Kudzu isoflavone C‐glycosides: Analysis, biological activities, and metabolism
Abstract Radix Pueraria (the root of kudzu Pueraria lobota) is a popular traditional Chinese medicine used in dietary supplements in Western markets and has potential health benefits. Kudzu roots are rich in isoflavones C‐ and O‐glycosides, of which puerarin (daidzein 8‐C‐glucoside) is the most abun...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-09-01
|
| Series: | Food Frontiers |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/fft2.105 |
| _version_ | 1818662811525447680 |
|---|---|
| author | Jeevan K. Prasain Stephen Barnes J. Michael Wyss |
| author_facet | Jeevan K. Prasain Stephen Barnes J. Michael Wyss |
| author_sort | Jeevan K. Prasain |
| collection | DOAJ |
| description | Abstract Radix Pueraria (the root of kudzu Pueraria lobota) is a popular traditional Chinese medicine used in dietary supplements in Western markets and has potential health benefits. Kudzu roots are rich in isoflavones C‐ and O‐glycosides, of which puerarin (daidzein 8‐C‐glucoside) is the most abundant isoflavone. Puerarin is a unique isoflavone that it is resistant to intestinal hydrolysis and has a wide range of effects in preventing metabolic diseases. Our previous studies indicate that chronic exposure to a diet enriched in puerarin significantly reduces serum total cholesterol, arterial blood pressure, insulin resistance and hyperglycemia in ovariectomized, stroke‐prone spontaneously hypertensive rats (SP‐SHR), a model of metabolic syndrome. Further, our studies demonstrate that puerarin is absorbed as the intact glucoside and acutely improves glucose tolerance, indicating that it has potential for the prevention and treatment of diabetes. This paper reviews recent progress in the understanding of biological activities and metabolism and in the analysis of puerarin in kudzu root extracts or supplements. |
| first_indexed | 2024-12-17T05:06:53Z |
| format | Article |
| id | doaj.art-948bcd0ce707475f9dec64272b3e2ea7 |
| institution | Directory Open Access Journal |
| issn | 2643-8429 |
| language | English |
| last_indexed | 2024-12-17T05:06:53Z |
| publishDate | 2021-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Frontiers |
| spelling | doaj.art-948bcd0ce707475f9dec64272b3e2ea72022-12-21T22:02:24ZengWileyFood Frontiers2643-84292021-09-012338338910.1002/fft2.105Kudzu isoflavone C‐glycosides: Analysis, biological activities, and metabolismJeevan K. Prasain0Stephen Barnes1J. Michael Wyss2Departments of Pharmacology and Toxicology University of Alabama Birmingham Alabama United StatesDepartments of Pharmacology and Toxicology University of Alabama Birmingham Alabama United StatesDepartment of Cell Development and Integrative Biology University of Alabama Birmingham Alabama United StatesAbstract Radix Pueraria (the root of kudzu Pueraria lobota) is a popular traditional Chinese medicine used in dietary supplements in Western markets and has potential health benefits. Kudzu roots are rich in isoflavones C‐ and O‐glycosides, of which puerarin (daidzein 8‐C‐glucoside) is the most abundant isoflavone. Puerarin is a unique isoflavone that it is resistant to intestinal hydrolysis and has a wide range of effects in preventing metabolic diseases. Our previous studies indicate that chronic exposure to a diet enriched in puerarin significantly reduces serum total cholesterol, arterial blood pressure, insulin resistance and hyperglycemia in ovariectomized, stroke‐prone spontaneously hypertensive rats (SP‐SHR), a model of metabolic syndrome. Further, our studies demonstrate that puerarin is absorbed as the intact glucoside and acutely improves glucose tolerance, indicating that it has potential for the prevention and treatment of diabetes. This paper reviews recent progress in the understanding of biological activities and metabolism and in the analysis of puerarin in kudzu root extracts or supplements.https://doi.org/10.1002/fft2.105isoflavone C‐glycosidesKudzu rootsmetabolic diseasesmetabolismpuerarin |
| spellingShingle | Jeevan K. Prasain Stephen Barnes J. Michael Wyss Kudzu isoflavone C‐glycosides: Analysis, biological activities, and metabolism Food Frontiers isoflavone C‐glycosides Kudzu roots metabolic diseases metabolism puerarin |
| title | Kudzu isoflavone C‐glycosides: Analysis, biological activities, and metabolism |
| title_full | Kudzu isoflavone C‐glycosides: Analysis, biological activities, and metabolism |
| title_fullStr | Kudzu isoflavone C‐glycosides: Analysis, biological activities, and metabolism |
| title_full_unstemmed | Kudzu isoflavone C‐glycosides: Analysis, biological activities, and metabolism |
| title_short | Kudzu isoflavone C‐glycosides: Analysis, biological activities, and metabolism |
| title_sort | kudzu isoflavone c glycosides analysis biological activities and metabolism |
| topic | isoflavone C‐glycosides Kudzu roots metabolic diseases metabolism puerarin |
| url | https://doi.org/10.1002/fft2.105 |
| work_keys_str_mv | AT jeevankprasain kudzuisoflavonecglycosidesanalysisbiologicalactivitiesandmetabolism AT stephenbarnes kudzuisoflavonecglycosidesanalysisbiologicalactivitiesandmetabolism AT jmichaelwyss kudzuisoflavonecglycosidesanalysisbiologicalactivitiesandmetabolism |