FUT4siRNA augments the chemosensitivity of non-small cell lung cancer to cisplatin through activation of FOXO1-induced apoptosis

FUT4siRNA augments the chemosensitivity of non-small cell lung cancer to cisplatin through activation of FOXO1-induced apoptosis

Abstract Background Increased fucosylation is associated with the chemoresistance phenotype. Meanwhile, fucosyltransferase IV (FUT4) amounts are frequently elevated in lung cancer and may be related to increased chemoresistance. Methods In the present work, FUT4’s role in cisplatin-induced apoptosis...

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Bibliographic Details
Main Authors: Wei Gao, Jinxiao Liang, Yiru Ye, Jinlan Lu, Tongtong Lin, Na Wang, Jingyin Dong, Jianping Pan
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Cancer
Subjects:
FUT4
Chemosensitivity
Cisplatin
NSCLC
FOXO1
Online Access:http://link.springer.com/article/10.1186/s12885-020-07324-z

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