Frequency and risk factors for thromboembolic complications in patients with inflammatory bowel diseases
Background. Inflammatory bowel diseases (IBD) are characterized by chronic immune inflammation of the mucous membrane and/or the thickness of the intestinal wall, and are also accompanied by disorders of the blood clotting system and the development of a hypercoagulation state. Aim. To identify t...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2022-02-01
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| Series: | Терапевтический архив |
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| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/105511/79929 |
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| author | Albina A. Lishchinskaya Oleg V. Knyazev Anna V. Kagramanova Galina A. Dudina Elena A. Sabelnikova Irina A. Li Karina K. Noskova Natalia A. Bodunova Asfold I. Parfenov |
| author_facet | Albina A. Lishchinskaya Oleg V. Knyazev Anna V. Kagramanova Galina A. Dudina Elena A. Sabelnikova Irina A. Li Karina K. Noskova Natalia A. Bodunova Asfold I. Parfenov |
| author_sort | Albina A. Lishchinskaya |
| collection | DOAJ |
| description | Background. Inflammatory bowel diseases (IBD) are characterized by chronic immune inflammation of the mucous membrane and/or the thickness of the intestinal wall, and are also accompanied by disorders of the blood clotting system and the development of a hypercoagulation state.
Aim. To identify the frequency of thromboembolic complications (TEC) in IBD patients and to determine the influence of acquired and inherited hypercoagulation factors that contribute to the development of TEС.
Materials and methods. The clinical status of 1,238 IBD patients who were treated in 2019 was evaluated. Of these, 748 patients with ulcerative colitis (UC) and 490 patients with Crohn's disease (CD). Among UC patients, there were 369 (49.3%) men and 379 (50.7%) women. In 10.1% of patients with UC, there were clinically significant feasibility studies. There were 227 (46.3%) men and 263 (53.7%) women among patients with CD; 7.3% of patients with CD had clinically significant feasibility studies.
Results. In general 112 (9.0%) of 1,238 IBD patients had clinically significant feasibility studies. Among patients with UC (n=748), 76 (10.2%) showed clinically significant feasibility studies. Among patients with CD (n=490), 36 (7.3%) had a feasibility study. Of 112 IBD patients with clinically significant TEC, 45 (40.2%) had genetic polymorphisms that increase affinity for fibrinogen, increase platelet aggregation, and contribute to a decrease in the activity of folate cycle enzymes, including methylenetetrahydrofolate reductase, which may be manifested by a moderate increase in homocysteine levels. Of the 45 IBD patients with clinically significant TEC due to inherited factors, 30 (66.6%) patients had UC, 15 (33.7%) patients had CD (hazard ratio 1.038, 95% confidence interval 0.7461.444; 2=0.049; p=0.83921); 67 (59.8%) patients with IBD who had clinically significant TEC did not have genetic polymorphisms leading to hypercoagulation.
Conclusion. Based on the analysis, we can conclude that such risk factors for the development of TEC as the status of a smoker, long bed rest, taking hormonal contraceptives, varicose veins of the lower extremities, high activity of the disease, glucocorticoids therapy, the extent of intestinal damage in patients with IBD, genetic factors, should be taken into account by gastroenterologists in the treatment of patients with UC and CD. The hereditary factor of hypercoagulation equally affects the development of TEC, both in patients with UC and CD. |
| first_indexed | 2024-12-13T19:44:11Z |
| format | Article |
| id | doaj.art-94898a615b6c40caa432237c1ee09ad1 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-13T19:44:11Z |
| publishDate | 2022-02-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-94898a615b6c40caa432237c1ee09ad12022-12-21T23:33:37Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422022-02-0194217217910.26442/00403660.2022.02.20136778060Frequency and risk factors for thromboembolic complications in patients with inflammatory bowel diseasesAlbina A. Lishchinskaya0https://orcid.org/0000-0001-7891-2702Oleg V. Knyazev1https://orcid.org/0000-0001-7250-0977Anna V. Kagramanova2https://orcid.org/0000-0002-3818-6205Galina A. Dudina3https://orcid.org/0000-0001-9673-1067Elena A. Sabelnikova4https://orcid.org/0000-0001-7519-2041Irina A. Li5https://orcid.org/0000-0002-9508-7502Karina K. Noskova6https://orcid.org/0000-0001-5734-0995Natalia A. Bodunova7https://orcid.org/0000-0002-3119-7673Asfold I. Parfenov8https://orcid.org/0000-0002-9782-4860Loginov Moscow Clinical Scientific CenterLoginov Moscow Clinical Scientific CenterLoginov Moscow Clinical Scientific CenterLoginov Moscow Clinical Scientific CenterLoginov Moscow Clinical Scientific CenterLoginov Moscow Clinical Scientific CenterLoginov Moscow Clinical Scientific CenterLoginov Moscow Clinical Scientific CenterLoginov Moscow Clinical Scientific CenterBackground. Inflammatory bowel diseases (IBD) are characterized by chronic immune inflammation of the mucous membrane and/or the thickness of the intestinal wall, and are also accompanied by disorders of the blood clotting system and the development of a hypercoagulation state. Aim. To identify the frequency of thromboembolic complications (TEC) in IBD patients and to determine the influence of acquired and inherited hypercoagulation factors that contribute to the development of TEС. Materials and methods. The clinical status of 1,238 IBD patients who were treated in 2019 was evaluated. Of these, 748 patients with ulcerative colitis (UC) and 490 patients with Crohn's disease (CD). Among UC patients, there were 369 (49.3%) men and 379 (50.7%) women. In 10.1% of patients with UC, there were clinically significant feasibility studies. There were 227 (46.3%) men and 263 (53.7%) women among patients with CD; 7.3% of patients with CD had clinically significant feasibility studies. Results. In general 112 (9.0%) of 1,238 IBD patients had clinically significant feasibility studies. Among patients with UC (n=748), 76 (10.2%) showed clinically significant feasibility studies. Among patients with CD (n=490), 36 (7.3%) had a feasibility study. Of 112 IBD patients with clinically significant TEC, 45 (40.2%) had genetic polymorphisms that increase affinity for fibrinogen, increase platelet aggregation, and contribute to a decrease in the activity of folate cycle enzymes, including methylenetetrahydrofolate reductase, which may be manifested by a moderate increase in homocysteine levels. Of the 45 IBD patients with clinically significant TEC due to inherited factors, 30 (66.6%) patients had UC, 15 (33.7%) patients had CD (hazard ratio 1.038, 95% confidence interval 0.7461.444; 2=0.049; p=0.83921); 67 (59.8%) patients with IBD who had clinically significant TEC did not have genetic polymorphisms leading to hypercoagulation. Conclusion. Based on the analysis, we can conclude that such risk factors for the development of TEC as the status of a smoker, long bed rest, taking hormonal contraceptives, varicose veins of the lower extremities, high activity of the disease, glucocorticoids therapy, the extent of intestinal damage in patients with IBD, genetic factors, should be taken into account by gastroenterologists in the treatment of patients with UC and CD. The hereditary factor of hypercoagulation equally affects the development of TEC, both in patients with UC and CD.https://ter-arkhiv.ru/0040-3660/article/viewFile/105511/79929crohn's diseaseinflammatory bowel diseasethromboembolic complicationsulcerative colitis |
| spellingShingle | Albina A. Lishchinskaya Oleg V. Knyazev Anna V. Kagramanova Galina A. Dudina Elena A. Sabelnikova Irina A. Li Karina K. Noskova Natalia A. Bodunova Asfold I. Parfenov Frequency and risk factors for thromboembolic complications in patients with inflammatory bowel diseases Терапевтический архив crohn's disease inflammatory bowel disease thromboembolic complications ulcerative colitis |
| title | Frequency and risk factors for thromboembolic complications in patients with inflammatory bowel diseases |
| title_full | Frequency and risk factors for thromboembolic complications in patients with inflammatory bowel diseases |
| title_fullStr | Frequency and risk factors for thromboembolic complications in patients with inflammatory bowel diseases |
| title_full_unstemmed | Frequency and risk factors for thromboembolic complications in patients with inflammatory bowel diseases |
| title_short | Frequency and risk factors for thromboembolic complications in patients with inflammatory bowel diseases |
| title_sort | frequency and risk factors for thromboembolic complications in patients with inflammatory bowel diseases |
| topic | crohn's disease inflammatory bowel disease thromboembolic complications ulcerative colitis |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/105511/79929 |
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