Virulence factors and antibiotic resistance properties of the Staphylococcus epidermidis strains isolated from hospital infections in Ahvaz, Iran
Abstract Background Resistant Staphylococcus epidermidis strains are considered to be one of the major causes of human clinical infections in hospitals. The present investigation was done to study the pattern of antibiotic resistance and the prevalence of virulence and antibiotic resistance genes am...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-12-01
|
| Series: | Tropical Medicine and Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41182-019-0180-7 |
| _version_ | 1818722739234537472 |
|---|---|
| author | Roya Chabi Hassan Momtaz |
| author_facet | Roya Chabi Hassan Momtaz |
| author_sort | Roya Chabi |
| collection | DOAJ |
| description | Abstract Background Resistant Staphylococcus epidermidis strains are considered to be one of the major causes of human clinical infections in hospitals. The present investigation was done to study the pattern of antibiotic resistance and the prevalence of virulence and antibiotic resistance genes amongst the S. epidermidis strains isolated from human hospital infections. Methods One hundred hospital infectious samples were collected and S. epidermidis strains were identified using culture and biochemical tests. Isolated strains were subjected to disk diffusion and PCR. Results Forty-six out of 100 hospital infectious samples (46%) were positive for S. epidermidis. S. epidermidis strains harbored the highest prevalence of resistance against penicillin (95.65%), tetracycline (91.30%), erythromycin (82.60%), cefazolin (78.26%), and trimethoprim-sulfamethoxazole (73.91%). All S. epidermidis strains had resistance against at least three different types of antibiotics, while the prevalence of resistance against more than seven types of antibiotics was 17.39%. AacA-D (69.56%), tetK (56.52%), mecA (45.65%), msrA (39.13%), and tetM (39.13%) were most commonly detected antibiotic resistance genes. The prevalence of vatC (4.34%), ermA (8.69%), vatA (8.69%), vatB (13.04%), ermC (13.04%), and linA (10.86%) were lower than other detected antibiotic resistance genes. ClfA (32.60%), agrIII (17.39%), and etB (13.04%) were the most commonly detected virulence factors. Conclusions The presence of virulent and multi-drug resistance S. epidermidis strains showed an important public health issue in hospitals. |
| first_indexed | 2024-12-17T20:59:25Z |
| format | Article |
| id | doaj.art-948fd06059404aaa8285d16a26d53eef |
| institution | Directory Open Access Journal |
| issn | 1349-4147 |
| language | English |
| last_indexed | 2024-12-17T20:59:25Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Tropical Medicine and Health |
| spelling | doaj.art-948fd06059404aaa8285d16a26d53eef2022-12-21T21:32:47ZengBMCTropical Medicine and Health1349-41472019-12-014711910.1186/s41182-019-0180-7Virulence factors and antibiotic resistance properties of the Staphylococcus epidermidis strains isolated from hospital infections in Ahvaz, IranRoya Chabi0Hassan Momtaz1Department of Microbiology, Shahrekord Branch, Islamic Azad UniversityDepartment of Microbiology, Shahrekord Branch, Islamic Azad UniversityAbstract Background Resistant Staphylococcus epidermidis strains are considered to be one of the major causes of human clinical infections in hospitals. The present investigation was done to study the pattern of antibiotic resistance and the prevalence of virulence and antibiotic resistance genes amongst the S. epidermidis strains isolated from human hospital infections. Methods One hundred hospital infectious samples were collected and S. epidermidis strains were identified using culture and biochemical tests. Isolated strains were subjected to disk diffusion and PCR. Results Forty-six out of 100 hospital infectious samples (46%) were positive for S. epidermidis. S. epidermidis strains harbored the highest prevalence of resistance against penicillin (95.65%), tetracycline (91.30%), erythromycin (82.60%), cefazolin (78.26%), and trimethoprim-sulfamethoxazole (73.91%). All S. epidermidis strains had resistance against at least three different types of antibiotics, while the prevalence of resistance against more than seven types of antibiotics was 17.39%. AacA-D (69.56%), tetK (56.52%), mecA (45.65%), msrA (39.13%), and tetM (39.13%) were most commonly detected antibiotic resistance genes. The prevalence of vatC (4.34%), ermA (8.69%), vatA (8.69%), vatB (13.04%), ermC (13.04%), and linA (10.86%) were lower than other detected antibiotic resistance genes. ClfA (32.60%), agrIII (17.39%), and etB (13.04%) were the most commonly detected virulence factors. Conclusions The presence of virulent and multi-drug resistance S. epidermidis strains showed an important public health issue in hospitals.https://doi.org/10.1186/s41182-019-0180-7Staphylococcus epidermidisAntibiotic resistanceAntibiotic resistance genesHospital infectionsIran |
| spellingShingle | Roya Chabi Hassan Momtaz Virulence factors and antibiotic resistance properties of the Staphylococcus epidermidis strains isolated from hospital infections in Ahvaz, Iran Tropical Medicine and Health Staphylococcus epidermidis Antibiotic resistance Antibiotic resistance genes Hospital infections Iran |
| title | Virulence factors and antibiotic resistance properties of the Staphylococcus epidermidis strains isolated from hospital infections in Ahvaz, Iran |
| title_full | Virulence factors and antibiotic resistance properties of the Staphylococcus epidermidis strains isolated from hospital infections in Ahvaz, Iran |
| title_fullStr | Virulence factors and antibiotic resistance properties of the Staphylococcus epidermidis strains isolated from hospital infections in Ahvaz, Iran |
| title_full_unstemmed | Virulence factors and antibiotic resistance properties of the Staphylococcus epidermidis strains isolated from hospital infections in Ahvaz, Iran |
| title_short | Virulence factors and antibiotic resistance properties of the Staphylococcus epidermidis strains isolated from hospital infections in Ahvaz, Iran |
| title_sort | virulence factors and antibiotic resistance properties of the staphylococcus epidermidis strains isolated from hospital infections in ahvaz iran |
| topic | Staphylococcus epidermidis Antibiotic resistance Antibiotic resistance genes Hospital infections Iran |
| url | https://doi.org/10.1186/s41182-019-0180-7 |
| work_keys_str_mv | AT royachabi virulencefactorsandantibioticresistancepropertiesofthestaphylococcusepidermidisstrainsisolatedfromhospitalinfectionsinahvaziran AT hassanmomtaz virulencefactorsandantibioticresistancepropertiesofthestaphylococcusepidermidisstrainsisolatedfromhospitalinfectionsinahvaziran |