Comparison of pathological characteristics between self-detected and screen-detected invasive breast cancers in Chinese women: a retrospective study
Background In China, there is insufficient evidence to support that screening programs can detect breast cancer earlier and improve outcomes compared with patient self-reporting. Therefore, we compared the pathological characteristics at diagnosis between self-detected and screen-detected cases of i...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PeerJ Inc.
2018-04-01
|
| Series: | PeerJ |
| Subjects: | |
| Online Access: | https://peerj.com/articles/4567.pdf |
| _version_ | 1797424264286044160 |
|---|---|
| author | Qi Zhang Lanjun Ding Xuan Liang Yuan Wang Jiao Jiao Wenli Lu Xiaojing Guo |
| author_facet | Qi Zhang Lanjun Ding Xuan Liang Yuan Wang Jiao Jiao Wenli Lu Xiaojing Guo |
| author_sort | Qi Zhang |
| collection | DOAJ |
| description | Background In China, there is insufficient evidence to support that screening programs can detect breast cancer earlier and improve outcomes compared with patient self-reporting. Therefore, we compared the pathological characteristics at diagnosis between self-detected and screen-detected cases of invasive breast cancer at our institution and determined whether these characteristics were different after the program’s introduction (vs. prior to). Methods Three databases were selected (breast cancer diagnosed in 1995–2000, 2010, and 2015), which provided a total of 3,014 female patients with invasive breast cancer. The cases were divided into self-detected and screen-detected groups. The pathological characteristics were compared between the two groups and multiple imputation and complete randomized imputation were used to deal with missing data. Results Compared with patient self-reporting, screening was associated with the following factors: a higher percentage of stage T1 tumors (75.0% vs 17.1%, P = 0.109 in 1995–2000; 66.7% vs 40.4%, P < 0.001 in 2010; 67.8% vs 35.7%, P < 0.001 in 2015); a higher percentage of tumors with stage N0 lymph node status (67.3% vs. 48.4%, P = 0.007 in 2010); and a higher percentage of histologic grade I tumors (22.9% vs 13.9%, P = 0.017 in 2010). Conclusion Screen-detected breast cancer was associated with a greater number of favorable pathological characteristics. However, although screening had a beneficial role in early detection in China, we found fewer patients were detected by screening in this study compared with those in Western and Asian developed countries. |
| first_indexed | 2024-03-09T07:59:47Z |
| format | Article |
| id | doaj.art-94929ad0e69d4e41be40d7e54aabc1b0 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T07:59:47Z |
| publishDate | 2018-04-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-94929ad0e69d4e41be40d7e54aabc1b02023-12-03T00:48:57ZengPeerJ Inc.PeerJ2167-83592018-04-016e456710.7717/peerj.4567Comparison of pathological characteristics between self-detected and screen-detected invasive breast cancers in Chinese women: a retrospective studyQi Zhang0Lanjun Ding1Xuan Liang2Yuan Wang3Jiao Jiao4Wenli Lu5Xiaojing Guo6Department of Breast Pathology and Lab, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaDepartment of Epidemiology and Health Statistics, Tianjin Medical University, Tianjin, ChinaDepartment of Epidemiology and Health Statistics, Tianjin Medical University, Tianjin, ChinaDepartment of Epidemiology and Health Statistics, Tianjin Medical University, Tianjin, ChinaDepartment of Breast Pathology and Lab, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaDepartment of Epidemiology and Health Statistics, Tianjin Medical University, Tianjin, ChinaDepartment of Breast Pathology and Lab, Tianjin Medical University Cancer Institute and Hospital, Tianjin, ChinaBackground In China, there is insufficient evidence to support that screening programs can detect breast cancer earlier and improve outcomes compared with patient self-reporting. Therefore, we compared the pathological characteristics at diagnosis between self-detected and screen-detected cases of invasive breast cancer at our institution and determined whether these characteristics were different after the program’s introduction (vs. prior to). Methods Three databases were selected (breast cancer diagnosed in 1995–2000, 2010, and 2015), which provided a total of 3,014 female patients with invasive breast cancer. The cases were divided into self-detected and screen-detected groups. The pathological characteristics were compared between the two groups and multiple imputation and complete randomized imputation were used to deal with missing data. Results Compared with patient self-reporting, screening was associated with the following factors: a higher percentage of stage T1 tumors (75.0% vs 17.1%, P = 0.109 in 1995–2000; 66.7% vs 40.4%, P < 0.001 in 2010; 67.8% vs 35.7%, P < 0.001 in 2015); a higher percentage of tumors with stage N0 lymph node status (67.3% vs. 48.4%, P = 0.007 in 2010); and a higher percentage of histologic grade I tumors (22.9% vs 13.9%, P = 0.017 in 2010). Conclusion Screen-detected breast cancer was associated with a greater number of favorable pathological characteristics. However, although screening had a beneficial role in early detection in China, we found fewer patients were detected by screening in this study compared with those in Western and Asian developed countries.https://peerj.com/articles/4567.pdfBreast cancerScreen-detectedSelf-detectedChinesePathological characteristics |
| spellingShingle | Qi Zhang Lanjun Ding Xuan Liang Yuan Wang Jiao Jiao Wenli Lu Xiaojing Guo Comparison of pathological characteristics between self-detected and screen-detected invasive breast cancers in Chinese women: a retrospective study PeerJ Breast cancer Screen-detected Self-detected Chinese Pathological characteristics |
| title | Comparison of pathological characteristics between self-detected and screen-detected invasive breast cancers in Chinese women: a retrospective study |
| title_full | Comparison of pathological characteristics between self-detected and screen-detected invasive breast cancers in Chinese women: a retrospective study |
| title_fullStr | Comparison of pathological characteristics between self-detected and screen-detected invasive breast cancers in Chinese women: a retrospective study |
| title_full_unstemmed | Comparison of pathological characteristics between self-detected and screen-detected invasive breast cancers in Chinese women: a retrospective study |
| title_short | Comparison of pathological characteristics between self-detected and screen-detected invasive breast cancers in Chinese women: a retrospective study |
| title_sort | comparison of pathological characteristics between self detected and screen detected invasive breast cancers in chinese women a retrospective study |
| topic | Breast cancer Screen-detected Self-detected Chinese Pathological characteristics |
| url | https://peerj.com/articles/4567.pdf |
| work_keys_str_mv | AT qizhang comparisonofpathologicalcharacteristicsbetweenselfdetectedandscreendetectedinvasivebreastcancersinchinesewomenaretrospectivestudy AT lanjunding comparisonofpathologicalcharacteristicsbetweenselfdetectedandscreendetectedinvasivebreastcancersinchinesewomenaretrospectivestudy AT xuanliang comparisonofpathologicalcharacteristicsbetweenselfdetectedandscreendetectedinvasivebreastcancersinchinesewomenaretrospectivestudy AT yuanwang comparisonofpathologicalcharacteristicsbetweenselfdetectedandscreendetectedinvasivebreastcancersinchinesewomenaretrospectivestudy AT jiaojiao comparisonofpathologicalcharacteristicsbetweenselfdetectedandscreendetectedinvasivebreastcancersinchinesewomenaretrospectivestudy AT wenlilu comparisonofpathologicalcharacteristicsbetweenselfdetectedandscreendetectedinvasivebreastcancersinchinesewomenaretrospectivestudy AT xiaojingguo comparisonofpathologicalcharacteristicsbetweenselfdetectedandscreendetectedinvasivebreastcancersinchinesewomenaretrospectivestudy |