Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes
Background: The aims of this study were to evaluate the clinical outcomes and their predictive factors in locally advanced hypopharyngeal cancer (HC) patients included in a docetaxel-cisplatin-fluorouracil induction chemotherapy (ICT)-based larynx preservation (LP) program. Methods: Between 2005 and...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/3/1131 |
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| author | Pierre Mattei Jocelyn Gal Emmanuel Chamorey Olivier Dassonville Gilles Poissonnet Déborah Aloi Médéric Barret Inga Safta Esma Saada Anne Sudaka Dorian Culié Alexandre Bozec |
| author_facet | Pierre Mattei Jocelyn Gal Emmanuel Chamorey Olivier Dassonville Gilles Poissonnet Déborah Aloi Médéric Barret Inga Safta Esma Saada Anne Sudaka Dorian Culié Alexandre Bozec |
| author_sort | Pierre Mattei |
| collection | DOAJ |
| description | Background: The aims of this study were to evaluate the clinical outcomes and their predictive factors in locally advanced hypopharyngeal cancer (HC) patients included in a docetaxel-cisplatin-fluorouracil induction chemotherapy (ICT)-based larynx preservation (LP) program. Methods: Between 2005 and 2021, 82 patients with a locally advanced resectable HC who received ICT in an LP program were included in this retrospective study. The predictors of oncologic and swallowing outcomes were determined in univariate and multivariate analyses. Results: The three- and five-year overall survival (OS) rates were 67 and 54%, respectively. The T4 tumor stage was the only predictive factor of poor response to ICT (<i>p</i> = 0.03). In multivariate analysis, a T stage = 4 (<i>p</i> = 0.02), an ICT cycle number < 3 (<i>p</i> = 0.003) and the absence of a response to ICT (<i>p</i> = 0.03) were significantly associated with worse OS. A low body mass index before therapy (<i>p</i> = 0.003) and enteral nutrition during therapy (<i>p</i> = 0.005) were significantly associated with severity of dysphagia 6 months after treatment. Conclusions: The T stage, number of ICT cycles performed and response to ICT are the main predictors of oncologic outcomes. Patients with T4 HC are poor candidates for LP and should be referred to immediate radical surgery. |
| first_indexed | 2024-03-11T09:38:07Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T09:38:07Z |
| publishDate | 2023-02-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-9488642e6acc4671bae5e8bf06c3159f2023-11-16T17:12:12ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01123113110.3390/jcm12031131Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional OutcomesPierre Mattei0Jocelyn Gal1Emmanuel Chamorey2Olivier Dassonville3Gilles Poissonnet4Déborah Aloi5Médéric Barret6Inga Safta7Esma Saada8Anne Sudaka9Dorian Culié10Alexandre Bozec11Institut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, FranceDepartment of Statistics, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, FranceDepartment of Statistics, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, FranceInstitut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, FranceInstitut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, FranceDepartment of Radiation Oncology, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, FranceDepartment of Radiation Oncology, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, FranceDepartment of Medical Oncology, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, FranceDepartment of Medical Oncology, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, FranceDepartment of Pathology, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, FranceInstitut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, FranceInstitut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, FranceBackground: The aims of this study were to evaluate the clinical outcomes and their predictive factors in locally advanced hypopharyngeal cancer (HC) patients included in a docetaxel-cisplatin-fluorouracil induction chemotherapy (ICT)-based larynx preservation (LP) program. Methods: Between 2005 and 2021, 82 patients with a locally advanced resectable HC who received ICT in an LP program were included in this retrospective study. The predictors of oncologic and swallowing outcomes were determined in univariate and multivariate analyses. Results: The three- and five-year overall survival (OS) rates were 67 and 54%, respectively. The T4 tumor stage was the only predictive factor of poor response to ICT (<i>p</i> = 0.03). In multivariate analysis, a T stage = 4 (<i>p</i> = 0.02), an ICT cycle number < 3 (<i>p</i> = 0.003) and the absence of a response to ICT (<i>p</i> = 0.03) were significantly associated with worse OS. A low body mass index before therapy (<i>p</i> = 0.003) and enteral nutrition during therapy (<i>p</i> = 0.005) were significantly associated with severity of dysphagia 6 months after treatment. Conclusions: The T stage, number of ICT cycles performed and response to ICT are the main predictors of oncologic outcomes. Patients with T4 HC are poor candidates for LP and should be referred to immediate radical surgery.https://www.mdpi.com/2077-0383/12/3/1131hypopharyngeal cancerlarynx preservationinduction chemotherapysurvivaldysphagiapredictive factors |
| spellingShingle | Pierre Mattei Jocelyn Gal Emmanuel Chamorey Olivier Dassonville Gilles Poissonnet Déborah Aloi Médéric Barret Inga Safta Esma Saada Anne Sudaka Dorian Culié Alexandre Bozec Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes Journal of Clinical Medicine hypopharyngeal cancer larynx preservation induction chemotherapy survival dysphagia predictive factors |
| title | Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes |
| title_full | Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes |
| title_fullStr | Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes |
| title_full_unstemmed | Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes |
| title_short | Docetaxel-Cisplatin-Fluorouracil Induction Chemotherapy for Larynx Preservation in Patients with Locally Advanced Hypopharyngeal Cancer: Predictive Factors of Oncologic and Functional Outcomes |
| title_sort | docetaxel cisplatin fluorouracil induction chemotherapy for larynx preservation in patients with locally advanced hypopharyngeal cancer predictive factors of oncologic and functional outcomes |
| topic | hypopharyngeal cancer larynx preservation induction chemotherapy survival dysphagia predictive factors |
| url | https://www.mdpi.com/2077-0383/12/3/1131 |
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