Sustainable Extraction Techniques for Obtaining Antioxidant and Anti-Inflammatory Compounds from the Lamiaceae and Asteraceae Species
<i>Melissa officinalis</i> L. and <i>Origanum majorana</i> L., within Lamiaceae family, and <i>Calendula officinalis</i> L. and <i>Achillea millefolium</i> L., within the Asteraceae, have been considered a good source of bioactive ingredients with heal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/9/2067 |
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| author | Marisol Villalva Susana Santoyo Lilia Salas-Pérez María de las Nieves Siles-Sánchez Mónica Rodríguez García-Risco Tiziana Fornari Guillermo Reglero Laura Jaime |
| author_facet | Marisol Villalva Susana Santoyo Lilia Salas-Pérez María de las Nieves Siles-Sánchez Mónica Rodríguez García-Risco Tiziana Fornari Guillermo Reglero Laura Jaime |
| author_sort | Marisol Villalva |
| collection | DOAJ |
| description | <i>Melissa officinalis</i> L. and <i>Origanum majorana</i> L., within Lamiaceae family, and <i>Calendula officinalis</i> L. and <i>Achillea millefolium</i> L., within the Asteraceae, have been considered a good source of bioactive ingredients with health benefits. In this study, the supercritical fluid extraction (SFE) using pure CO<sub>2</sub>, and the ultrasound assisted extraction (UAE) were proposed as green techniques to obtain plant-based extracts with potential antioxidant and anti-inflammatory activities. Higher values of total phenolic content and antioxidant activity were achieved in UAE ethanol:water (50:50, <i>v/v</i>) extracts. Meanwhile, UAE pure ethanol extracts showed greater anti-inflammatory activity. RP-HPLC-PAD-ESI-QTOF-MS/MS analysis showed a vast number of phenolic compounds in the extracts, including unreported ones. <i>O. majorana</i> ethanol:water extract presented the highest content of phenolics and antioxidant activity; among its composition, both rosmarinic acid and luteolin glucoside derivatives were abundant. The pure ethanol extract of <i>A. millefolium</i> resulted in an important content of caffeoylquinic acid derivatives, luteolin-7-<i>O</i>-glucoside and flavonoid aglycones, which could be related to the remarkable inhibition of TNF-α, IL-1<i>β</i> and IL-6 cytokines. Besides, borneol and camphor, found in the volatile fraction of <i>A. millefolium</i>, could contributed to this latter activity. Thus, this study points out that <i>O. majorana</i> and <i>A. millefolium</i> are considered a promising source of bioactive ingredients with potential use in health promotion. |
| first_indexed | 2024-03-10T07:40:47Z |
| format | Article |
| id | doaj.art-948b05194a884cdb918ae2c1f274480f |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T07:40:47Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-948b05194a884cdb918ae2c1f274480f2023-11-22T13:03:44ZengMDPI AGFoods2304-81582021-09-01109206710.3390/foods10092067Sustainable Extraction Techniques for Obtaining Antioxidant and Anti-Inflammatory Compounds from the Lamiaceae and Asteraceae SpeciesMarisol Villalva0Susana Santoyo1Lilia Salas-Pérez2María de las Nieves Siles-Sánchez3Mónica Rodríguez García-Risco4Tiziana Fornari5Guillermo Reglero6Laura Jaime7Institute of Food Science Research (CIAL), Universidad Autónoma de Madrid (CEI UAM+CSIC), 28049 Madrid, SpainInstitute of Food Science Research (CIAL), Universidad Autónoma de Madrid (CEI UAM+CSIC), 28049 Madrid, SpainFaculty of Accounting and Administration, Universidad Autónoma de Coahuila, Fco. Javier Mina 150, Luis Echeverría Álvarez Sector Norte, 27085 Torreón, Coahuila, MexicoInstitute of Food Science Research (CIAL), Universidad Autónoma de Madrid (CEI UAM+CSIC), 28049 Madrid, SpainInstitute of Food Science Research (CIAL), Universidad Autónoma de Madrid (CEI UAM+CSIC), 28049 Madrid, SpainInstitute of Food Science Research (CIAL), Universidad Autónoma de Madrid (CEI UAM+CSIC), 28049 Madrid, SpainInstitute of Food Science Research (CIAL), Universidad Autónoma de Madrid (CEI UAM+CSIC), 28049 Madrid, SpainInstitute of Food Science Research (CIAL), Universidad Autónoma de Madrid (CEI UAM+CSIC), 28049 Madrid, Spain<i>Melissa officinalis</i> L. and <i>Origanum majorana</i> L., within Lamiaceae family, and <i>Calendula officinalis</i> L. and <i>Achillea millefolium</i> L., within the Asteraceae, have been considered a good source of bioactive ingredients with health benefits. In this study, the supercritical fluid extraction (SFE) using pure CO<sub>2</sub>, and the ultrasound assisted extraction (UAE) were proposed as green techniques to obtain plant-based extracts with potential antioxidant and anti-inflammatory activities. Higher values of total phenolic content and antioxidant activity were achieved in UAE ethanol:water (50:50, <i>v/v</i>) extracts. Meanwhile, UAE pure ethanol extracts showed greater anti-inflammatory activity. RP-HPLC-PAD-ESI-QTOF-MS/MS analysis showed a vast number of phenolic compounds in the extracts, including unreported ones. <i>O. majorana</i> ethanol:water extract presented the highest content of phenolics and antioxidant activity; among its composition, both rosmarinic acid and luteolin glucoside derivatives were abundant. The pure ethanol extract of <i>A. millefolium</i> resulted in an important content of caffeoylquinic acid derivatives, luteolin-7-<i>O</i>-glucoside and flavonoid aglycones, which could be related to the remarkable inhibition of TNF-α, IL-1<i>β</i> and IL-6 cytokines. Besides, borneol and camphor, found in the volatile fraction of <i>A. millefolium</i>, could contributed to this latter activity. Thus, this study points out that <i>O. majorana</i> and <i>A. millefolium</i> are considered a promising source of bioactive ingredients with potential use in health promotion.https://www.mdpi.com/2304-8158/10/9/2067<i>Achillea millefolium</i><i>Origanum majorana</i>anti-inflammatory activityantioxidant activitysustainable extractionphenolic composition |
| spellingShingle | Marisol Villalva Susana Santoyo Lilia Salas-Pérez María de las Nieves Siles-Sánchez Mónica Rodríguez García-Risco Tiziana Fornari Guillermo Reglero Laura Jaime Sustainable Extraction Techniques for Obtaining Antioxidant and Anti-Inflammatory Compounds from the Lamiaceae and Asteraceae Species Foods <i>Achillea millefolium</i> <i>Origanum majorana</i> anti-inflammatory activity antioxidant activity sustainable extraction phenolic composition |
| title | Sustainable Extraction Techniques for Obtaining Antioxidant and Anti-Inflammatory Compounds from the Lamiaceae and Asteraceae Species |
| title_full | Sustainable Extraction Techniques for Obtaining Antioxidant and Anti-Inflammatory Compounds from the Lamiaceae and Asteraceae Species |
| title_fullStr | Sustainable Extraction Techniques for Obtaining Antioxidant and Anti-Inflammatory Compounds from the Lamiaceae and Asteraceae Species |
| title_full_unstemmed | Sustainable Extraction Techniques for Obtaining Antioxidant and Anti-Inflammatory Compounds from the Lamiaceae and Asteraceae Species |
| title_short | Sustainable Extraction Techniques for Obtaining Antioxidant and Anti-Inflammatory Compounds from the Lamiaceae and Asteraceae Species |
| title_sort | sustainable extraction techniques for obtaining antioxidant and anti inflammatory compounds from the lamiaceae and asteraceae species |
| topic | <i>Achillea millefolium</i> <i>Origanum majorana</i> anti-inflammatory activity antioxidant activity sustainable extraction phenolic composition |
| url | https://www.mdpi.com/2304-8158/10/9/2067 |
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