vs 7.5 P < 0.01) and had lower peak bite force than controls (18.8kgf (11.1;26.4) (95% CI) vs 29.5 kgf (21.6; 37.4) (P = 0.04)). In contrast, fatigability of the masticatory muscles, as defined by number of chewing cycles during the gum-chewing test, did not differ between patients and controls (P = 0.10). In conclusion, patients had more oral complaints and lower bite force than controls, but did not show significantly different functional chewing patterns. Future studies should aim at integrating measurement of peak force into functional tests. Attention should be given to oral complaints of patients with MG.https://peerj.com/articles/11680.pdfMyasthenia GravisMasticationOral function |
| spellingShingle | Agnete Overgaard Donskov Akiko Shimada Lotte Vinge Peter Svensson Henning Andersen Oral function in patients with myasthenia gravis PeerJ Myasthenia Gravis Mastication Oral function |
| title | Oral function in patients with myasthenia gravis |
| title_full | Oral function in patients with myasthenia gravis |
| title_fullStr | Oral function in patients with myasthenia gravis |
| title_full_unstemmed | Oral function in patients with myasthenia gravis |
| title_short | Oral function in patients with myasthenia gravis |
| title_sort | oral function in patients with myasthenia gravis |
| topic | Myasthenia Gravis Mastication Oral function |
| url | https://peerj.com/articles/11680.pdf |
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